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Author Topic: Both of my CD level and viral load increased  (Read 878 times)

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Offline metekrop

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  • Posts: 422
  • Is time running fast for you.
Both of my CD level and viral load increased
« on: February 28, 2020, 09:27:26 am »
I achieved the highest CD level of 920 (if it is an achievement?) since I put on Aripla back in 2008 and my viral load increased a little to 70.  I am WORRIED by the fact that my viral load is now 70 which I thought is no-virus in my blood since it was undetected the last twelve years. When I ask my doctor he told me that I should not worried about and this it may happen because of latest infections.  So, is there anyone here who has such experience of having elevated viral load after twelve or more years of undetectable result.     
Diag.on 12/8, 2000, CD 440 VL 44K, No Meds
12/08 - 2/09 CD< 50 & VL >500k hosp'z.
St. Atripla - 7/09 CD 179, VL 197k
10/09 CD 300 VL U
3/10 CD 468 U
8/10 CD 460 U
12/10 CD 492 U
3/11 CD 636 U
8/11 CD 530 U
1/12 cd 616 U
7/12 CD 640 U
12/12 CD 669 U
5/13 CD711 U
11/13 663 U
4/14 CD 797 U
10/14 CD 810 U
4/15 CD 671 U
10/15 CD 694 U
3/16 CD 768 U
8/16 CD 459 U
2/22 CD 780 U
8/31 CD 940 U
2/26 CD 809 U
8/18 CD 882 U
3/28 CD 718 U
8/15 CD 778 U
2/25 CD 920 70
8/11 CD 793 U

Offline silguy618

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  • Posts: 38
Re: Both of my CD level and viral load increased
« Reply #1 on: February 28, 2020, 10:03:14 am »
I'm following this also
« Last Edit: February 28, 2020, 10:05:56 am by silguy618 »

Offline zach

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Re: Both of my CD level and viral load increased
« Reply #2 on: February 28, 2020, 01:02:27 pm »
One lab result is statistically irrelevant, look at trends over the course of three or more results.

You had a blip, it certainly doesn't indicate treatment failure. Too many unknown variables to even try to glean what caused the blip.

Do you trust your doctor, have a good relationship and open communication with them? If so, listen to them, don't worry.

Offline metekrop

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  • Is time running fast for you.
Re: Both of my CD level and viral load increased
« Reply #3 on: February 28, 2020, 02:05:26 pm »


You had a blip,

How does this blip is happening?  Every five years, seven or twelve..?  You all know that living with HIV is a very terrible thing.   What do you think except worrying when your viral load is jumping all of a sudden from undetectable to 70 where I know I am adhering to my meds. 
Diag.on 12/8, 2000, CD 440 VL 44K, No Meds
12/08 - 2/09 CD< 50 & VL >500k hosp'z.
St. Atripla - 7/09 CD 179, VL 197k
10/09 CD 300 VL U
3/10 CD 468 U
8/10 CD 460 U
12/10 CD 492 U
3/11 CD 636 U
8/11 CD 530 U
1/12 cd 616 U
7/12 CD 640 U
12/12 CD 669 U
5/13 CD711 U
11/13 663 U
4/14 CD 797 U
10/14 CD 810 U
4/15 CD 671 U
10/15 CD 694 U
3/16 CD 768 U
8/16 CD 459 U
2/22 CD 780 U
8/31 CD 940 U
2/26 CD 809 U
8/18 CD 882 U
3/28 CD 718 U
8/15 CD 778 U
2/25 CD 920 70
8/11 CD 793 U

Offline harleymc

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  • Posts: 1,411
Re: Both of my CD level and viral load increased
« Reply #4 on: February 28, 2020, 05:16:50 pm »
I got a vl count if 18000 one time after undetectable viral loads for 6 years.

If you're worried about 70 you could get your semi annual test moved forward to 3 months.

Offline Jim Allen

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Re: Both of my CD level and viral load increased
« Reply #5 on: February 28, 2020, 08:01:11 pm »
Hiya,

I agree with Zach. Looks like a micro blip and can happen and, if it was my own lab results I would not be worried.

Tiny blip could be getting over other infections/illness like you doctor pointed out, it depends, an example I can recall once I had 10 days ahead of labs a vomiting bug. It took me a full week to recover and I had a slight blip when doing labs. I just put it down to dosing issues given I had been vomiting non-stop for a week.

Also most likely if you had your VL taken daily over the past 12 years you would have seen such blips from time to time, it just happens you caught one out on the 6 monthly check.
 
In addition, there is the theory if there is good adherence micro blip could be due to a release from the viral reservoir including defective copies being counted.

Best, Jim

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308904/

3550 participants blips of 500999 copies/mL were associated with virologic rebound, whereas blips of 50499 were not.

This 3 pager is worth reading through as it gives some great real-life context to blipping. https://www.healio.com/infectious-disease/hiv-aids/news/online/%7B8373ca63-674d-4015-ac35-f4da653c7415%7D/qa-understanding-persistent-low-level-viremia-in-people-with-hiv

Defective copies - 90℅ or more of HIV in reservoirs are rejects
https://www.sciencedaily.com/releases/2016/08/160808150523.htm
« Last Edit: February 28, 2020, 08:53:22 pm by Jim Allen »
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Offline leatherman

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Re: Both of my CD level and viral load increased
« Reply #6 on: February 28, 2020, 09:08:29 pm »
I got a vl count if 18000 one time after undetectable viral loads for 6 years.
in a 6 month period I blipped to 1500, 2500 and then to 79000 (and my cd4s dipped back into the very low 100s). Did a genotype test and my meds that had keep me UD for 6 years were still working. The next test had me back to UD, and a cd4 count of 435 (my third highest count in 27 yrs!).

Quote
In addition, there is the theory if there is good adherence micro blip could be due to a release from the viral reservoir including defective copies being counted.
yep. several blips through 27 years of meds before returning to normal. Like any other blood test, a single result is just a snapshot at the moment of testing for a body that is constantly in flux.

which I thought is no-virus in my blood since it was undetected the last twelve years.
that's not how it works. You'll always have HIV, as there is no cure. The HIV meds just keep it suppressed (interrupting it in various stages of the life cycle) so that it is usually "undetectable". (BTW clinically 200 is still consider "undetectable", so 70 means nothing statistically). There is always some HIV in your system somewhere. After HIV is suppressed, the remaining HIV "hides" out in reservoirs that are usually latent. Occasionally the HIV can start to build up again; but of course, while you are adherent to meds, this HIV is killed off. The tricky part is if you go get a blood test right as some of that HIV in the reservoirs "leaks" out, a tiny bit of HIV may be counted. Oh no. :D if you had only had your blood tested the day before, or even an hour later, it might not have even registered.
leatherman (aka mIkIE)

Offline metekrop

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  • Posts: 422
  • Is time running fast for you.
Re: Both of my CD level and viral load increased
« Reply #7 on: March 02, 2020, 01:38:47 pm »
Thank you friends here who schooling me on the things that worry me much.  Thank you again !!!
Diag.on 12/8, 2000, CD 440 VL 44K, No Meds
12/08 - 2/09 CD< 50 & VL >500k hosp'z.
St. Atripla - 7/09 CD 179, VL 197k
10/09 CD 300 VL U
3/10 CD 468 U
8/10 CD 460 U
12/10 CD 492 U
3/11 CD 636 U
8/11 CD 530 U
1/12 cd 616 U
7/12 CD 640 U
12/12 CD 669 U
5/13 CD711 U
11/13 663 U
4/14 CD 797 U
10/14 CD 810 U
4/15 CD 671 U
10/15 CD 694 U
3/16 CD 768 U
8/16 CD 459 U
2/22 CD 780 U
8/31 CD 940 U
2/26 CD 809 U
8/18 CD 882 U
3/28 CD 718 U
8/15 CD 778 U
2/25 CD 920 70
8/11 CD 793 U

 


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