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Author Topic: People with multidrug resistant HIV reach UD with Trogarzo antibody + ART  (Read 429 times)

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Offline Jim Allen

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Study was aimed at people with multidrug-resistant HIV who during the study were given the antibody treatment Trogarzo (ibalizumab) + ART and they reached viral suppression for a year.


In Full: https://www.poz.com/article/trogarzo-can-keep-viral-load-suppressed-least-year

In Short:
The participants had HIV that was resistant to at least one medication in three or more classes of antiretrovirals (ARVs). On day seven of the study they received a 2,000 milligram infusion of Trogarzo. On day 14, they were started on a standard ARV regimen optimized based on drug resistance testing. Starting on day 21, they received an 800 mg infusion of Trogarzo every 14 days.

Seventeen participants (43 percent) achieved a fully suppressed viral load 24 weeks into the study. Of the 31 participants who finished the 24-week study, 27 entered the expanded access phase. Twenty-four of them completed the additional 24 weeks of follow-up; of these, 16 (67 percent) had a fully suppressed viral load at the end of that period.

Of those still on treatment by the end of the expanded access phase, the median reduction in viral load was 2.5log10, or a 99.68 percent reduction.

All 15 of those who entered the expanded access phase with a fully suppressed viral load maintained that status 24 weeks later.
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