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Author Topic: Choices outside of NNRTI and NRTI  (Read 235 times)

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Offline LauderdaleDennis

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Choices outside of NNRTI and NRTI
« on: June 30, 2020, 11:13:40 pm »
Hi Everyone, I hope all is well!

After 4 regimens in my first 18 months and ongoing blood pressure spikes through all of them, I analyzed my meds further, Noticing that every one of them contained an NRTI

I brought this to the attention of my doctor and asked if Juluca should be an option... but he seemed that if NRTI is giving me problems, It may be the same with NNRTI since they take the same pathway.

so far
Biktarvy, isentress with descovy, odefsey, dovato

My doctor has me on a 30-45 day holiday to see if my blood pressure spikes subside.

In the mean time I am curious about my other options and want some insight so I can participate in my doctors suggestions of regimans. I am no expert, but am nervous that almost every regimen has these components.

Are protease inhibitors just as safe? Are older drugs safe? anything very new that excludes NRTI and NNRTI's?

Tha last thing I want is a more dangerous cocktail, but if these newer combos are not resting with my body I have no choice.

Any thoughts? recommendations?

I am thinking to try and see 1 or 2 new ID docs and get their suggestions to discuss with my primary ID doc.

Am I hopeless and out of options or are there good safe options? a shot or a 2 drug?

If you think an NNRTI will not have similar problem and NRTI, please let me know... I was really thinking Juluca might have been a good option.

Also if you had blood pressure spikes (mine always happen when I go to sleep) from meds, what was your solution or the med that helped you?

Thanks everyone for any feedback that will help me participate in my doctors selections and have an intelligent conversation with him as well.

Offline LauderdaleDennis

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Re: Choices outside of NNRTI and NRTI
« Reply #1 on: July 03, 2020, 04:15:28 pm »
clearly posting in this forum has become a waste of time. I am sure this will be read and deleted.

Offline Jim Allen

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Re: Choices outside of NNRTI and NRTI
« Reply #2 on: July 03, 2020, 05:06:15 pm »
Well only speaking for myself, at this point i just have nothing to add that I've not already said on your original thread. https://forums.poz.com/index.php?topic=73221

Not sure what you mean with it with it will be deleted? Anyhow nothing wrong with drugs in the past as such, plenty of people used them without any issues and like anything it did not agree with others.
« Last Edit: July 03, 2020, 05:13:15 pm by Jim Allen »
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Offline virgo313

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Re: Choices outside of NNRTI and NRTI
« Reply #3 on: July 03, 2020, 05:31:35 pm »
Was reading your original thread too. Again, should ask ur Dr n this. Everyone react differently to meds. What was your latest Dr advise? Personally I think switching too many Dr writhing your short period after starting taking meds is not good. Tks
RVD Nov 2015. VL --> Log 5.32 HAART on 23/11/15
TDF+FTC+EFV / Chemo KS - 25/11/15 - 20/01/16.
CD4 - 4 (3/11/15) / VL - 225,000

Offline wardp

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Re: Choices outside of NNRTI and NRTI
« Reply #4 on: July 06, 2020, 10:36:30 am »
Are you sure it's your meds? Have you heard off nocturnal blood pressure.i have it.daytime it's fine but when I check on awakening it's high. Sleep apnea and poor sleep can also cause it.
Diagnosed 20,July 2017. Cd4 289, 21% vld .3,462 Started atripla 4 Aug 2017 5oct 2017 cd4 384 21%, vl ud less than 20. Switch to complera 4 Nov 2017 switched to stribild 15 the Nov. Switched to truvada efavirence 200mgx2 14 Dec 2017, 2 Feb 2018, us cd4  466, 25%  CD 8 ,595, 32%..1 may 2018
switched  to instgra truvada.7th june switched to truvada  nevirapine stavudine. .21 june switched to truvada nevirapine. X 2 a day...9 aug 2018 ud. 2n Nov 2018 CD 4. 455..22.70% 13th Nov switched  to lamivir and nevirapine  due to kidney issues...jan 10,2019 UD..may 13 2019 ud  cd4 482 28% 14th nov 2019 ud. Cd4 414 .27% cd8 444 29%,may 16 2020,ud ,cd4 741"19.62.


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