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Author Topic: Institut Pasteur - New approach for targeting HIV reservoirs  (Read 550 times)

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Offline Prince_Bernhard

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Institut Pasteur - New approach for targeting HIV reservoirs
« on: December 27, 2018, 11:18:29 am »
AIDS an approach for targeting HIV reservoirs
Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus it is their metabolic (or energy-producing) activity1 that enables the virus to multiply. Thanks to metabolic activity inhibitors, the researchers have managed to destroy these infected cells, or "reservoirs", ex vivo. Their findings were published in the journal Cell Metabolism on December 20, 2018.

Press Release by Institut Pasteur: https://www.pasteur.fr/en/press-area/press-documents/aids-approach-targeting-hiv-reservoirs
Research: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30734-4

Research on HIV/AIDS is one of the major targets of the Institut Pasteur in Paris. Institut Pasteur scientists discovered the HIV-1 virus (a discovery that was recognized by the 2008 Nobel Prize in Medicine).

This recent press release is all over the internet. I was surprised that there was nothing on POZ re this. Good things happening! I look forward to the further trial results.

Offline Jim Allen

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Re: Institut Pasteur - New approach for targeting HIV reservoirs
« Reply #1 on: December 27, 2018, 12:09:06 pm »
Look it's always good to see the mechanics being reviewed always interesting and thanks for sharing

Although I must say that plenty of ex vivo studies have shown lessons and workings not reflected in the body or things turn out to be simply more complex "in vivo" (The living body) so if I was a test tube I would be estatic at this stage in HIV development as everything seems to be a cure or a fix, but alas i'm not a test tube and so instead I tend to focus more on "in vivo" studies as a patient  ;)

We will see if this goes into "in vivo" phase 1, if it than reaches phase 2/3 then it's maybe worth more attention at patient/public levels is my opinion.

This lab result publications is more about getting word out before gaing sponsoring/PR/ development support  and announcing the wish to presue it as an avenue
« Last Edit: December 27, 2018, 12:21:58 pm by JimDublin »
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