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Author Topic: Spanish Doctors ‘Eliminate’ Hiv From Patient In Stem Cell Transplant Trial  (Read 1442 times)

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Offline geobee

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This is a stem-cell Delta-32 experiment (aka Tim Brown).  Here's the juicy part (I always take my juice with a grain of salt!)

Scientists from the Institute for AIDS Research IrsiCaixa in Barcelona and the Gregorio Maranon Hospital in Madrid have managed to remove the virus from the blood and tissues of six patients using the treatment.

But the research, published on Monday in the Journal of Internal Medicine, said one patient now has no antibodies fighting the infection, suggesting it has been completely eliminated.

Here's the article -- it's short:

http://www.theolivepress.es/spain-news/2018/10/16/spanish-doctors-eliminate-hiv-from-patient-in-stem-cell-transplant-trial/


Offline JimDublin

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Well time will tell with this one, we all recall the kids who were "cured" but when testing a few years later it was back. Long term remission perhaps

Quote
The patients are keeping up their antiretroviral treatment,


Currently the Berlin patient has a functional cure but even than he still has HIV in some tissues just not replicating or its in a dormet state in laymens terms.

Always something to learn though

Jim
« Last Edit: October 16, 2018, 05:31:25 pm by JimDublin »
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Offline geobee

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I thought it was interesting that the one patient had no anti-bodies at all.  If he goes for several years without anti-bodies -- well, that would be something.  Sign me up! 

[I *did* try to sign up a few years ago for a Sangamo D32 trial.  They couldn't get enough HIV out of my blood to do a genotype and I was DQ'd]

Offline JimDublin

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Even the Berlin patient had a few negative Elisa results if i recall for a while, anyhow i suspect it will be more a possible functional cure one day for some, with longer treatment gaps if it works out, we will see how time goes on. In the meantime it will be interesting to see the published results from this latest phase.

Jim
« Last Edit: October 16, 2018, 07:31:58 pm by JimDublin »
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Offline JimDublin

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Here is an abstract BTW and ill fish out the full one later this week.

http://annals.org/aim/article-abstract/2707334/mechanisms-contribute-profound-reduction-hiv-1-reservoir-after-allogeneic-stem

Quote
Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant

Abstract
Background:
The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT), including a case of HIV cure, are not fully understood.

Objective:
To investigate the mechanism of HIV-1 eradication associated with allo-HSCT.

Design:
Nested case series within the IciStem observational cohort.

Setting:
Multicenter European study.

Participants:
6 HIV-infected, antiretroviral-treated participants who survived more than 2 years after allo-HSCT with CCR5 wild-type donor cells.

Measurements:
HIV DNA analysis, HIV RNA analysis, and quantitative viral outgrowth assay were performed in blood, and HIV DNA was also measured in lymph nodes, ilea, bone marrow, and cerebrospinal fluid. A humanized mouse model was used for in vivo detection of the replication-competent blood cell reservoir. HIV-specific antibodies were measured in plasma.

Results:
Analysis of the viral reservoir showed that 5 of 6 participants had full donor chimera in T cells within the first year after transplant, undetectable proviral HIV DNA in blood and tissue, and undetectable replication-competent virus (<0.006 infectious unit per million cells). The only participant with detectable virus received cord blood stem cells with an antithymocyte globulin–containing conditioning regimen, did not develop graft-versus-host disease, and had delayed complete standard chimerism in T cells (18 months) with mixed ultrasensitive chimera. Adoptive transfer of peripheral CD4+ T cells to immunosuppressed mice resulted in no viral rebound. HIV antibody levels decreased over time, with 1 case of seroreversion.

Limitation:
Few participants.

Conclusion:
Allo-HSCT resulted in a profound long-term reduction in the HIV reservoir. Such factors as stem cell source, conditioning, and a possible “graft-versus-HIV-reservoir” effect may have contributed. Understanding the mechanisms involved in HIV eradication after allo-HSCT can enable design of new curative strategies.

Primary Funding Source:
The Foundation for AIDS Research (amFAR).
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Offline Ptrk3

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Offline Cosmicdancer

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Is there more information about the 6 people who underwent the stem cell transplant?  Were they people who had some type of cancer or leukemia? They say they studied 6 people who had survived 2 years after treatment, did some people die? Did they give them chemo to wipe out their existing immune system? How arduous was the transplant process, and what side effects did they experience? 

Okay, after posting this I noticed the link to the Poz article which addressed most of my questions.

I look forward to reading more articles about this.
« Last Edit: October 19, 2018, 07:12:27 pm by Cosmicdancer »
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
2/2008 - 5/2015 - undetectable on Atripla
May, 2015 - UD, switched to Complera
September, 2015 - UD, 980 cd4, switched to Stribild (Complera interacted with acid reflux medication)
January, 2016 - Stribild, UD, 950 cd4
June, 2016 - UD, 929 cd4

Offline CaveyUK

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maybe it's just me, but if a possibility to send HIV into 'remission' involves non-routine, high-risk highly invasive surgical procedures, I think I'd prefer to just stick with my pill-a-day...
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Offline Gladragsguy

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And we won't even mention the prohibitively astronomical cost of this type of treatment, or that finding the right donor is extremely difficult, or the idea that you could possibly do more damage to yourself than when you started out, or that you might have to be on even more expensive anti-rejection medications possibly for the rest of your life?  All of this for a chance to remove the Scarlet H? Power to the researchers because research like this might help us to find the cure...but this is not it...just research into the mechanism. Fight stigma that's the real cure.

Offline fabio

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I,too, believe that if this procedure were to happen,the risks would be many. Getting "cured" is nice and all,but having a functioning life is the ideal and the arvs are giving us that.

 


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