Welcome, Guest. Please login or register.
April 07, 2020, 01:43:11 pm

Login with username, password and session length


Members
Stats
  • Total Posts: 753358
  • Total Topics: 63523
  • Online Today: 330
  • Online Ever: 4912
  • (November 13, 2019, 02:56:14 am)
Users Online
Users: 0
Guests: 72
Total: 72

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Switching from Biktarvy to Dovato...?  (Read 1173 times)

0 Members and 1 Guest are viewing this topic.

Offline MrAlwaysAnxious

  • Member
  • Posts: 12
  • I survived, and the world deserves to know that.
Switching from Biktarvy to Dovato...?
« on: October 10, 2019, 10:30:38 pm »
Hello,

I hope everyone has been doing well. It has been about 7 months since I was diagnosed during acute seroconversion, and am undetectable.

I switched from Symtuza to Biktarvy about three or four months ago. I have been doing better on it than Symtuza, and haven't really had an issues with it. My doctor and I talked about switching to Dovato, and I was wondering if anyone had any experience with Dovato?

I am hoping it will have less side effects, but am also a little worried since I know very little about this drug.
Dx: 3/15/19
CD4: 349/33% on 3/20/19
VL: 9,820,000 on 3/20/19
Rx: Started Symtuza on 3/15/19
CD4: 771/39% on 4/16/19
VL: 484 on 4/16/19

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 15,184
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Switching from Biktarvy to Dovato...?
« Reply #1 on: October 11, 2019, 12:53:13 am »
Hiya

Dovato contains Dolutegravir + Lamivudine. It's two of the drugs in my regime.
Dolutegravir is okay, I love it but it's not everyone's cup of tea.

Since you are not having issues with the Biktarvy and have only been on it for a very short time was it the Doctor initiate the idea of switching again?

Jim
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline fabio

  • Member
  • Posts: 445
Re: Switching from Biktarvy to Dovato...?
« Reply #2 on: October 11, 2019, 06:56:06 am »
What issues did you have with symtuza btw?
I will be getting symtuza,since its just one pill instead of the 2 i take. In my case it doesnt really do anything different.

Offline FarmBoy

  • Member
  • Posts: 13
Re: Switching from Biktarvy to Dovato...?
« Reply #3 on: October 11, 2019, 11:07:19 am »
Hi Mr Anxious

Glad to hear you are undetectable and doing well.

I switched to Dovato on July 1 after I used up my Triumeq which I had started on 3 years ago. I had asked my Dr. at my May 27th appointment if I could switch and he agreed to the change.   As Jim stated, Dovato is a 2 drug version of Triumeq I already was taking but without the abacavir.  There has been no difference nor issues for me in switching and I like the idea of taking fewer drugs for the same result.

One reason your doctor may be suggesting the change now is that Dovato (which wasn't widely available yet when you were diagnosed) is the first first-line, single-pill treatment option where the cost is cheaper than what was previously available.  Dropping the abacavir reduced the price $750/month over Triumeq but also, its one less drug going into my body every day with no change in outcome.

It appears that both of these new combo pills are highly effective, have minimal side effects, are well-tolerated and neither has a food requirement.

The difference then is the cost.  In the US, Bictarvy is listed at $3250/month and Dovato is listed at $2295/mo. or $11,500 less per year for the same outcome of suppressing the virus.  So I feel that what any good doctor in the US should do is to consider the cost of treatment if all other factors are the same. (Dovato also is 1 less drug entering your body long-term).  Outrageous drug prices in the US are a major contributor to the health insurance crisis in the US.

Gilead got a head start in approval and promoting Bictarvy.  They know that most doctors won't switch patients.  Also, I notice that they heavily advertise Bictarvy on TV in the evening in our market where Viiv doesn't spend the money on  advertising Dovato on TV - so I assume that they also heavily promote their drug to the doctors to lock in their high price.

Both companies offer co-pay assistance for private insurance:
Bictarvy - $7200/year with no monthly limit.
Dovato - $6250/year with no monthly limit.

Since my max out of pocket on my company provided insurance is $6000/year, I don't pay any cost out of pocket for my medicine either way.  So I see it as benefiting me by taking less medicine and saving my insurance almost $10,000/yr so hopefully premiums won't rise quite as fast.

Either way, it's up to you and your doctor to determine what's best.  As for me, I've had no issues switching to Dovato.
7/25/16 - Infected
8/4/16 - Sero-conversion started (flu, then fever, fatigue most of August)
8/29/16 - hospitalized O.N. for dehydration; tested
9/1/16 - Dx'd (confirmed WB 9/2)
9/6/16 - CD4 1395 (15%); VL 275,904; genotyped
10/5/16 - CD4 800 (27%) Started on Triumeq
11/2/16 - CD4 699 (26%); VL <20
1/11/17 - no CD4; VL <20
5/17/17 - CD4 742 (22%); VL <20
11/15/17 - CD4 745 (33%); VL <20
5/16/18 - no CD4; VL <20
11/28/18 - no CD4; VL <20
05/29/19 - no CD4; VL <20
07/01/19 - switched to Dovato
11/20/19 - CD4 835 (32%); VL <20

Offline MrAlwaysAnxious

  • Member
  • Posts: 12
  • I survived, and the world deserves to know that.
Re: Switching from Biktarvy to Dovato...?
« Reply #4 on: October 17, 2019, 03:58:43 pm »
What issues did you have with symtuza btw?
I will be getting symtuza,since its just one pill instead of the 2 i take. In my case it doesnt really do anything different.

Hi Fabio,

The only issues I was having while on Symtuza were higher-than-usual liver panel readings, gastrointestinal issues, and nightmares. I will say, I was taking this medication during an acute infection (seroconversion).

Hi Mr Anxious

Glad to hear you are undetectable and doing well.

I switched to Dovato on July 1 after I used up my Triumeq which I had started on 3 years ago. I had asked my Dr. at my May 27th appointment if I could switch and he agreed to the change.   As Jim stated, Dovato is a 2 drug version of Triumeq I already was taking but without the abacavir.  There has been no difference nor issues for me in switching and I like the idea of taking fewer drugs for the same result.

One reason your doctor may be suggesting the change now is that Dovato (which wasn't widely available yet when you were diagnosed) is the first first-line, single-pill treatment option where the cost is cheaper than what was previously available.  Dropping the abacavir reduced the price $750/month over Triumeq but also, its one less drug going into my body every day with no change in outcome.

It appears that both of these new combo pills are highly effective, have minimal side effects, are well-tolerated and neither has a food requirement.

The difference then is the cost.  In the US, Bictarvy is listed at $3250/month and Dovato is listed at $2295/mo. or $11,500 less per year for the same outcome of suppressing the virus.  So I feel that what any good doctor in the US should do is to consider the cost of treatment if all other factors are the same. (Dovato also is 1 less drug entering your body long-term).  Outrageous drug prices in the US are a major contributor to the health insurance crisis in the US.

Gilead got a head start in approval and promoting Bictarvy.  They know that most doctors won't switch patients.  Also, I notice that they heavily advertise Bictarvy on TV in the evening in our market where Viiv doesn't spend the money on  advertising Dovato on TV - so I assume that they also heavily promote their drug to the doctors to lock in their high price.

Both companies offer co-pay assistance for private insurance:
Bictarvy - $7200/year with no monthly limit.
Dovato - $6250/year with no monthly limit.

Since my max out of pocket on my company provided insurance is $6000/year, I don't pay any cost out of pocket for my medicine either way.  So I see it as benefiting me by taking less medicine and saving my insurance almost $10,000/yr so hopefully premiums won't rise quite as fast.

Either way, it's up to you and your doctor to determine what's best.  As for me, I've had no issues switching to Dovato.

Thank you for sharing your experience with Dovato! I recently got it and found out my insurance covers the entire cost of the drug (it did not with Biktarvy and had to use the copay card). I feel a little better after just taking it for two days. I'll report back after about a month and after getting another VL test done!
Dx: 3/15/19
CD4: 349/33% on 3/20/19
VL: 9,820,000 on 3/20/19
Rx: Started Symtuza on 3/15/19
CD4: 771/39% on 4/16/19
VL: 484 on 4/16/19

 


Terms of Membership for these forums
 

© 2020 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.