Welcome, Guest. Please login or register.
November 24, 2017, 03:07:50 AM

Login with username, password and session length

  • Total Members: 31872
  • Latest: Bwolv
  • Total Posts: 722738
  • Total Topics: 58739
  • Online Today: 154
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 3
Guests: 115
Total: 118


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: emerin - a potential new class of meds being studied (stops wasting?)  (Read 2586 times)

0 Members and 1 Guest are viewing this topic.

Offline bimazek

  • Member
  • Posts: 781

isnt this interesting the exact protein that hiv needs and uses and the gene that produce it,  the protein  called emerin, if blocked or knocked out stops hiv entering nucleus,  we know that hiv can damage muscle tissue...
this  exact protein that hiv needs and uses and the gene that produce it,  the protein  called emerin... is key in Musclular distrophy also... so hiv research may help solve this and this may be a way to stop wasting

 May 08, 2006
Protein Permits HIV Invasion
By David Biello
   Science Image: HIV, human immunodeficiency virus
The human immunodeficiency virus (HIV) that causes AIDS prospers by hijacking our immune system cells and forcing them to manufacture more copies of itself rather than tend to their infection-fighting duties. But in order to hijack these T cells or macrophages HIV must first penetrate their innermost walls. New research shows that HIV requires a particular protein in the envelope surrounding a macrophage's nucleus in order to slip in and reconfigure the cell's DNA.

Mario Stevenson and Jean-Marc Jacque of the University of Massachusetts first studied macrophages--literally big eaters, which consume infectious agents and other detritus in the body--because they rarely divide. Therefore, the walls of this cell could be studied without having to inhibit it from its natural processes. The scientists knocked out a protein--emerin--and unleashed HIV (seen in a schematic cross-section above) on the cells to see what would happen.In the absence of emerin, HIV found it difficult to enter its prospective host's nucleus and nearly impossible to effectively insert itself into the nuclear DNA, or chromatin.

Without such insertion, the HIV failed to replicate and thus failed to do much of its damaging work. "Our study provides evidence that [HIV DNA], on entering the nucleus, must interact with emerin to contact chromatin," the researchers write in a paper published online yesterday by Nature.
Study of pharmaceuticals or other molecules that might inhibit the ability of HIV to interact with emerin might provide a new pathway to fighting the scourge, the scientists argue. They also note that Emery-Dreifuss muscular dystrophy results from mutations in the gene that codes for emerin. Sufferers of that disease might reveal compelling evidence of HIV-resistance.

Offline Ihavehope

  • Member
  • Posts: 1,366
  • Yes, I'm a cry baby, AND WHAT?
Re: emerin - a potential new class of meds being studied (stops wasting?)
« Reply #1 on: February 08, 2007, 07:53:50 PM »
I hope it is true and it works for us, especially those who are suffering severe Lipo wasting.
Infected: April 2005
12/6/06 - Diagnosed HIV positive
12/19/06 - CD4 = 240  22% VL = 26,300
1/4/07 - CD4 = 200 16% VL = ?
2/9/07 = Started Kaletra/Truvada
3/13/07 = CD4 = 386 22% VL ?


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.