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Author Topic: Suppression of Zika Virus Infection by HIV Drug Rilpivirine  (Read 661 times)

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Online Jim Allen

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Suppression of Zika Virus Infection by HIV Drug Rilpivirine
« on: November 02, 2019, 04:49:15 am »
Interesting and hopeful news for the possible future treatment of the Zika virus.

https://www.sciencedaily.com/releases/2019/10/191030132700.htm

In short:

Quote
In cell and animal models, they show that the drug, called rilpivirine, stops Zika virus by targeting enzymes that both HIV and Zika virus depend on for their replicatio

Dr. Gordon's team carried out experiments in mice, in which animals were infected with Zika virus through their footpads, similar to the way a person becomes infected through a mosquito bite. Mice that become infected with Zika virus normally become very sick within about a week and eventually die. "We found, however, that when treated with rilpivirine, the animals survived," Dr. Gordon said. "Our conclusion is that rilpivirine disrupted the virus's usual course of infection."

Rilpivirine is one of several non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs that have been developed for the treatment of HIV infection. Experiments in which the Temple researchers tested two other NNRTIs in Zika-infected cells revealed similar effects on viral replication, with the drugs specifically inhibiting NS5 activity.

"We now have a clear path forward," Dr. Khalili said. "We have a starting point from which we can find ways to make these drugs even more potent and more effective against flaviviruses." The researchers plan to soon step up their studies to develop ways to improve the effectiveness of NNRTIs in blocking infection with Zika virus and other flaviviruses.

Epidemics involving flavivirus infections, particularly HIV, Zika, dengue, and hepatitis C, frequently overlap geographically and temporally. "The potential applications of this work are huge," Dr. Klein added.

Study: https://www.sciencedirect.com/science/article/abs/pii/S1525001619304605
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Offline Expat1

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Re: Suppression of Zika Virus Infection by HIV Drug Rilpivirine
« Reply #1 on: November 02, 2019, 11:41:59 am »
Glad to know, if any mice around here get infected with Zika, I can give them my odefsey.   (LOL) ;)

Online Jim Allen

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Re: Suppression of Zika Virus Infection by HIV Drug Rilpivirine
« Reply #2 on: November 02, 2019, 12:10:12 pm »
 ;D

Yeah, we will have to wait and see how they are going to get this into Human trials if ever.
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