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Author Topic: Stribild and Statins  (Read 710 times)

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Offline Tony_Wanch

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  • Posts: 8
Stribild and Statins
« on: November 05, 2018, 01:05:33 am »
I am old and have high cholesterol , diagnosed and treated for HIV with Stribild since Jan 2017 . I have been told not to take statin, Lepitor etc, because of Stribild contraindication  . My cardiologist says my cholesterol reading is extremely high amd I must take the medicine. However neither doctor can tell me what can be a safe replacement  .
I am a bit depressed because my HIV doctor seems not to anticipate or explain events  . 
I welcome advice  thanks T

Offline MarkintheDark

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  • Posts: 127
Re: Stribild and Statins
« Reply #1 on: November 05, 2018, 07:27:21 am »
Perhaps I can help, Tony.  For reference, I was a participant in a blind study for several years between Stribild and Genvoya, which contained an updated version of tenofovir.  During most of that study I was also on Lipitor, and they were aware of it.  At the end of the study, I found out I was part of the Genvoya group.

The issue seems to be the tenofovir.  I ran some quick research - to be clear, I AM NOT A PHARMACOLOGIST - and indeed Lipitor, as of 2012, was contraindicated with Stribild's tenofovir disoproxil fumarate (TDF).  Genvoya's revised formulation was tenofovir alafenamide (TAF).

I would absolutely encourage you to dig into your own research - I hope I've narrowed it a bit for you - but I can't find anything the contraindicates TAF oral with Lipitor.  Caveat, I'm speaking of standalone TAF (vemlidy).

https://www.drugs.com/drug-interactions/atorvastatin-with-vemlidy-276-0-3773-18287.html

Again, I'd encourage you to dig further into this yourself with reputable sites and take what you find to your doc.  You're your own best advocate.
« Last Edit: November 05, 2018, 07:47:48 am by MarkintheDark »
HIV dx - 02/93
AIDS dx - 07/01
Rilpivirine/Cabotegravir guinea pig since 01/17

Offline MarkintheDark

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  • Posts: 127
Re: Stribild and Statins
« Reply #2 on: November 05, 2018, 09:40:24 am »
An update, Tony.  Today happened to be my monthly with the NP who administered the study, so I asked him about your concern.

As he tells me, it also seems that the cobicistat used (a type of medicine called a pharmacokinetic enhancer) was more the issue with Stribild's interaction with statins. 

The news you'll be pleased to hear is that, indeed, he tells me there is no such statin restriction with Genvoya.  And Genvoya is easier on your kidneys and bones.  Nor, for that matter, is there any such restriction with Biktarvy if you'd like to go that route.  Sounds to me like a simple change and you're good.
« Last Edit: November 05, 2018, 09:52:07 am by MarkintheDark »
HIV dx - 02/93
AIDS dx - 07/01
Rilpivirine/Cabotegravir guinea pig since 01/17

Offline bocker3

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  • You gotta enjoy life......
Re: Stribild and Statins
« Reply #3 on: November 05, 2018, 09:42:40 am »
You need to have your doctors talk with each other, if they are giving conflicting advise.
 
Drugs having interactions with each other does not always preclude you from taking them.  My statin (atorvastatin) is "contraindicated" with a couple of my HIV drugs, yet I have been taking it for years without issue.  My doctor monitors it, of course.
Ultimately, it will come down to the risk of taking the drug and possible side effects vs. the risk of NOT taking it (possible heart attack).  My family history of cardiac related deaths, made the "risk" of taking this statin a no-brainer.  Men in family rarely saw the age of 50 prior to Statins.

This is not something you should research on your own -- take your findings and talk to your doctor about it.  A good place to start is to talk with your Pharmacist and have him/her help you understand the risk of taking this drug with your current meds.

Good Luck.
Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2015 969/28% <20

Offline MarkintheDark

  • Member
  • Posts: 127
Re: Stribild and Statins
« Reply #4 on: November 05, 2018, 10:35:35 am »
I'll add that if your HIV doc isn't up on Stribild vs. Genvoya, a rather basic comparison where HIV meds are concerned, it's probably time to find another doc.
HIV dx - 02/93
AIDS dx - 07/01
Rilpivirine/Cabotegravir guinea pig since 01/17

Offline Jim Allen

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Re: Stribild and Statins
« Reply #5 on: November 05, 2018, 10:49:55 am »
You need to have your doctors talk with each other, if they are giving conflicting advise.
 
Drugs having interactions with each other does not always preclude you from taking them.  My statin (atorvastatin) is "contraindicated" with a couple of my HIV drugs, yet I have been taking it for years without issue.  My doctor monitors it, of course.
Ultimately, it will come down to the risk of taking the drug and possible side effects vs. the risk of NOT taking it (possible heart attack).  My family history of cardiac related deaths, made the "risk" of taking this statin a no-brainer.  Men in family rarely saw the age of 50 prior to Statins.

This is not something you should research on your own -- take your findings and talk to your doctor about it.  A good place to start is to talk with your Pharmacist and have him/her help you understand the risk of taking this drug with your current meds.

Good Luck.
Mike

OP I just wanted to add that I think this is good advice from Mike, you need to get them talking to each-other and hand over your findings to the doctor, talk to a qualified pharmacist.

I also agree with MarkintheDark comment about considering a different doctor if they don't listen, I say this because all in all sooner of later simply with aging & life etc the odds are we will all be taking multiple meds for multiple reasons, so you need to have a doctor who understands that or can cope with this simple concept.

Jim
« Last Edit: November 05, 2018, 10:52:54 am by JimDublin »
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Offline newone

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  • Posts: 68
Re: Stribild and Statins
« Reply #6 on: November 12, 2018, 08:45:33 pm »
I have been on Liptor and Stribild for about two years, soon I am going to switch from Stribild to Genvoya and keep taking Liptor.
Sustiva, Truvada, Complera, Stribild

Offline wardp

  • Member
  • Posts: 118
Re: Stribild and Statins
« Reply #7 on: November 24, 2018, 08:21:19 pm »
google liverpool hiv drug interactions checker
Diagnosed 20,July 2017. Cd4 289, 21% vld .3,462 Started atripla 4 Aug 2017 5oct 2017 cd4 384 21%, vl ud less than 20. Switch to complera 4 Nov 2017 switched to stribild 15 the Nov. Switched to truvada efavirence 200mgx2 14 Dec 2017, 2 Feb 2018, us cd4  466, 25%  CD 8 ,595, 32%..1 may 2018
switched  to instgra truvada.7th june switched to truvada  nevirapine stavudine. .21 june switched to truvada nevirapine. X 2 a day...9 aug 2018 ud. 2n Nov 2018 CD 4. 455..22.70% 13th Nov switched  to lamivir and nevirapine  due to kidney issues...jan 10,2019 UD..may 13 2019 ud  cd4 482 28%

 


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