Welcome, Guest. Please login or register.
March 19, 2019, 04:23:23 am

Login with username, password and session length


Members
Stats
  • Total Posts: 742066
  • Total Topics: 61797
  • Online Today: 101
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 am)
Users Online
Users: 2
Guests: 77
Total: 79

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Monthly Injectable Treats HIV as Well as Daily Meds  (Read 501 times)

0 Members and 1 Guest are viewing this topic.

Offline Ptrk3

  • Global Moderator
  • Member
  • Posts: 2,592
Monthly Injectable Treats HIV as Well as Daily Meds
« on: March 08, 2019, 10:07:55 pm »
From the March 8, 2019, edition of POZ online magazine:

(Lede paragraph)  Treating HIV with monthly combination injections of long-acting formulations of ViiV Healthcare’s cabotegravir and Janssen’s Edurant (rilpivirine) suppresses the virus as effectively as a standard daily oral antiretroviral (ARV) regimen. Given the success of the experimental regimen in a pair of advanced trials, the long-acting combination of cabotegravir and Edurant is poised to achieve approval from heath regulators, including the Food and Drug Administration (FDA)....
This would mark the first time an approved regimen does not require taking daily oral medications.

Link to story:

https://www.poz.com/article/monthly-injectable-treats-hiv-daily-meds

Nota Bene: The FDA's approval decision could come early 2020.  If approved, the injection would need to be given in a clinic and would not be self-administered.
HIV 101 - Basics
HIV 101
You can read more about Transmission and Risks here:
HIV Transmission and Risks
You can read more about Testing here:
HIV Testing
You can read more about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read more about HIV prevention here:
HIV prevention
You can read more about PEP and PrEP here
PEP and PrEP

Offline Mightysure

  • Member
  • Posts: 406
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #1 on: March 08, 2019, 10:52:33 pm »
Selfishly, I want the approval delayed so I can keep getting it for free, but I think more people will come around to it once it hits the market.
75% of us experienced injections site pain, yet 97% of us prefer this over daily pills. Once a month vs 30 x per month. No bottles with your name and drug names on them. Meds sit in your hip.

This is gonna be a game changer.

Offline JimDublin

  • Administrator
  • Member
  • Posts: 11,123
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #2 on: March 09, 2019, 02:01:23 am »
With all new combo's & treatments it's great to see more options developing, as people will have more choices and, this monthly injectable will surly suit some people.

As i've said before I think there are draw backs like having to preform monthly clinic visits, that will be a barrier for some people towards this Injectable but who knows maybe the next generation of this in the future could be 3 or 6 months. 

Jim
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline BKKKevin

  • Member
  • Posts: 129
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #3 on: March 09, 2019, 07:48:29 am »
...

Offline Mightysure

  • Member
  • Posts: 406
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #4 on: March 09, 2019, 09:03:56 am »
With all new combo's & treatments it's great to see more options developing, as people will have more choices and, this monthly injectable will surly suit some people.

As i've said before I think there are draw backs like having to preform monthly clinic visits, that will be a barrier for some people towards this Injectable but who knows maybe the next generation of this in the future could be 3 or 6 months. 

Jim

They are working on having pharmacists do it and also arrange for home visits.
Im hoping that they're able to get it approved for bi monthly injections. The data so far looks good for those getting injections e every other month.

I think there should be more tailored treatments. And if someone can go 3 months, that should be available to them.

Offline JimDublin

  • Administrator
  • Member
  • Posts: 11,123
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #5 on: March 09, 2019, 09:21:55 am »
Pharmacy option if that happens it would certainly open it up to more people, and maybe one day once it reaches 3-6 months and self injection it would open up to an even wider market.

In the meantime we will have to wait, see how things go.

Jim 
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline leatherman

  • Member
  • Posts: 7,511
  • Google and HIV meds are Your Friends
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #6 on: March 09, 2019, 09:28:34 am »
And if someone can go 3 months, that should be available to them.
what's a "tailored treatment"? You could pay for "therapeutic drug monitoring" to have monthly blood work gone to determine the best dosage for you; but that's incredibly expensive for a small change from the recommended dosage.

Options aren't just "made available" (unless you're dying of leukemia and you might want to try stem cell/bone marrow transplant). Ethically, it will require several years worth of trials to determine if anyone can remain virally suppressed for 3 months, who might fit that same profile and who doesn't, what side effects there might be, and what restrictions/limitations might need to be considered.
leatherman (aka mIkIE)

There's no rain, there's no storm, though the blue sky makes you wonder
Don't you fear what will come will come
And right now we're in the sun
Sure enough, seasons change
But don't let today get lost 'cause today the sun's on us
Today the sun's on us
- Sophie Ellis-Bextor

chart from 1992-2017
Tivicay/Prezcobix

Offline Mightysure

  • Member
  • Posts: 406
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #7 on: March 11, 2019, 06:07:50 pm »
what's a "tailored treatment"? You could pay for "therapeutic drug monitoring" to have monthly blood work gone to determine the best dosage for you; but that's incredibly expensive for a small change from the recommended dosage.

Options aren't just "made available" (unless you're dying of leukemia and you might want to try stem cell/bone marrow transplant). Ethically, it will require several years worth of trials to determine if anyone can remain virally suppressed for 3 months, who might fit that same profile and who doesn't, what side effects there might be, and what restrictions/limitations might need to be considered.

What do you mean monthly therapeutic blood monitoring? I didnt mean everyone goes to a compounding pharmacy, although they should be available for those who can afford it.

What I mean is there should be more dosage strengths. Not everyone metabolizes 50 mg of Tivicay the same way. Some may get by on 25 mg, or what have you.

I dont think you need blood monitoring to see that based on someone's weight, height, age, and other health factors that they may be able to survive on less than the standard dose.

Offline leatherman

  • Member
  • Posts: 7,511
  • Google and HIV meds are Your Friends
Re: Monthly Injectable Treats HIV as Well as Daily Meds
« Reply #8 on: March 12, 2019, 03:45:22 pm »
I dont think you need blood monitoring to see that based on someone's weight, height, age, and other health factors that they may be able to survive on less than the standard dose.
while weight, height age, etc. are factors influencing metabolism rate; however metabolism rate is more about digestive absorption rate, the rate of distribution, and rate of elimination; but I get what you're talking about.

I've always had a really fast metabolism. Maybe it's from the amount of Coke I drink (over 2-liters a day) or maybe it's why I can drink that much a day and still weight 145 lbs. Whatever the reason (I'm guessing genetic), meds of any type have always been hard on me. For most meds I take about half the dosage and have had successful treatment for whatever ails me. Clearly there's a dosage that is smaller than the dosage in the pills that works for me but without therapeutic drug monitoring there is no way to know the exact dosage is, so I don't not suggest or propose anyone not taking 100% of their meds as prescribed by their doctor.
(however, if you don't all of your meds and your treatment is still successful, well, I understand that ;) )
leatherman (aka mIkIE)

There's no rain, there's no storm, though the blue sky makes you wonder
Don't you fear what will come will come
And right now we're in the sun
Sure enough, seasons change
But don't let today get lost 'cause today the sun's on us
Today the sun's on us
- Sophie Ellis-Bextor

chart from 1992-2017
Tivicay/Prezcobix

 


Terms of Membership for these forums
 

© 2019 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.