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Author Topic: ViiVís Long-Acting Injectable HIV Regimen Boasts Good 3-Year Results  (Read 1002 times)

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Offline Jim Allen

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Full write-up

In short:

ViiV Healthcare has presented three-year data from a clinical trial of a long-acting injectable formulation of cabotegravir and Edurant (rilpivirine), indicating that the regimen is safe and effective as HIV treatment when given every four or eight weeks.

Presenting their findings at the HIV Glasgow Drug Therapy meeting in Scotland, researchers conducted a Phase II multicenter, parallel group open-label trial, called LATTE-2, of intramuscular injections of long-acting cabotegravir and Edurant.

Cabotegravir is a non-nucleoside reverse transcriptase inhibitor (NNRTI); Edurant is an integrase inhibitor.

After a 20-week period during which HIV-positive participants received oral therapy with cabotegravir and Epzicom (abacavir/lamivudine), virally suppressed participants were randomly assigned two to two to one to receive long-acting injectable cabotegravir and Edurant every eight weeks or every four weeks or to stay on the oral three-drug regimen. After 96 weeks of oral treatment, those in the oral treatment group were permitted to choose either dosing interval of the injectable regimen.

After 160 weeks of treatment, 90 percent (104 or 115) of those in the four-week injectable dosing group and 83 percent (95 of 115) of those in the eight-week injectable dosing group remained virally suppressed. At this point in the study, of those in the oral treatment group who elected to switch to injectable treatment at week 96, 97 percent (33 of 34) of those in the eight-week group and 100 (10 of 10) of those in the four-week group were virally suppressed.

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Offline MarkintheDark

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Re: ViiVís Long-Acting Injectable HIV Regimen Boasts Good 3-Year Results
« Reply #1 on: October 31, 2018, 04:56:09 pm »
As one of the study participants in a concurrent trial, I'll add my two bits.  I'm an LTS whose genotyping indicated resistance to some ARV combos.

What I found remarkable was that this therapy eventually lifted my numbers out of AIDS territory (<200) for the first time in over a decade.

My group was given oral cabotegravir and rilpivirine for 30 days at the outset to monitor for adverse reactions, monthly injections following.  We've a second group that was randomly selected after a year for bi-monthly injections.

I'll add that I'll gladly answer any questions y'all have about the treatment, either here or via PM.
HIV dx - 02/93
AIDS dx - 07/01
Rilpivirine/Cabotegravir guinea pig since 01/17

Offline Cosmicdancer

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Re: ViiVís Long-Acting Injectable HIV Regimen Boasts Good 3-Year Results
« Reply #2 on: November 01, 2018, 10:15:19 am »
Mark, did you notice any side effects from the monthly injections other than some site soreness? Is the injection site in your upper arm, like with the typical vaccine?
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
2/2008 - 5/2015 - undetectable on Atripla
May, 2015 - UD, switched to Complera
September, 2015 - UD, 980 cd4, switched to Stribild (Complera interacted with acid reflux medication)
January, 2016 - Stribild, UD, 950 cd4
June, 2016 - UD, 929 cd4

Offline MarkintheDark

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Re: ViiV’s Long-Acting Injectable HIV Regimen Boasts Good 3-Year Results
« Reply #3 on: November 01, 2018, 01:37:34 pm »
Keeping in mind I'm only one participant, ymmv.

The two injections are given up towards the glutues medus, one each side, top of the gluteus maximus with high-gauge needles.  That's to say it's not like a scary small-gauge syph shot.  The only short-lived discomfort I've had is with the Rilpivirine component which I believe may have to do with higher viscosity.  Therefore, I switch sides from month to month.  Also, my NP and I discovered that administration while prone was preferable since the glutes would not be tensed.

At the outset, Viiv provided reusable ice packs to alleviate swelling, etc.  Did nothing for me.

Aftereffects vary from person to person.  For me, the sites ache for 24 or even up to 48 hours afterwards (depending on if I'm dealing with other health issues).  Tylenol helps.  In my experience, there's been no redness, swelling or rash.  It will sometimes itch for 24 hours or so.  As an LTS, I do have problems with fatigue in general.  I cannot quantify it, but my sense has been the fatigue is worse for at least 24 hours following the injection.  I therefore pretty much keep my calendar clear during that time.  Again, that's just speaking to one person's experience. 

Obviously I'm happy with the unexpected results of the treatment.  My CD4 seems to have settled into the mid-upper 200s.  I don't want to discount that the protocol is being administered by an NP with whom I've had a terrific clinical relationship for eight years.  Office visits aren't a chore since it's more like I'm visiting a friend...well, in fact I am.
« Last Edit: November 01, 2018, 01:41:02 pm by MarkintheDark »
HIV dx - 02/93
AIDS dx - 07/01
Rilpivirine/Cabotegravir guinea pig since 01/17


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