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Author Topic: Is this a case of delayed seroconversion?  (Read 821 times)

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Offline kserani

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Is this a case of delayed seroconversion?
« on: January 18, 2021, 04:46:15 pm »
I believe I had a moderate-high risk in June 2020, where I met a couple from Grindr, who lied about their HIV status (and leads me to believe they also probably had STDs)
We had a threesome where I was wanking one guy off while his boyfriend was grinding against my penis (heavy pre-cum spilling throughout). The guy grinding against my penis ejaculated onto my penis and was rubbing the cum on my head and foreskin, and the other guy ejaculated on my face and a good amount got into my hair, eye, and nose

Out of fear, I didn't get tested and then in early December I had a needlestick injury (I'm a volunteer at a health centre) but 5 days later that guy tested negative for HIV/Hep C. Because of how busy the A&E was, the doctor didn't test me for HIV before giving me a one week prescription for PEP.

I was only on PEP for 5 days (until I found out that guy’s results) and have been off it for 34 days now.

Yesterday, (200 days after the first exposure), I took a finger-prick 2nd generation Antibody-only test (BIOsure self test), and it read negative.

Would the 5-day PEP course I stopped 34 days ago, suppress the antibodies/seroconversion from my June exposure and give me a false negative, keeping in mind The BIOsure 2nd generation HIV test only tests for antibodies?
« Last Edit: January 18, 2021, 04:58:47 pm by kserani »

Offline Jim Allen

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Re: Is this a case of delayed seroconversion?
« Reply #1 on: January 18, 2021, 06:50:10 pm »
The June encounter you posted here was no HIV concern and no specific testing needed.

As for the more recent exposure, odds of acquiring HIV are tiny to start with but repeat the test at 3 months post finishing PEP to know your HIV status.

Here's what you need to know to avoid HIV infection:
Use condoms for anal or vaginal intercourse, correctly and consistently, every time, no exceptions. Consider talking to your healthcare provider about PrEP as an additional layer of HIV protection going forward.

Keep in mind that some sexual practices which may be described as ‘safe’ in terms of HIV transmission might still pose a risk for transmission of other STI's, so please do get fully tested regularly and at least yearly for all STI's including but not limited to HIV and test more frequently if unprotected intercourse occurs

Also, note that it is possible to have an STI and show no signs or symptoms and the only way of knowing is by testing.

Kind regards

Jim

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« Last Edit: January 18, 2021, 06:53:40 pm by Jim Allen »
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Offline kserani

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Re: Is this a case of delayed seroconversion?
« Reply #2 on: January 18, 2021, 07:31:38 pm »
With regards to the June encounter, they both have detectable levels (are not UD) and yet with the cum going directly in my eye and urethra, how does that not pose an HIV and STD risk given that they’re both mucosal membranes? (I’m having some burning/pain in the penis bladder area rn, sporadic joint/muscle pain, random ulcer in mouth, etc)

The recent exposure (December) has been cleared up. The patient was tested with blood work, and was negative for all blood borne viruses. In the time it took for his bloods to come back, I was on PEP, but stopped PEP after 5 days when his blood work came back negative.

My question is:
Would the June exposure (if I have contracted HIV from those two guys) create enough antibodies 6 months down the line that would be detected by the BIOsure 2nd gen finger prick test, even though I stopped PEP 34 days ago. Like, would the 5 days of PEP interfere with my negative result from yesterday?

Offline Jim Allen

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Re: Is this a case of delayed seroconversion?
« Reply #3 on: January 18, 2021, 07:51:40 pm »
Quote
The recent exposure (December) has been cleared up. The patient was tested with blood work, and was negative for all blood borne viruses. In the time it took for his bloods to come back, I was on PEP, but stopped PEP after 5 days when his blood work came back negative.

The patient tested. All that means is they did not have HIV 3 months ago, not much good to you. As said odds of acquiring HIV are tiny to start with but repeat the test at 3 months post finishing PEP to know your HIV status.

Quote
With regards to the June encounter, they both have detectable levels (are not UD) and yet with the cum going directly in my eye and urethra, how does that not pose an HIV and STD risk given that they’re both mucosal membranes? (I’m having some burning/pain in the penis bladder area rn, sporadic joint/muscle pain, random ulcer in mouth, etc)

Not even going to ask how you know factually they have detectable levels of HIV.

Anyhow for risk assessments, we presume the person you had contact with is living with HIV and without treatment. HIV is fragile and sexually only HIV is transmitted within the confines of the human body, without exposure to the environment. As for other easier to acquire STI's absolutely, there were risks, nothing worth testing for outside of standard yearly routine though.

Quote
Would the June exposure (if I have contracted HIV from those two guys) create enough antibodies 6 months down the line that would be detected by the BIOsure 2nd gen finger prick test, even though I stopped PEP 34 days ago. Like, would the 5 days of PEP interfere with my negative result from yesterday?

Your question is rather misinformed. You had no exposure in June, but if you had acquired HIV 6 months ago then you would test reactive and no amount of PEP 6 months down the line would ever change that.

« Last Edit: January 18, 2021, 07:56:20 pm by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline kserani

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Re: Is this a case of delayed seroconversion?
« Reply #4 on: January 18, 2021, 08:25:31 pm »
The patient had his bloods taken that day and sent to a lab. In the meantime, A&E only gave me 1 week of PEP (and I was never prescribed more), which I stopped taking 5 days into it, when his bloods came back negative. Doesn’t the lab blood test mean he’s clear as of 2-4 weeks earlier before exposure?

As for those guys, I found them on the app again, and after a conversation, found out they’re not negative as they had been posing earlier, and after revealing who I was, they said “our status didn’t matter because we weren’t doing anything extreme anyway” and then blocked me, and I haven’t been able to find them since, so I’ve been scared ever since.

I had read that PEP can delay seroconversion, so are you saying that if I was positive from the June exposure, even though I was on PEP, and stopped it 34 days ago, that would have absolutely no effect on the 2nd Gen BIOsure HIV test’s ability to detect antibodies in my blood? Is it that accurate still? Can I conclusively say I am 100% negative and don’t have HIV from that exposure?

(I’m taking my bloods tomorrow, for the lab to test, and that will come back negative too if the Dec needlestick truly was negative right?)

Thank you so much again, Jim

Offline Jim Allen

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Re: Is this a case of delayed seroconversion?
« Reply #5 on: January 18, 2021, 08:49:38 pm »
Quote
As for those guys, I found them on the app again, and after a conversation, found out they’re not negative as they had been posing earlier, and after revealing who I was, they said “our status didn’t matter because we weren’t doing anything extreme anyway” and then blocked me, and I haven’t been able to find them since, so I’ve been scared ever since.

I don't understand why you had been trying to find them. I also don't see how this means anything or how you concluded they have a detectable viral load.

Anyhow, sorry to hear you have been scared but regardless of their HIV status what you posted about the encounter wasn't an HIV concern. Try to put this behind you and move on with your life.

Quote
The patient had his bloods taken that day and sent to a lab. In the meantime, A&E only gave me 1 week of PEP (and I was never prescribed more), which I stopped taking 5 days into it, when his bloods came back negative. Doesn’t the lab blood test mean he’s clear as of 2-4 weeks earlier before exposure?

I've already answered this.

Quote
I had read that PEP can delay seroconversion, so are you saying that if I was positive from the June exposure, even though I was on PEP, and stopped it 34 days ago, that would have absolutely no effect on the 2nd Gen BIOsure HIV test’s ability to detect antibodies in my blood? Is it that accurate still? Can I conclusively say I am 100% negative and don’t have HIV from that exposure?

Firstly, PEP if taken within 72 hours post potential exposure is highly effective in preventing HIV from taking hold, however, in cases that it does not prevent the infection there is a small chance it could slightly delay seroconversion from that exposure. However, it does not and can't suppress antibodies produced in response to a prior established HIV infection like you are fearing.

End of the day, you had no exposure 6 months ago from what you posted here, but even if you had acquired HIV 6 months ago from some another incident, then your test result would be reactive, your test result was non-reactive and, you did not acquire HIV 6 months ago.

Quote
(I’m taking my bloods tomorrow, for the lab to test, and that will come back negative too if the Dec needlestick truly was negative right?)

I presume the blood tests include an HIV test.

If you test at 6 weeks after finishing PEP with a blood-drawn HIV antibodies test, a negative result at that time will rarely ever change and retesting is generally not needed, but, if you wish you can retest for a definite result at 3 months.

If you are using rapid tests wait for the 3-month mark to test.

Jim
« Last Edit: January 18, 2021, 08:57:16 pm by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

 


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