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Author Topic: American Gene Technologies believes they have the cure for HIV/AIDS  (Read 711 times)

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Offline em

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I do not know if this has already been posted ? but it is relatively new news from nov 6
I know cure hype  believe it when you see it  thought this info might be worth sharing

https://www.localdvm.com/news/i-270/american-gene-technologies-believes-they-have-the-cure-for-hiv-aids/

Offline Mindless

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #1 on: November 08, 2019, 08:34:24 am »
Quote
AGT should hear from the FDA sometime before the end of the year. If its approved, they will have the green light to begin phase one of the clinical trial in January.

I guess this means that even if this is actually working (yet to be demonstrated) wed be years maybe decades away from real world application (at what cost is another big question), is that correct?

Offline Jim Allen

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #2 on: November 08, 2019, 08:38:58 am »
https://forums.poz.com/index.php?topic=73181.msg762655#msg762655

Someone mentioned it, it's just another nice idea like so many and throwing the word cure around for investment & buzz.

Anyhow it's going into a phase 1 study, I'll find you a better link thought later today then the one you have



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Offline geobee

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #4 on: November 08, 2019, 05:22:08 pm »
I participated in something similar a while back.  A company, Sangamo, was going to use ZFN (Zinc Finger Nuclease) to edit T-Cells. The idea was to collect your T-Cells through apheresis, modify them, and put them back.  The resistant cells would survive and be immune to HIV. 

I was eventually DQ'd from the study.  Didn't have enough HIV in my blood apparently.  So they couldn't tell if it was CCR5 or not.

From what I read, this is similar.  Take your cells out, modify them to produce an AB, and put them back.  Pretty cool. 

This process is a lot less scaleable then a pill / vaccine of course.  Apheresis takes about two hours and, while not unpleasant, wasn't particularly comfortable.  Still, if this thing shows promise, sign me up! 

Offline ZachR

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #5 on: November 08, 2019, 06:14:43 pm »
It is a nice one and has made it to human trials. There is some good likelyhood for it to reach phase II and III and hope it does, but one of the potentially serious obstacles would be:
a/ no measurable effect
b/ even if it happens to work, will take at least 5 years to be available if given priority.
c/ serious immunogenicity, which could lead to a pronounced inflammatory effect throughout the body with potential consequences like organ damage and failure.
Only speculating tho, lentiviral vector technology is promising for many diseases, let's hope it grants us a safe functional cure. Even if it doesn't though, it will answer many questions that will help get closer to the real 'cure'.
« Last Edit: November 08, 2019, 06:18:58 pm by ZachR »
25.10.19 VL 43
26.05.19  CD4+ 685 %26 VL 55
27.03.19  CD4+ 850 %31 VL 24
***Switched to Biktarvy due to side effects.
25.02.19  CD4+ 740 %30 VL 78
15.01.19  CD4+ 1600(might be wrong) %0.7 VL 54
05.11.18  CD4+ 720 VL 1,100
17.09.18  CD4+ 962 %25 VL 14,000,000 - Started first regimen on Triumeq
15.07.18 - diagnosed, CD4+ 490 %20
20.04.18 - infected

https://ibb.co/X74GV0X

Offline Expat1

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #6 on: November 09, 2019, 03:18:18 pm »
IF a treatment cured say 90% of people living with HIV, but killed the other 10 %, would you sign  up?

What if it cured 99% and killed only 1%?

What it the final cost/benefit level that is acceptable?  And compare that to current
practices with ART?

No answer from me?  Just a question.

(Maybe only  use with  multidrug resistant HIV after salvage therapy unable to reduce VL below a certain threshold?)

Offline ZachR

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  • Let's look at the stars again
Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #7 on: November 09, 2019, 04:48:02 pm »
IF a treatment cured say 90% of people living with HIV, but killed the other 10 %, would you sign  up?

What if it cured 99% and killed only 1%?
 

If it killed 10% it wouldn't be approved for widespread use anyway. In case it killed 1% while successfully curing 99, it would be approved, because numerous interventions used in medicine already have a worse risk/benefit ratio than 99/1.

Let me only remind you that we don't have a 100% guarantee that we'll make it till tomorrow, right?  So demanding 100% from those guys would be unnatural.
« Last Edit: November 09, 2019, 04:52:24 pm by ZachR »
25.10.19 VL 43
26.05.19  CD4+ 685 %26 VL 55
27.03.19  CD4+ 850 %31 VL 24
***Switched to Biktarvy due to side effects.
25.02.19  CD4+ 740 %30 VL 78
15.01.19  CD4+ 1600(might be wrong) %0.7 VL 54
05.11.18  CD4+ 720 VL 1,100
17.09.18  CD4+ 962 %25 VL 14,000,000 - Started first regimen on Triumeq
15.07.18 - diagnosed, CD4+ 490 %20
20.04.18 - infected

https://ibb.co/X74GV0X

Offline Expat1

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #8 on: November 09, 2019, 09:56:57 pm »
Zack, I asked: "Would you sign up?"   Not if it would be approved.  Me no.

IF my CD4 were 25 and I was symtomatic with OIs, maybe. 

Offline em

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #9 on: November 09, 2019, 11:39:36 pm »
that was me over twenty years ago when my ID doc suggested I go on trial testing norvir.   My count was 7 viral load inconceivable large    that i gladly tried thinking even if I die at least I gave every option a try if it did not help me it might help others on the same path .    I would be willing to be selected to try this .  to help push things toward a cure .   I cannot see why anyone would not want to but that is your choice

I hope we live to see this turn out to be cure for everyone's sake 

em

Offline Expat1

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #10 on: November 10, 2019, 04:36:45 am »
Good points em. 

Whenever I see cure in the headlines with HIV , first thing I think is that it is probably a pump and dump scheme or someone wanting to make a fortune with  an IPO.   

Call me skeptical.

Offline Jim Allen

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Re: American Gene Technologies believes they have the cure for HIV/AIDS
« Reply #11 on: November 10, 2019, 05:06:34 am »
Good points em. 

Whenever I see cure in the headlines with HIV , first thing I think is that it is probably a pump and dump scheme or someone wanting to make a fortune with  an IPO.   

Call me skeptical.

I'm with you on that, every year the next big "cure" is announced and for decades nothing has panned out. If I had been a mouse, monkey or petri-dish I would have been cured a dozen times over mind you.  ;D

Scientifically it's fascinating stuff, take the "Research News & Studies" section if you like and you search for the keyword "cure" you will find decades of exciting announcements about cures some of them at human testing stages that simply did not work out. It's great we keep learning from this stuff though in the sense of scientific development

For me getting excited or hopeful every time would be an utter waste of energy & life. Worse is the odd cases of people not starting treatment or stopping as they believe there is or will be a cure soon or people taking risks because of cure headlines  😡
« Last Edit: November 10, 2019, 05:22:33 am by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

 


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