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Author Topic: Acriptega  (Read 445 times)

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Offline edu123

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« on: April 21, 2020, 02:57:51 pm »
My doctor has just switched me to Acriptega, I was on Truvada, Atazor (Atanazavir 300mg) & Norvir before, and before that on Kaletra (Aluvia) & Truvada. The changes are primarily suggested for convenience of taking the meds.

That said, I do not see Acriptega on the list of meds on the POZ site. Browsing the net, there is also very little indication in terms of people taking this drug. Is it because it may not be as good a drug especially considering recent reports of Dolutegravir increasing the risk of Neural Tube Defects?

Offline Jim Allen

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Re: Acriptega
« Reply #1 on: April 21, 2020, 03:13:21 pm »

Welcome to the forums.
How are you getting on asides from the switching?

Acriptega is something you would not see listed on POZ.com. It's grand though, the pill is just a combination of Dolutegravir, Lamivudine, and Tenofovir. DTG is mixed with these other drugs plenty in other treatment options.

Is it because it may not be as good a drug especially considering recent reports of Dolutegravir increasing the risk of Neural Tube Defects?

DTG is even recommended as first-line treatment, in a number of combinations with plenty of data available. In regards to pregnancy, I've added a few references.

Have you spoken to your doctor about your concerns? If so, what did they say?

Best, Jim 

In full: https://www.poz.com/article/pregnant-women-hiv-dolutegravirbased-regimens-apparently-safest

In Short:

Antiretroviral (ARV) regimens based on the integrase inhibitor dolutegravir are apparently the safest and most effective treatments for pregnant women living with HIV. So found a large multinational study that compared Atripla (efavirenz/tenofovir disoproxil fumarate/emtricitabine) versus dolutegravir plus either Descovy (tenofovir alafenamide/emtricitabine) or Truvada (tenofovir disoproxil fumarate/emtricitabine).

In full:

In Short:

Based on new evidence assessing benefits and risks, the WHO recommends the use of the HIV drug dolutegravir (DTG) as the preferred first-line and second-line treatment for all populations, including pregnant women and those of childbearing potential.

New data from two large clinical trials comparing the efficacy and safety of DTG and EFV in Africa have now expanded the evidence base. The risks of neural tube defects are significantly lower than what the initial studies may have suggested.

« Last Edit: April 21, 2020, 03:43:03 pm by Jim Allen »
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