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Author Topic: Biktarvy, Juluca or Dovato  (Read 942 times)

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Offline pozzitive

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Biktarvy, Juluca or Dovato
« on: September 21, 2020, 08:10:20 pm »
My doctor wants to change my meds and is considering these tree: Biktarvy, Juluca or Dovato. I am currently under Genvoya and all is good but he is telling me that we should switch to something newer. Are these new drugs less toxic or is it all the same thing?

Thanks.
POZ since 2000 \ Truvada and Viramune

"I can be changed by what happens to me. but I refuse to be reduced by it.

Offline Matths

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Re: Biktarvy, Juluca or Dovato
« Reply #1 on: September 21, 2020, 10:17:22 pm »
Hi, there is lots of literature on all 3 possible options. However, why would you even consider switching medicines if the current medication works for you and you have no side effects? Never change a winning team. Or are there reasons to change treatment?

If you switch, here are some thoughts: all 3 medications were shown to work well for people who have achieved UD status and switch treatment. Juluca and Dovato are 2-drug treatments. Both are built around dolutegravir which has a high barrier to resistance and Juluca you must take with food, Dovato you can take with or without food. I personally take Dovato. Im happy with it, Im UD with VL<20. I decided to switch to a 2-drug combo because I preferred a treatment with high barrier to resistance, easy to take (no food requirement), no side effects and most importantly over time I avoid taking a 3rd drug. Plus, my insurance plus viiv card provide me with $0 co-pay which helps. Bictarvy is a 3-drug combo with a next generation integrase inhibitor compared to whats the backbone in your current treatment. I have no
personal experience but I assume many here have. I have 100% compliance and it was discussed that for people who miss a dose here and then, a 3-drug combo may be preferable but missing a dose is never a good idea.

Offline wardp

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Re: Biktarvy, Juluca or Dovato
« Reply #2 on: September 22, 2020, 10:12:51 am »
If it ain't broken why try and fix it. Unless you are having bad side effects?
Diagnosed 20,July 2017. Cd4 289, 21% vld .3,462 Started atripla 4 Aug 2017 5oct 2017 cd4 384 21%, vl ud less than 20. Switch to complera 4 Nov 2017 switched to stribild 15 the Nov. Switched to truvada efavirence 200mgx2 14 Dec 2017, 2 Feb 2018, us cd4  466, 25%  CD 8 ,595, 32%..1 may 2018
switched  to instgra truvada.7th june switched to truvada  nevirapine stavudine. .21 june switched to truvada nevirapine. X 2 a day...9 aug 2018 ud. 2n Nov 2018 CD 4. 455..22.70% 13th Nov switched  to lamivir and nevirapine  due to kidney issues...jan 10,2019 UD..may 13 2019 ud  cd4 482 28% 14th nov 2019 ud. Cd4 414 .27% cd8 444 29%,may 16 2020,ud ,cd4 741"19.62.

Offline pozzitive

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Re: Biktarvy, Juluca or Dovato
« Reply #3 on: September 22, 2020, 01:53:23 pm »
Thank you, my doctor syas that these drugs are newer and better but I need to hear from him why.
POZ since 2000 \ Truvada and Viramune

"I can be changed by what happens to me. but I refuse to be reduced by it.

Offline Texland

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Re: Biktarvy, Juluca or Dovato
« Reply #4 on: September 25, 2020, 02:05:10 pm »
I started Biktarvy when it was in clinical trials. After about two months, I gained 25 pounds, fast. The doctor insisted it wasn't a side effect of the medication. Fast forward a few years and the doctor said they recently discovered that Biktarvy does cause weight gain in some patients. He switched me to Dovato.

I also had racing/pounding heart beat often when I was on Biktarvy. In the eight months since I switched to Dovato it's only happened twice. Again the doctor says that isn't a side effect of Biktarvy. Other than that, I've not noticed anything different since changing medications.

Offline randym431

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Re: Biktarvy, Juluca or Dovato
« Reply #5 on: September 27, 2020, 05:28:32 am »
I was switched to Biktarvy about 2 years ago. Newer meds according to my doc as the reason. My labs were good on Atripla but better on Biktarvy. Kidney function better, and undetectable was really undetectable like less than considered undetectable. But oh boy did I gain the weight. Gained like 30#'s. Biktarvy says 2% might experience gain weight but I knew that was a lie or them fudging the figures. From what I experienced and from others I know taking Biktarvy it's more like 80% will experience weight gain. A lot of weight gain. And this is the type of weight gain experienced back in the early days of meds where the weight gain is all in the gut. A bloated stomach appearance. I have also recently noticed a gain around my neck area and shoulder area, another common weight issue with the old class of hiv meds. I have an appointment this week to see about changing to something else. I predict that the makers of Biktarvy will eventually get in trouble for misleading the pubic on the side effect of weight gain. 
Diag Sept 2005 VL 1mill, CD4 85, 3%, weight 143# (195# normal)
Sept 2020, undetectable, weight 228#.

Offline Jim Allen

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Re: Biktarvy, Juluca or Dovato
« Reply #6 on: September 27, 2020, 05:49:57 am »
My doctor wants to change my meds and is considering these tree: Biktarvy, Juluca or Dovato. I am currently under Genvoya and all is good but he is telling me that we should switch to something newer. Are these new drugs less toxic or is it all the same thing?

Thanks.

Hi OP.

They aren't toxic to start with, anyhow, look it's up to you if you wish to switch or not.

However, I would not change meds unless there was a good reason. Both combinations are reasonably new, both like any drugs can cause potential side-effects for some people, plenty take them without any issues.

If your current regime is working and not causing any problems, I would have another chat with the doctor asking them to justify the switch beyond just the "it's newer" line.

Best, Jim

https://www.poz.com/drug/genvoya
https://www.poz.com/drug/biktarvy
« Last Edit: September 27, 2020, 05:53:10 am by Jim Allen »
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Offline harleymc

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Re: Biktarvy, Juluca or Dovato
« Reply #7 on: September 30, 2020, 04:24:03 am »
Initially I gained weight on Biktarvy, but I've been watching what I eat and keeping somewhat active, but not crazy, the weight is coming off again.

 


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