Welcome, Guest. Please login or register.
April 19, 2019, 08:46:12 am

Login with username, password and session length


Members
Stats
  • Total Posts: 743245
  • Total Topics: 61990
  • Online Today: 176
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 am)
Users Online
Users: 4
Guests: 125
Total: 129

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: HIV-1 envelope changes - Another Way HIV Hides From Vaccines  (Read 152 times)

0 Members and 1 Guest are viewing this topic.

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 11,476
  • Twitter @JimAllenDublin
    • HIV Lessons
Interesting, not surprising though. HIV tends to always have an additional trick up its sleeve.
   
https://scitechdaily.com/scientists-reveal-another-way-hiv-hides-from-vaccines/
By BILL HATHAWAY, YALE UNIVERSITY APRIL 12, 2019

Quote
A Yale-led team has discovered yet another molecular trick HIV uses to survive immune system attacks, a finding that may influence efforts to develop an effective vaccine against HIV/AIDS.

The virus forms specifically shaped structures called trimers on its surface, which are designed to attach to and infect cells and produce more HIV. To escape the immune system, the trimer can change shapes over time into three separate conformations. Vaccines now under development target one form of those structures in order to spur an immune system response. However, the new study published April 10 in the journal Nature shows that the HIV may escape immune system detection by hiding in yet another trimer conformation, called State 1.

Patients fight HIV by developing broadly neutralizing antibodies, and most of these antibodies recognize the State 1 conformation, the authors report.

“If these antibodies can bind to a trimer in State 1, any immunogens in a vaccine should recognize this conformation,” said Walther Mothes, professor of microbial pathogenesis and co-senior author of the paper. “Surprisingly, however, current immunogens recognize the State 2 conformation and apparently elicit State 2-specific antibodies.”

Abstract:

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET : https://www.ncbi.nlm.nih.gov/pubmed/30971821
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

 


Terms of Membership for these forums
 

© 2019 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.