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Author Topic: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages  (Read 1710 times)

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Offline MitchMiller

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BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« on: October 03, 2018, 02:27:59 am »
This drug shows promise in humans to reduce viral load in macrophages when taken with standard ARV regimens.

http://www.biotron.com.au/wp-content/uploads/2018/09/Significant-Immunological-Outcomes-in-BIT225-HIV-1-Clinical-Trial.pdf

Offline Jmarksto

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Re: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« Reply #1 on: October 03, 2018, 03:09:22 pm »
This clinical trial is particularly interesting and there is a bunch of interesting “teasers” in this press release – from using new assays, a reduction of CD163 levels, and the use of the word “eradication” of the virus from macrophage reservoirs. Biotron’s stock has jumped some 600% in the last week or so as well….This will be one to watch over the next year at conferences for more detail and to see if they get funding for the next round of clinical trials.
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45% VL 25
02/25/14 CD4   792/37% VL UD
07/09/14 CD4 1004/39% VL UD
11/03/14 CD4   711/34% VL UD
03/13/15 CD4   833/36% VL UD
04/??/15 Truvada & Tivicay
06/01/15 CD4 1100/50% VL UD
10/16/15 CD4   826/43% VL UD
??/??/2017 Descov & Tivicay
2017 VL UD, CD4 stable around 850
2018 VL UD, CD4 stable around 850

Offline geobee

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Re: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« Reply #2 on: October 05, 2018, 12:52:50 pm »
Wikipedia says it cures Hep C in 12 weeks:

https://en.wikipedia.org/wiki/BIT225

" In addition, the drug also has been credited with curing hepatitis C after 12 weeks of treatment."

The price may have jumped 600% but it's still a penny stock.

Here's an interesting article from SeekingAlpha (scroll down to the BIT225 part).
 Written April 23, 2018:

"Biotron's BIT225 may serve as the key in the fight against inaccessible pockets of HIV. Biotron's phase 1b/2a clinical trials results indicated that in combination with cART, BIT225 successfully reduced HIV RNA, inhibited replication in myeloid -lineage cells, and crossed the blood-brain barrier to reach latent viral reservoirs. With the promise of reaching previously untouched sites of disease, BIT225 may work in combination with today's approved cART medicines to collectively annihilate HIV once and for all. With preparations being made for a phase 2b study, it has yet to be seen just how safe and effective it will be in treating large cohorts of HIV-positive patients."

https://seekingalpha.com/article/4165622-new-generation-novel-hiv-small-molecule-antivirals

« Last Edit: October 05, 2018, 01:09:17 pm by geobee »

Offline Mindless

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Re: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« Reply #3 on: October 06, 2018, 04:02:09 am »
Hi,

I’m not an expert at any rate but the claims here are so huge I wonder if there’s a solid scientific basis or it’s just speculation.

I did a small research on poz site and seems like this BIT225 has been around since 2006 (eg here https://forums.poz.com/index.php?topic=1898.msg20581#msg20581) with similar claims:

Unlike existing drugs, BIT225 is active in the viral reservoir in the body, and complete elimination of HIV from infected patients is not possible unless these underlying reservoirs of infection can be cleared. BIT225 represents an opportunity to eliminate the underlying seat of infection, potentially leading to a cure for HIV.“

They claim such astonishing potential applications, yet no mention about next steps needed/planned or a schedule? 12 years have passed since then and still no concrete evidence?

Just wondering

Offline geobee

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Re: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« Reply #4 on: October 09, 2018, 11:23:39 am »
Well as the press release says in the post above, they completed a clinical trial of treatment-naive people in Thaliand.  The drug didn't have any effect on speeding up the reduction in viral load (they also were taking Atripla) but it does appear to reduce the amount of virus in macrophages (where Atripla can't reach). 

The date of the PR is 9/29/2018 -- so it's recent (at the time of this writing).

I'm curious as to what their results were in mice or monkeys.  Did they take infected animals and rid them of virus?  Presumably if they'd had, we would have seen something about that.

Offline Prince_Bernhard

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Re: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« Reply #5 on: October 09, 2018, 09:56:54 pm »
In their latest shareholder letter dated 9 October, the following bold statements are made:

Recapping those headlines:
1. BIT225 is having a unique effect in patients, over and above what is seen with current antiretroviral drugs used to treat HIV­1 infection.
2. The data from the trial are consistent with targeting and eradication of virus from macrophage reservoir cells by BIT225.

http://www.biotron.com.au/wp-content/uploads/2018/10/Shareholder-Update.pdf

At the end of this month, the ceo of Biotron will give a presentation at a conference. Possibly the trial results will be presented there.

I am positive that this at least looks like something in the direction of a cure, and possibly a (full) eradication of the virus from the body. The trial results could confirm this.

Let’s keep our hopes up!

Offline Jim Allen

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Re: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« Reply #6 on: October 10, 2018, 12:08:56 am »
Shareholder letters and updates.

BIT225-009 seems to be a small phase 2 study. Nothing to get excited about, we seen plenty of them with great promise over the years yield further understanding in the targeting of hard to reach cells or latent reservoirs.

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372075

Lets say even for a moment all goes well and 5 or 10 years down the line this drug is added in combination of standard treatment, well even with targeting of macrophage reservoir cells their are still plenty of places HIV is lying dormant in the body that have not been addressed. Its an integrated virus in the human body (DNA/Tissue), a full cure is not in sight and I can only urge caution to getting ones hopes up.

I understand the need for the company to make it big news, but don't get sucked too much into the hype. Its for the stakeholder. The forum is filled with people betting on the next solution that simply does not work out in real life.

@Prince_Bernhard

Welcome to the forum.

As a new member its can you please open a introduction thread in the "I just tested positive" section and please introduce yourself to the other members of the forum, things like. How you are getting on? What treatment are you taking, how is that going? What your labs are like etc etc

Thank you

Jim
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Offline Mindless

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Re: BIT225 HIV-1 Clinical Trial Results Target Virus In Macrophages
« Reply #7 on: October 17, 2018, 10:20:51 am »
Lets say even for a moment all goes well and 5 or 10 years down the line this drug is added in combination of standard treatment, well even with targeting of macrophage reservoir cells their are still plenty of places HIV is lying dormant in the body that have not been addressed. Its an integrated virus in the human body (DNA/Tissue), a full cure is not in sight and I can only urge caution to getting ones hopes up.

I understand the need for the company to make it big news, but don't get sucked too much into the hype. Its for the stakeholder. The forum is filled with people betting on the next solution that simply does not work out in real life.

Thanks for clarifying, as usual!

 


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