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Author Topic: Toink2 Introduction & Cd8 question  (Read 633 times)

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Offline Toink2

  • Member
  • Posts: 3
Toink2 Introduction & Cd8 question
« on: May 28, 2020, 04:20:47 pm »
Hi Jim and Carlos

I registered as a member of this forum in October 2018 (the day I was diagnosed with HIV) but I barely understood anything the members were discussing. I don't think I understand enough now, but after 19 months of being on meds and gathering information about HIV, I can follow most of the discussions in this forum and this is my first post :D. And I am not too confident of my english, which gives me a hard time understanding the discussions (add lots of medical terms and I am often lost)

Relating to this topic about high CD8 count, I have done my best searching on this forum, and I got this : High CD8 means you currently have some infection. After reaching Undetectable Viral Load CD8 count will go down.

This is my case :

October 2018 :
diagnosed and started Efavirenz 600mg Tenofovir 300mg Lamivudine 300mg
CD4 count 330, VL count 237,000 CD8 not tested
Syphilis tested negative

March 2019 :
CD4 421, CD8 938, VL 60 no other tests

May 2019
CD4 567, CD8 1499, VL undetectable no other tests

October 2019
VL undetectable (CD4 and CD8 not tested) no other tests

December 2019 I had red rash and I went for Syphilis test > turned out positive
Injected Penicillin then rash disappeared within days. I assume it was cured.

May 2020
CD4 900, CD8 1968, VL undetectable forgot to ask for syphilis test

I only skipped one day without medication since October 2018.
Do you think I still have Syphilis or other infection, looking at high cd8? Or is it okay to have cd8 this high?

Thank you

Offline Expat1

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  • Posts: 358
Re: Toink2 Introduction & Cd8 question
« Reply #1 on: May 28, 2020, 08:33:55 pm »
As I understand it, the cd8 is "normally" lower than CD4 in people without infection,  HIV flips the ratio so that it is often a ratio of 1st CD cell and 2 CD8 cells.   

After treatment sometimes it goes back to a 1:1 ratio.

That said in 7 years of successfully suppressing my HIV to undetectable, my CD8 has always been about double my CD4.

For some people it never goes down.  It does t really men much.  Many doctors don't even check it because it does not change the treatment you get or predict anything.

CD8 cells are killer T cells.  They attack infection.  I have autoimmune  issues so they are always high.

Basically my advice, forget about them.

Viral Load to Undetectable is the main goal of treatment.

My doctor only looks at CD 1 time each year As mine has always been above 500.

Hope that helps.

Offline Almost2late

  • Member
  • Posts: 1,235
Re: Toink2 Introduction & Cd8 question
« Reply #2 on: May 28, 2020, 09:11:37 pm »
From my understanding cd8 is not a concern with HIV positive people. It's the cd4's that are, and yours are great. Then there's the viral load, and you are undetectable so you do not have any issues.

I don't even know what my cd8's are and I really dont care.. if it's an issue my doctor I'm sure would address it.

Offline Tonny2

  • Member
  • Posts: 2,326
Re: Toink2 Introduction & Cd8 question
« Reply #3 on: May 28, 2020, 10:02:25 pm »

       ojo.        Hello there, welcome through the forum... May I know what language do you speak?... Any doubt you may have to be sure, ask your doctor. Usually we are only concern about cd4 and viral load. You are ud which means that your treatment is working end it is the most important... Forgive my English, it is my second language... Best of luck, please keep us posted...hugs

Offline daveR

  • Member
  • Posts: 161
Re: Toink2 Introduction & Cd8 question
« Reply #4 on: May 29, 2020, 07:50:30 am »
My Doctor does not check the CD8 count. I have paid for seperate tests myself. Much like CD4's, they vary a lot. Some times my ratio is in normal range, other times the ratio is low as i have a high CD8 count. As my Doctor is not bothered by them I stopped having additional tests. I understand that a high count can be classified as inflamation, I may be wrong. But I also think there is not much to be done.
As long as you are undetectable with normal CD4 count do not worry about it.

Offline Toink2

  • Member
  • Posts: 3
Re: Toink2 Introduction & Cd8 question
« Reply #5 on: May 31, 2020, 02:58:54 pm »
Massive thanks for your replies guys. I can cast away my worries now :D

Expat1 : Yes the information I gathered so far was : cd8 SHOULD get back down after UVL. I have eczema and asthma too, if high cd8 is caused by these two, as you suggested, let's not worry anymore :D

Almost2late : Some labs do not even bother to check cd8 (I never asked in the first place though at the ones that do though hahah) I guess you are right we should only see our cd4 count

Tonny2 : I speak Indonesian. We should be proud of our 1st language hahah

daveR : So your cd4:cd8 ration has gone up and down? Yeah I was concerned about possible inflammation or infection or as expat1 mentioned, autoimmune issue. I am thinking of visiting a HIV specialist doctor in town hoping he can explain anything. General practitioners (like the one I have been visiting to get HIV medication so far) are not well informed about this


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