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Author Topic: Steady decline of globulin levels while on Tenofovir  (Read 926 times)

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Offline frederick

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Steady decline of globulin levels while on Tenofovir
« on: December 16, 2019, 01:28:26 pm »
Anyone else experience a steady decline in blood globulin levels? Mine went from a high of 30 g/L before I started my meds (Efavirenz, Lamivudine and Tenofovir) to 20 g/L as of today (Normal range is 23 to 35)..  I've also noticed my urine is foamier than usual (think beer foam). Urine albumin and micro-albumin tests are both negative .. Other kidney markers are also unremarkable..

I read somewhere that urine microglobulin is a better marker for early kidney damage from tenofovir. Unfortunately, we don't have the said test in my country..

Just wondering if anyone here was made to switch to another regimen by their doctor due to declining globulin level while on tenofovir?

Offline Jim Allen

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #1 on: December 16, 2019, 01:45:57 pm »
I thought you were going to switch a few weeks ago? Did that not happen or did I misunderstand?

Anyhow, 20 is not fastly out at least I thought 20-30 was the average range. What did the doc say about the result and switching?

Best, Jim
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Offline frederick

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #2 on: December 16, 2019, 02:14:00 pm »
Hey Jim. I was able to purchase the meds already but I haven't started taking it. I'm holding off on switching until I'm absolutely sure that it's necessary. My doc doesn't recommend I switch cause my current regimen is working well in terms of suppressing VL. He also thinks the falling globulin level is no cause for alarm and that my foamy urine is due to how I "metabolize" the drugs. I'm not buying it that's why I'm here to ask for inputs from other members :)

Offline Jim Allen

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #3 on: December 16, 2019, 02:50:28 pm »
Well, like most of us you have your Doctor's medical opinion to help guide you, but ultimately the decision to switch or not is totally yours.

Best, Jim

P.S

If you don't mind me asking and purely out of interest what drug combo did you end up getting for the potential switch? You mentioned a few combos's in the last thread. https://forums.poz.com/index.php?topic=73242
« Last Edit: December 16, 2019, 02:58:25 pm by Jim Allen »
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Offline frederick

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #4 on: December 17, 2019, 04:46:17 am »
Well, like most of us you have your Doctor's medical opinion to help guide you, but ultimately the decision to switch or not is totally yours.

Best, Jim

P.S

If you don't mind me asking and purely out of interest what drug combo did you end up getting for the potential switch? You mentioned a few combos's in the last thread. https://forums.poz.com/index.php?topic=73242

I decided on DOVATO to do away with tenofovir completely. I hope I made the right choice

Offline wardp

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #5 on: December 17, 2019, 05:51:45 pm »
I've been of tenofovir about a year and  my creatinine clearence is still in the 60s before I started tenofovir it was in the 90s. Not sure if this is related to tenofovir or just getting old?
Diagnosed 20,July 2017. Cd4 289, 21% vld .3,462 Started atripla 4 Aug 2017 5oct 2017 cd4 384 21%, vl ud less than 20. Switch to complera 4 Nov 2017 switched to stribild 15 the Nov. Switched to truvada efavirence 200mgx2 14 Dec 2017, 2 Feb 2018, us cd4  466, 25%  CD 8 ,595, 32%..1 may 2018
switched  to instgra truvada.7th june switched to truvada  nevirapine stavudine. .21 june switched to truvada nevirapine. X 2 a day...9 aug 2018 ud. 2n Nov 2018 CD 4. 455..22.70% 13th Nov switched  to lamivir and nevirapine  due to kidney issues...jan 10,2019 UD..may 13 2019 ud  cd4 482 28% 14th nov 2019 ud. Cd4 414 .27% cd8 444 29%

Offline Jim Allen

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #6 on: December 18, 2019, 01:43:59 am »
I decided on DOVATO to do away with tenofovir completely. I hope I made the right choice

Okay. well if you do decide to switch keep us posted on that.
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Offline Mindless

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #7 on: December 19, 2019, 11:15:36 am »
I've been of tenofovir about a year and  my creatinine clearence is still in the 60s before I started tenofovir it was in the 90s. Not sure if this is related to tenofovir or just getting old?

Mine dropped from 90s to 70s since starting TDF (2.5 years ago). Dr seems not to worry till ups are over 60, though Iím starting to worry now. Iím 50 yo, normal range for age bracket is over 90. Will take an eye on the next blood tests and decide what to do.

Hugs

Offline frederick

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #8 on: December 20, 2019, 11:39:36 am »
Mine dropped from 90s to 70s since starting TDF (2.5 years ago). Dr seems not to worry till ups are over 60, though Iím starting to worry now. Iím 50 yo, normal range for age bracket is over 90. Will take an eye on the next blood tests and decide what to do.

Hugs

My creatinine level is actually on a downtrend since starting TDF almost 2 years ago. I can only surmise that my daily consumption of lemon water (a natural diuretic) and a curcumin supplement helped in achieving this. I've also reduced my consumption of red meat. You might wanna give them a shot

Have you had the chance to test your globulin level?   

Offline frederick

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #9 on: December 20, 2019, 03:06:10 pm »
I've been of tenofovir about a year and  my creatinine clearence is still in the 60s before I started tenofovir it was in the 90s. Not sure if this is related to tenofovir or just getting old?

It could be tenofovir. Are you on TDF or TAF?

Offline venom_X

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #10 on: December 21, 2019, 03:08:02 pm »
I have the exactly opposite situation. My serum globulin levels increased a lot (now to 3.7 g/dL) since I got infected. I can't tell if it's due to the medication or due to the infection itself since I started the treatment 2 weeks post infection.

Wondering if anyone else has experienced increase in the serum globulin levels.
Infected Mid June, 2019
Acute syndrome late June, started Biktarvy
3 weeks post infection (1 week on ART): VL: 330k, CD4 400 (33%), CD8 460, CD4/CD8 ratio: 0.9
5 weeks pi: VL: 300, CD4: 500 (30%), CD8: 690, ratio: 0.7
8 weeks: VL: 30,  CD4: 590 (28%), CD8: 920, ratio: 0.6
12 weeks: VL <30, CD4: 750 (37%), CD8: 700, ratio 1.1
20 weeks: VL<30, CD4 550 (dropped from 750 from 2 months ago, 38%), CD8 450, Ratio 1.2, elevated liver enzymes

Offline Mindless

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #11 on: December 22, 2019, 06:58:47 am »
My creatinine level is actually on a downtrend since starting TDF almost 2 years ago. I can only surmise that my daily consumption of lemon water (a natural diuretic) and a curcumin supplement helped in achieving this. I've also reduced my consumption of red meat. You might wanna give them a shot

Have you had the chance to test your globulin level?

Will take the eGFR monitored.  Thanks for the advice will check it. Globulin level? Not sure about that, something they do during routine blood work?

Hugs

Offline harleymc

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Re: Steady decline of globulin levels while on Tenofovir
« Reply #12 on: January 03, 2020, 02:31:54 pm »
Which tenofovir?

 


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