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Author Topic: Lactobacillus spp. - GALT - Gut Permeability  (Read 277 times)

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Offline ZachR

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  • Let's look at the stars again
Lactobacillus spp. - GALT - Gut Permeability
« on: November 28, 2019, 06:05:28 am »
There are two papers with, from a scientific standpoint, shattering discoveries.

Paper One:
The exact same, very important, receptor protein CD4 was detected on commensal bacteria of Lactobacilli. Even though the clinical implocations are yet unclear, the mere fact that evolutionarily so distanced from us bacteria express the same very important receptor protein on their surface is admirable. They can bind HIV without being able to ensure the further steps of the infection, thus creating a false target and sparing GALT. 

Paper Two:
Bacterial translocation is admittedly among the greatest pathologies driven by HIV-associated damage on the intestinal integrity that causes immune activation and inflammation. Lactobacillus plantarum appears to be able to restore this damage thru a mitochondria-associated pathway.

Science is fascinating, hope, more funds go into such research.

References:
https://www.sciencedirect.com/science/article/pii/S0944501312001437
https://www.sciencedaily.com/releases/2019/11/191119143246.htm
25.10.19 VL 43
26.05.19  CD4+ 685 %26 VL 55
27.03.19  CD4+ 850 %31 VL 24
***Switched to Biktarvy due to side effects.
25.02.19  CD4+ 740 %30 VL 78
15.01.19  CD4+ 1600(might be wrong) %0.7 VL 54
05.11.18  CD4+ 720 VL 1,100
17.09.18  CD4+ 962 %25 VL 14,000,000 - Started first regimen on Triumeq
15.07.18 - diagnosed, CD4+ 490 %20
20.04.18 - infected

https://ibb.co/X74GV0X

Online Jim Allen

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Re: Lactobacillus spp. - GALT - Gut Permeability
« Reply #1 on: November 28, 2019, 06:30:10 am »
Live cultures and gut issues is an old HIV/AIDS tip, but staying on topic about the gut, bacteria and how it interacts with HIV with regards to inflammation, the damage has always been interesting and I suppose there is always more to learn

Included some related stuff for you if you are interested

https://forums.poz.com/index.php?topic=55493.msg650730#msg650730
http://www.aidsmap.com/news/aug-2014/novel-immune-suppressant-vaccine-completely-blocks-hiv-infection-monkeys-human-trials

- Lactobacillus genus, appears to work by stimulating the production of a previously unknown group of CD8 T-cells that, while recognising HIV themselves, stopped the monkeys’ CD4 cells from recognising SIV as a foreign invader, thereby preventing an immune response to SIV. This suppressant effect – which works in the opposite way to a traditional vaccine – means that the SIV is deprived of the SIV-specific immune-activated CD4 cells it needs in order to proliferate and establish an infection in the body.     

2016
https://forums.poz.com/index.php?topic=62080.msg699564#msg699564
Probiotic improves gut barrier function in patients with HIV

Probiotic supplementation improved the physical and immunological integrity of the intestinal mucosal barrier in HIV-1-positive patients being treated with antiretroviral therapy, according to new research.

2006
Doctors modify yoghurt bacteria to combat HIV infection
http://www.abc.net.au/pm/content/2006/s1550503.htm



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Offline ZachR

  • Member
  • Posts: 58
  • Let's look at the stars again
Re: Lactobacillus spp. - GALT - Gut Permeability
« Reply #2 on: November 28, 2019, 06:39:24 am »
I'd never stumbled upon such a study about Lactobacillus spp. effect on CD8s, which are also major players. That publication is invaluable! Thank you, Jim!
25.10.19 VL 43
26.05.19  CD4+ 685 %26 VL 55
27.03.19  CD4+ 850 %31 VL 24
***Switched to Biktarvy due to side effects.
25.02.19  CD4+ 740 %30 VL 78
15.01.19  CD4+ 1600(might be wrong) %0.7 VL 54
05.11.18  CD4+ 720 VL 1,100
17.09.18  CD4+ 962 %25 VL 14,000,000 - Started first regimen on Triumeq
15.07.18 - diagnosed, CD4+ 490 %20
20.04.18 - infected

https://ibb.co/X74GV0X

 


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