Welcome, Guest. Please login or register.
February 20, 2019, 09:07:37 am

Login with username, password and session length


Members
Stats
  • Total Posts: 741054
  • Total Topics: 61647
  • Online Today: 269
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 am)
Users Online
Users: 3
Guests: 104
Total: 107

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Differences in Viral Genes May Affect Size of HIV Reservoir  (Read 179 times)

0 Members and 1 Guest are viewing this topic.

Offline JimDublin

  • Administrator
  • Member
  • Posts: 10,817
  • Twitter @JimAllenDublin
    • HIV Lessons
Differences in Viral Genes May Affect Size of HIV Reservoir
« on: January 19, 2019, 05:22:50 am »
Interesting thought/info, although not directly helpful.
ill will say it's a very tiny sample size to actually conclude anything.

Differences in Viral Genes May Affect Size of HIV Reservoir
https://www.poz.com/article/differences-viral-genes-may-affect-size-hiv-reservoir

Quote
Publishing their findings in the Journal of Virology, researchers analyzed viral samples and data about the HIV reservoir among 30 Canadians who had recently contracted the virus. The scientists quantified the size of the participants’ reservoirs according to the levels of viral DNA integrated into human cells (known as proviral DNA) as well as levels of virus in CD4 cells that was replication competent, meaning it had the capacity to produce viable new copies of HIV.

Twenty-five of the participants had clade B of HIV and five had a different clade of the virus. A previous study had found that people with clade B tended to have larger viral reservoirs than those with clade A or D. The researchers theorized at the time that such differences were driven in part by the fact that clade B viruses have a more functional version of the nefgene.

After a year of antiretroviral treatment, the participants of the new study who had clade B virus did wind up with smaller reservoirs than the other study members. And those with non–clade B virus did have less functional copies of nef. Furthermore, the less active the gene, the smaller the reservoir. Additionally, among those with clade B, having a more functional copy of nefwas tied to having a larger reservoir.

The characteristics of nef did not fully explain differences in reservoir size among the participants, suggesting that more research is needed to help investigators better comprehend the multiple factors, including viral genes and proteins, that affect variations in reservoir size.
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

 


Terms of Membership for these forums
 

© 2019 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.