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Author Topic: Possible unique HIV clearance case  (Read 668 times)

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Online Jim Allen

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Possible unique HIV clearance case
« on: June 11, 2019, 05:24:00 am »
Interesting/nice morning read about this possible case of HIV clearance, the circumstances are unique although, I would not call anything about this case good luck.
 
Full write-up from Aidsmap http://www.aidsmap.com/page/3511496/
In short:

Quote
Researchers in Sydney, Australia have identified a patient who appears to have spontaneously cleared his own HIV infection without any medication, many years after he was first infected.

The researchers now feel they have enough evidence so say that C135 represents “a probable case of clearance of HIV infection”, after repeated polymerase chain reaction (PCR) testing of lymphocytes (T-cells) taken from the blood, and from gut and lymph node tissue.



http://viruseradication.com/journal-details/Possible_clearance_of_transfusion-acquired_Nef_and_LTR-deleted_attenuated_HIV-1_infection_by_an_elite_controller_with_CCR5_%CE%9432_heterozygous_and_HLA-B57_genotype/
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Offline Genomity

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Re: Possible unique HIV clearance case
« Reply #1 on: June 11, 2019, 07:51:55 am »
Great, so encouraging!

Offline leatherman

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Re: Possible unique HIV clearance case
« Reply #2 on: June 11, 2019, 08:38:42 am »
I would not call anything about this case good luck.
if C135 had really been lucky he would have had no CCR5.  ;)
it is hard to call it "good luck" to have been in a car accident and hurt so bad to need a blood transfusion, then to have been infected with HIV by that transfusion even if that HIV was cleared 20 years later.

Quote
However “Subject C135” appears to have a unique combination of fortunate circumstances that only serve to show how difficult it is to eliminate HIV infection once it is established. The researchers warn that we do not yet know if the same characteristics could be re-created in other people with HIV by artificial means such as genetic engineering and vaccines.
. . .
In addition, however, he had genetic factors that ensured this early immune response was particularly fast and efficient, which may have ensured that his already slow-acting HIV never had the time to develop resistance to the immune response. Instead, that response did what it does with the majority of viruses that are not HIV - it cleared it.
personally I don't see these one-off cases as particularly encouraging as replicating these outcomes is next to impossible.
leatherman (aka mIkIE)


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Online Jim Allen

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Re: Possible unique HIV clearance case
« Reply #3 on: June 11, 2019, 11:05:30 am »
Quote
if C135 had really been lucky he would have had no CCR5.  ;)
it is hard to call it "good luck" to have been in a car accident and hurt so bad to need a blood transfusion, then to have been infected with HIV by that transfusion even if that HIV was cleared 20 years later.

Yup. I think the "Good luck" from Aidsmap was prehaps poorly chosen
HIV 101 - Everything you need to know
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Transmission and Risks:
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PEP and PrEP

 


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