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Author Topic: Inflammation - what does it mean?  (Read 171 times)

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Offline Loa111

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Inflammation - what does it mean?
« on: July 28, 2020, 07:08:22 am »
I've read on this forum in different threads that hiv even when on treatment causes ones body to be in a chronic state of inflammation.

I'm wondering what does this mean exactly in layman's terms?

E.g. does it mean your organs are suffer inflammation, or your muscles, or what?
I cannot get the idea out of my head that it is the same type of inflammation one gets if you twisted your ankle and it swelled up!  :o

I've also read the inflammation is an issue that so far has no fix?

Offline Jim Allen

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Re: Inflammation - what does it mean?
« Reply #1 on: July 28, 2020, 08:33:52 am »

Your on the right track in regards to the swollen ankle and the swelling being a immune response.

The how/why, in short, HIV causes an immune response, your HIV is suppressed but not gone and the low levels of the virus found in places in the body can cause the immune system to constantly be engaged when it's not really needed.

It's linked to accelerated ageing under the HIV population, so a factor as to why we as a group tend to experience some health issues earlier then our HIV negative counterparts.

I added some easy to digest info below.


What Is Chronic Inflammation?

When you get a cut or infection, your immune system jump-starts a cascading process that sends to the site a diverse army of cells that promote healing and infection control and give rise to inflammation. Included in this complex, interconnected battalion are CD4 and CD8 cells (known as “helper” and “killer” T-cells), antibodies, clotting factors and pro-inflammatory cytokines, among many others.

Normally, certain cells will turn off this healthy inflammatory process when the healing or infection-fighting process is complete. But sometimes, inflammation persists over the long term and can become counterproductive, causing damage to healthy cells and tissues. In HIV-negative people, chronic inflammation is tied to a host of diseases, including cardiovascular, autoimmune, liver and kidney diseases and cancer.

HIV itself appears to give rise to chronic inflammation. The virus also leads to dysregulation of the immune system, which can further fuel inflammation. Many scientists believe that HIV-related chronic inflammation contributes to HIV-positive individuals’ increased risk of cardiovascular disease, neurocognitive disease, osteoporosis (bone loss), liver disease, kidney disease, frailty and some non-AIDS-defining cancers. These are all conditions associated with getting older. People with HIV tend to get them at younger ages than their HIV-negative counterparts.

While HIV treatment does help fight the immune dysfunction and chronic inflammation caused by the virus, ARVs don’t necessarily wipe out these effects. For one thing, having an undetectable viral load doesn’t mean the virus is totally silent. Low-level viral replication may still persist—and at a high enough level to prompt a constant state of alert from the immune system, a chronic inflammatory state. Consequently, over-activated immune cells may be driven to a state of exhaustion, similar to what is seen in older people. HIV may also disrupt the cells that turn inflammation on or off, possibly compromising the body’s ability to properly regulate inflammation.

People with HIV tend to have higher rates of other viral infections, such as hepatitis B or C viruses (HBV, HCV) and cytomegalovirus (CMV, which is in the herpes family), which may also contribute to chronic inflammation and immune activation

« Last Edit: July 28, 2020, 09:36:00 am by Jim Allen »
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Offline Loa111

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Re: Inflammation - what does it mean?
« Reply #2 on: July 28, 2020, 11:29:17 am »
Good info there Jim thank you.

Not so far in my journey as my ID Doc mentioned inflammation to me, however he did mention it is important to do cardio for the heart & weights for the bone strength.

Hopefully researchers will come up with a solution to ease the inflammation factor someday.


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