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Author Topic: Research News: Elvitegravir and TMC278 show promise...  (Read 1718 times)

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Offline Ihavehope

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Research News: Elvitegravir and TMC278 show promise...
« on: March 01, 2007, 05:47:49 PM »

TMC278: Anton Pozniak of London's Chelsea and Westminster Hospital on Wednesday at the conference reported on a study funded by J & J that compared three different doses of TMC278 with a regimen containing Bristol-Myers Squibb's Sustiva, Reuters reports (Reuters, 2/28). The drug combinations were administered during 48 weeks to 368 HIV-positive people who had not previously received antiretrovirals, the Times reports (Los Angeles Times, 3/1). The Phase II study found that 77% to 81% of participants who received TMC278 experienced a decrease in viral loads to undetectable levels, compared with 80% of participants on a standard dose of Sustiva. According to Pozniak, serious adverse events occurred in about 10% of both TMC278 and Sustiva participants. Nervous system disorders affected 33% of those who received TMC278, compared with 53% of those who received Sustiva, Pozniak said. J & J will test a 75-mg dose of the drug in a Phase III trial, according to Pozniak (Reuters, 2/28).

Elvitegravir: Andrew Zolopa of Stanford University reported on a study that involved 278 HIV-positive people who already were receiving standard antiretrovirals, the Times reports. For the study, one group received a 50-mg dose of elvitegravir, a second group received a 125-mg dose and a third group received a protease inhibitor. The study found the group that received a 50-mg dose showed some signs of benefiting from the drug. The participants who received the 125-mg dose had a 98% reduction in viral loads after 24 weeks, compared with a 94% reduction in viral loads recorded in the third group, the study found. According to Zolopa, although elvitegravir appeared effective, viral loads tended to rebound slightly after a few weeks. Testing will continue on the drug, which likely will not be available before 2009, Gilead officials said.

Infected: April 2005
12/6/06 - Diagnosed HIV positive
12/19/06 - CD4 = 240  22% VL = 26,300
1/4/07 - CD4 = 200 16% VL = ?
2/9/07 = Started Kaletra/Truvada
3/13/07 = CD4 = 386 22% VL ?


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