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Author Topic: HIV treatment outcomes continue to get better, says large analysis  (Read 756 times)

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Offline JimDublin

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Well that's good and, hopefully things continue to improve still in the future

Jim

Published: Aidsmap.com 27 December 2018
In full: http://www.aidsmap.com/HIV-treatment-outcomes-continue-to-get-better-says-large-analysis/page/3398696/

Quote
The efficacy of first-line antiretroviral therapy (ART) continues to improve, according to an analysis of outcomes in 78,000 people in 181 studies, published in AIDS by Professor Andrew Carr of St Vincent's Hospital in Sydney and colleagues. Over three-quarters of people who started treatment between 2011 and 2015 were still on their first regimen and had an undetectable viral load three years later.

Outcomes in 2011-2015 were significantly better than those recorded in people starting therapy between 2006 and 2010, which in turn were an improvement on results seen in people who started treatment between 2001 and 2005 and between 1994 and 2000. Moreover, there was a steady and sustained fall in the proportion of individuals who stopped their first line regimen because of side-effects or due to personal choice. However, the proportion of people stopping because of virological failure flatlined at approximately 5%.

The study:
PMID: 30475265 DOI: https://doi.org/10.1097/QAD.0000000000002077
Success and failure of initial antiretroviral therapy in adults: an updated systematic review of 77,999 subjects from 1994 to 2017.
Carr A1, Richardson R1, Liu Z2.
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Offline tryingtostay

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Re: HIV treatment outcomes continue to get better, says large analysis
« Reply #1 on: January 05, 2019, 07:07:04 pm »
My VL was so low they couldn't do a resistance test but I went on Complera/Odefsey.  I often wonder if the meds are doing anything

Offline JimDublin

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Re: HIV treatment outcomes continue to get better, says large analysis
« Reply #2 on: January 06, 2019, 12:07:35 am »
Not quite sure i see the connection with this article. 

Anyhow you started out with low VL's, and than started treatment in 2016.
Nowadays regardless of the numbers treatment is recommend, since starting treatment no blips right? Then there is no logical reason to think they are not working and even EC have benefits from treatment. https://forums.poz.com/index.php?topic=68419.0

Jim

« Last Edit: January 06, 2019, 08:52:34 am by JimDublin »
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Offline daveR

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Re: HIV treatment outcomes continue to get better, says large analysis
« Reply #3 on: January 06, 2019, 04:02:24 am »
They seem to be happy that people are still undetectable on their first regime after 3 years, I would have expected that now a days as a normal occurrence. I have read plenty of people posting on this forum who have been on the same regime for much longer than that with out problems.

May be I was expecting to much, I have only been on mine for 2 1/2 years but certainly did not plan on or for see a need to change it from what I have read.

Offline tryingtostay

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Re: HIV treatment outcomes continue to get better, says large analysis
« Reply #4 on: January 06, 2019, 08:51:01 am »
I'm sorry I don't know why I seemed to think there was some sort of connection. 

Apologies 

Offline JimDublin

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Re: HIV treatment outcomes continue to get better, says large analysis
« Reply #5 on: January 06, 2019, 09:17:40 am »
They seem to be happy that people are still undetectable on their first regime after 3 years, I would have expected that now a days as a normal occurrence. I have read plenty of people posting on this forum who have been on the same regime for much longer than that with out problems.

May be I was expecting to much, I have only been on mine for 2 1/2 years but certainly did not plan on or for see a need to change it from what I have read.

Well three-quarters between 2011 and 2015 is not bad, since 2011 treatments have again changed so it would not surprise me if this figure over 2015 - 2021 would not be slightly higher again

That said you will always have a group although apparently more the minority in the initial months/years who change regime, when you thik of it things like; Insurance changes, newer options available, convenience changes to single pill regime's or regime's less restrictive on diet, changes in needs/aging, side effects etc etc

Some of these were noted in the study and I expect there are more real world reasons

Jim
« Last Edit: January 06, 2019, 09:25:14 am by JimDublin »
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Offline Mightysure

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Re: HIV treatment outcomes continue to get better, says large analysis
« Reply #6 on: January 07, 2019, 03:15:26 pm »
My VL was so low they couldn't do a resistance test but I went on Complera/Odefsey.  I often wonder if the meds are doing anything

Hey! I haven't met anyone else who's experienced this! Were you nervous about the treatment not working like I was?

 


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