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Author Topic: Micronutrient Suppl Incrses CD4 Count in HIV-Infected Individls on HAART  (Read 2084 times)

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Offline bimazek

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Micronutrient Supplementation Increases CD4 Count in HIV-Infected Individuals on Highly Active - group of 7
JD Kaiser, AM Campa, JP Ondercin, GS Leoung, RF - JAIDS Journal of Acquired Immune Deficiency Syndromes, 2006 - jaids.org
... al47 reported in an uncontrolled clinical trial that antioxidant supplementation
with vitamins C and E and N-acetyl-cysteine provided to HIV-infected patients ... \

Micronutrient Supplementation Increases CD4 Count in HIV-Infected Individuals on Highly Active Antiretroviral Therapy: A Prospective, Double-Blinded, Placebo-Controlled Trial.

Rapid Communication
JAIDS Journal of Acquired Immune Deficiency Syndromes. 42(5):523-528, August 15, 2006.
Kaiser, Jon D. MD *; Campa, Adriana M. PhD +; Ondercin, Joseph P. PA-C ++; Leoung, Gifford S. MD ; Pless, Richard F. PhD [//]; Baum, Marianna K. PhD dagger;

Objective: To examine the immunologic, metabolic, and clinical effects of broad spectrum micronutrient supplementation in HIV-infected patients taking highly active antiretroviral therapy (HAART).

Design: A prospective, randomized, double-blinded, placebo-controlled trial.

Methods: Forty HIV-infected patients taking a stavudine and/or didanosine-based HAART regimen were prospectively randomized to receive micronutrients or placebo twice daily for 12 weeks. Data were collected at 4-week intervals including immunologic, metabolic, and clinical measurements. The study examined the effect of micronutrient supplementation on immunologic parameters as the primary end point. The secondary end points were metabolic and clinical effects and distal symmetrical polyneuropathy.

Results: The mean absolute CD4 count increased by an average of 65 cells in the micronutrient group versus a 6-cell decline in the placebo group at 12 weeks (P = 0.029). The absolute CD4 count increased by an average of 24% in the micronutrient group versus a 0% change in the placebo group (P = 0.01). The mean HIV-1 RNA decreased in the micronutrient supplementation group, although not significantly. Neuropathy scores improved in the micronutrient group by 42% compared with a 33% improvement in the placebo arm. This difference did not reach statistical significance. Fasting serum glucose, insulin, and lipids were not adversely affected in the patients taking the micronutrients.

Conclusions: Micronutrient supplementation can significantly improve CD4 cell count reconstitution in HIV-infected patients taking HAART. The micronutrient supplement tested was well tolerated and may hold promise as an adjuvant therapy in the treatment of HIV. Further investigation is warranted.


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