Welcome, Guest. Please login or register.
August 17, 2019, 07:11:11 pm

Login with username, password and session length


Members
Stats
  • Total Posts: 746830
  • Total Topics: 62530
  • Online Today: 303
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 am)
Users Online
Users: 1
Guests: 276
Total: 277

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: QUATUOR  (Read 304 times)

0 Members and 1 Guest are viewing this topic.

Offline bufguy

  • Member
  • Posts: 212
QUATUOR
« on: August 09, 2019, 01:55:35 pm »
 I was wondering what people's thoughts are on QUATUOR study which studied HIV positive patients who took their meds 4 days per week and refrained the other 3. The study showed they were for the most part maintain an undetectable viral load. This seems to mimic a study about ten years ago, FOTO, Five days On, Two days Off which showed that patients on Atripla maintained suppression by taking their meds for five days and refraining for two.
A decreased regimen could have a profound effect on the cost of meds for people...20-30% savings plus a lessened drug burden on the body.
What are people's thoughts? Has anyone tried this reduced regimen?
5/29/08 confirmed HIV+
6/23/08 Vl 47500  CD4 511/29% CD8 .60
start atripla
8/1/08 Vl 130  CD4 667/31% CD8 .70
9/18/08 Vl un  CD4 not tested
12/19/08 Vl un CD4 723/32% CD8 .80
4/3/09 Vl un CD4 615/36% CD8  .98
8/7/09 vl un CD4 689/35% CD8 .9
12/11/09 vl un CD4 712/38% CD8 .89
4/9/10 vl un CD4 796/39% CD8 1.0
8/20/10 vl un CD4 787/38% CD8 1.0
4/6/10 vl un CD4 865/35% CD8 .9
8/16/10 vl un CD4 924/37% CD8 1.0
12/23/10 vl un CD4 1006/35% CD8 .9
5/2/10 vl un CD4 1040/39% CD8 .9
8/7/13 vl un CD4 840/39% CD8 .
11/29/18 vl un CD4 1080/39% CD8  .86

Offline Ptrk3

  • Global Moderator
  • Member
  • Posts: 2,660
Re: QUATUOR
« Reply #1 on: August 09, 2019, 02:35:28 pm »
I don't think it's a good idea to start a four-day per week regimen (on Atripla or any other single-pill) until all phases of the study are completed (including withstanding the scientific process/method and required peer review) and the regimen is adopted throughout the healthcare community.

It is my conviction that HIV-positive individuals should work closely with his or her healthcare provider to maintain health and well being, according to the current scientific and medical protocol for the specific individual (individual outliers may always exist who require a specific antiretroviral regimen:  no one should experiment on his or her own and risk treatment failure of an antiretroviral class).

That written, yes, it would be a very good thing, indeed, if the study pans out.  Let's  hope it does!
« Last Edit: August 13, 2019, 02:56:50 pm by Ptrk3 »
HIV 101 - Basics
HIV 101
You can read more about Transmission and Risks here:
HIV Transmission and Risks
You can read more about Testing here:
HIV Testing
You can read more about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read more about HIV prevention here:
HIV prevention
You can read more about PEP and PrEP here
PEP and PrEP

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 12,767
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: QUATUOR
« Reply #2 on: August 09, 2019, 02:44:09 pm »
Hiya

We have a thread on this study. https://forums.poz.com/index.php?topic=72799.0

4 days a week would make no direct difference to me and, the study so far is too early days for my comfort level given resistance risks dropping two/three days of meds is no pill burden reduction if you are the unlucky sod who ends up resistant, although who knows what the future brings in the meantime I will stay put on 7 days

Jim

i-Base report urges caution over French study only taking ART 4 days a week
@IAS_conference  see: link: http://i-base.info/htb/36517

For days on, three days off is NOT as effective as daily ART: French study results need to be interpreted with caution
« Last Edit: August 09, 2019, 02:50:36 pm by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline virgo313

  • Member
  • Posts: 184
Re: QUATUOR
« Reply #3 on: August 10, 2019, 01:10:07 am »
I will take mine daily until a day when Dr advise otherwise.
RVD Nov 2015. VL --> Log 5.32 HAART on 23/11/15
TDF+FTC+EFV / Chemo KS - 25/11/15 - 20/01/16.
CD4 - 4 (3/11/15) / VL - 225,000   ~ CD4 - 65 (7/03/16) / VL - UD
CD4 - 153 (8/09/16) / VL - UD (20) / CD4% -6%   ~   CD4 - 215 (11/03/17) / VL - No Result / CD4% -8%
CD4 - No Result (10/04/17) / VL - UD (20)   ~   CD4 - 455 (11/05/18) / VL - UD / CD4% -14%
CD4 + CD4% (18/10/18) - Dr not going to  do this anymore / VL - To test only yearly. This Sucks..!
CD4 - 472 (10/04/19) / VL - UD / CD4% - 42%

Offline bufguy

  • Member
  • Posts: 212
Re: QUATUOR
« Reply #4 on: August 11, 2019, 07:10:02 pm »
Thank You for the link.....I reread the article on the FOTO study from 2009. The study was pretty convincing as to 5 days on 2 days off. The only comment was the small sample size. The results though are pretty extraordinary and it begs the question why wasn't there more in depth larger sample study? And know we see another study that backs it up. Not to sound like a conspiracy theorist but it certainly wouldn"t be in Gilead"s best interest to show that people with HIV could thrive with 30% less meds....Just sayin"
5/29/08 confirmed HIV+
6/23/08 Vl 47500  CD4 511/29% CD8 .60
start atripla
8/1/08 Vl 130  CD4 667/31% CD8 .70
9/18/08 Vl un  CD4 not tested
12/19/08 Vl un CD4 723/32% CD8 .80
4/3/09 Vl un CD4 615/36% CD8  .98
8/7/09 vl un CD4 689/35% CD8 .9
12/11/09 vl un CD4 712/38% CD8 .89
4/9/10 vl un CD4 796/39% CD8 1.0
8/20/10 vl un CD4 787/38% CD8 1.0
4/6/10 vl un CD4 865/35% CD8 .9
8/16/10 vl un CD4 924/37% CD8 1.0
12/23/10 vl un CD4 1006/35% CD8 .9
5/2/10 vl un CD4 1040/39% CD8 .9
8/7/13 vl un CD4 840/39% CD8 .
11/29/18 vl un CD4 1080/39% CD8  .86

Offline wardp

  • Member
  • Posts: 130
Re: QUATUOR
« Reply #5 on: August 13, 2019, 01:30:05 pm »
.every individuals HIV vl CD count is different not one size fits all. 4 days a week might make you less compliant also.
Diagnosed 20,July 2017. Cd4 289, 21% vld .3,462 Started atripla 4 Aug 2017 5oct 2017 cd4 384 21%, vl ud less than 20. Switch to complera 4 Nov 2017 switched to stribild 15 the Nov. Switched to truvada efavirence 200mgx2 14 Dec 2017, 2 Feb 2018, us cd4  466, 25%  CD 8 ,595, 32%..1 may 2018
switched  to instgra truvada.7th june switched to truvada  nevirapine stavudine. .21 june switched to truvada nevirapine. X 2 a day...9 aug 2018 ud. 2n Nov 2018 CD 4. 455..22.70% 13th Nov switched  to lamivir and nevirapine  due to kidney issues...jan 10,2019 UD..may 13 2019 ud  cd4 482 28%

 


Terms of Membership for these forums
 

© 2019 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.