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Author Topic: weight gain on Biktarvy  (Read 1808 times)

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Offline venom_X

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  • Posts: 28
weight gain on Biktarvy
« on: October 30, 2019, 02:54:30 pm »
After the recent batch of research came out on the DTG's impact on weight gain, I myself experienced it first hand and want to check if anyone else has noticed similar.

On Biktarvy now for 4 months now and I gained about 10 lbs. I could literally feel that a beer belly is forming (which I never had before in my life). The LDL and trig levels stay about the same.

I have tried to increase exercise and be more mindful about diet but doesn't seem to notice any impact yet.
Infected Mid June, 2019
Acute syndrome late June, started Biktarvy
3 weeks post infection (1 week on ART): VL: 330k, CD4 400 (33%), CD8 460, CD4/CD8 ratio: 0.9
5 weeks pi: VL: 300, CD4: 500 (30%), CD8: 690, ratio: 0.7
8 weeks: VL: 30,  CD4: 590 (28%), CD8: 920, ratio: 0.6
12 weeks: VL <30, CD4: 750 (37%), CD8: 700, ratio 1.1
20 weeks: VL<30, CD4 550 (dropped from 750 from 2 months ago, 38%), CD8 450, Ratio 1.2, elevated liver enzymes

Offline harleymc

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  • Posts: 1,361
Re: weight gain on Biktarvy
« Reply #1 on: October 30, 2019, 08:48:59 pm »
I've picked up a kilo (2.2 lbs), yep it's all belly.  Haven't had a drink in 4 months and very sparing on the treats at work.

Offline BlueMoon

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  • Calling from the Fun House
Re: weight gain on Biktarvy
« Reply #2 on: October 31, 2019, 11:58:26 am »
I have gained no weight in the nine months since I began taking Biktarvy.

Your weight increase could be due not to the medication, but because the HIV is suppressed.  If your metabolism has changed so that you gained ten pounds in four months, then you are consuming 300 calories a day more than you need.  If you reduce your intake (or increase your activity) by that amount, you should stop gaining weight but will not lose any. 

What is a DTG?



It's a complex world

Offline Jim Allen

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Re: weight gain on Biktarvy
« Reply #3 on: October 31, 2019, 01:35:14 pm »
What is a DTG?

Dolutegravir.

@OP My experience is I gained some weight on Dolutegravir but it was needed and it settled, few years later stable weight and then I gained again but this recent round it was just diet & ageing so a quick diet adjustment fixed that .


Your weight increase could be due not to the medication, but because the HIV is suppressed. 


Yup, many possible factors to gaining weight particularly when it's somebody new to treatment

Jim

https://www.poz.com/article/hiv-may-lead-big-belly

HIV May Lead to a Big Belly
A recent study found that the virus was associated with abdominal obesity as well as high triglycerides and low LDL cholesterol.

https://www.poz.com/article/starting-hiv-treatment-women-gain-weight-men

https://www.poz.com/article/weight-gain-immune-activation-may-linked-people-hiv

https://www.poz.com/article/normal-weight-gain-switch-integrase-inhibitors

https://www.poz.com/article/integrase-inhibitors-may-tied-weight-gain

https://www.poz.com/article/switching-new-version-antiretroviral-tenofovir-may-lead-weight-gain

https://www.aidsmap.com/news/mar-2015/does-hiv-make-you-fat-study-connects-viral-load-fat-gains



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Offline venom_X

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  • Posts: 28
Re: weight gain on Biktarvy
« Reply #4 on: October 31, 2019, 03:13:29 pm »
Wow thanks for the insights and information. Well in my case it could also be the fact that due to the acute infection, I lost about 4-5 lbs within two weeks and gained those back and more once on treatment. Just the weight loss during the acute phase is likely lean body mass and the weight gained back is likely belly fat.

One more thing to worry about, as if we are short of things to worry about  :D
Infected Mid June, 2019
Acute syndrome late June, started Biktarvy
3 weeks post infection (1 week on ART): VL: 330k, CD4 400 (33%), CD8 460, CD4/CD8 ratio: 0.9
5 weeks pi: VL: 300, CD4: 500 (30%), CD8: 690, ratio: 0.7
8 weeks: VL: 30,  CD4: 590 (28%), CD8: 920, ratio: 0.6
12 weeks: VL <30, CD4: 750 (37%), CD8: 700, ratio 1.1
20 weeks: VL<30, CD4 550 (dropped from 750 from 2 months ago, 38%), CD8 450, Ratio 1.2, elevated liver enzymes

Offline harleymc

  • Member
  • Posts: 1,361
Re: weight gain on Biktarvy
« Reply #5 on: October 31, 2019, 08:38:41 pm »
"One more thing to worry about, as if we are short of things to worry about"

Don't worry, live in the moment with mindfulness

Offline jcelvis

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  • Posts: 81
Re: weight gain on Biktarvy
« Reply #6 on: December 12, 2019, 02:51:23 pm »
A lot of this is anecdotal, but  i have been complaining about the new drugs (genvoya and biktarvy) to my doctors for years, but he will not switch me.

I noticed substantial weight gain after I switched to genvoya about 10%- 15% weight increase. I continually asked my doctor if this was a side effect, but back in 2016 there were no studies to confirm this.  I was switched to biktarvy because of this concern. I am still experiencing the same issues I had with genvoya

The weight gain for me has been a stress and it has caused obsessions in me. I constantly weigh myself, and binge diet. I get at least 60 min of activity a day, and I find it extremely difficult to maintain my weight.

 I figured out that i can eat about 1700-2100 calories a day to maintain my weight (currently I'm 6ft 178lbs). Typical for my age/height should be able to consume at least 2400 (with a normal activity level), and at my level, which is on the active side,  I should be able to consume 2800 a day.


On atripla i weighed about 158 (started 2009), Switched to  stribild in 2014 and maintained around a weight around 165.

When i switched to genvoya at one point my weight shot up to 189lbs. Again I am active. I go to the gym and play sports. I was not trying increase my weight so 24lbs is a lot.
Change the way you view the world, and the world around you changes.

Offline gorka

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  • Posts: 79
Re: weight gain on Biktarvy
« Reply #7 on: January 02, 2020, 10:23:55 am »
i gained 50lbs since starting biktarvy in 2016(i was part of the study) and most of it is in my belly.  I am switching to Dovato as soon as I finish last 3 month supply of the drug.  Latest studies suggest that TAF also contributes to weight gain.  I was newly infected so no acute infection and was already little bit overweight when I became poz. 

Offline harleymc

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  • Posts: 1,361
Re: weight gain on Biktarvy
« Reply #8 on: January 03, 2020, 02:19:10 pm »
I've packed on 5 kg in 8 months, just can't shift it, next time I visit my doc I'll ask for a different script.  Oh and my cholesterol was literally off the scale, unmeasurable.

Offline venom_X

  • Member
  • Posts: 28
Re: weight gain on Biktarvy
« Reply #9 on: January 04, 2020, 02:26:27 am »
I've packed on 5 kg in 8 months, just can't shift it, next time I visit my doc I'll ask for a different script.  Oh and my cholesterol was literally off the scale, unmeasurable.

Do you mean you cholesterol was higher than measurement range limits?

My weight gain continued even after I became very mindful on my diet (think salads every day) and increased exercises. My LDL is also off the chart.

Will Dovato be better in this case?

Infected Mid June, 2019
Acute syndrome late June, started Biktarvy
3 weeks post infection (1 week on ART): VL: 330k, CD4 400 (33%), CD8 460, CD4/CD8 ratio: 0.9
5 weeks pi: VL: 300, CD4: 500 (30%), CD8: 690, ratio: 0.7
8 weeks: VL: 30,  CD4: 590 (28%), CD8: 920, ratio: 0.6
12 weeks: VL <30, CD4: 750 (37%), CD8: 700, ratio 1.1
20 weeks: VL<30, CD4 550 (dropped from 750 from 2 months ago, 38%), CD8 450, Ratio 1.2, elevated liver enzymes

Offline J.R.E.

  • Member
  • Posts: 7,652
  • Joined forum Dec/2003 Living positive, since 1985.
Re: weight gain on Biktarvy
« Reply #10 on: January 04, 2020, 03:03:33 pm »
After the recent batch of research came out on the DTG's impact on weight gain, I myself experienced it first hand and want to check if anyone else has noticed similar.

On Biktarvy now for 4 months now and I gained about 10 lbs. I could literally feel that a beer belly is forming (which I never had before in my life). The LDL and trig levels stay about the same.


I know I posted this before in another thread, Started Biktarvy on July 15 th 2019, and gained 10-12 pounds as well.

Will be seeing the ID doctor in another week or so, and will tell her I want to go back to Viramune and Epzicom. Was on that, for 14 years, without all that much weight gain. All in the belly !

Ray
Current Meds ; Viramune / Epzicom , 20 mg of Atorvastatin, 25 mg of Hydrochlorothiazide.
Amlodipine Besolate 5mg-- Updated 1/14/20

Diagnosed positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 As of 12/16/19,  Viral load remains <40

CD 4 @422 /  CD4 % @ 16 %

  
 68 years young.

Offline harleymc

  • Member
  • Posts: 1,361
Re: weight gain on Biktarvy
« Reply #11 on: January 04, 2020, 10:02:38 pm »
Literally to high to read

Offline gorka

  • Member
  • Posts: 79
Re: weight gain on Biktarvy
« Reply #12 on: January 05, 2020, 02:31:15 am »
Do you mean you cholesterol was higher than measurement range limits?

My weight gain continued even after I became very mindful on my diet (think salads every day) and increased exercises. My LDL is also off the chart.

Will Dovato be better in this case?

I hope so since it does not have TAF.  Even though dolutegravir also contributes to weight gain its better just one vs two meds doing it I guess

 


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