Welcome, Guest. Please login or register.
July 18, 2019, 01:50:03 pm

Login with username, password and session length

  • Total Posts: 746094
  • Total Topics: 62412
  • Online Today: 305
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 am)
Users Online
Users: 5
Guests: 266
Total: 271


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Resting Immune Cells May Harbor HIV for Decades  (Read 847 times)

0 Members and 1 Guest are viewing this topic.

Online Jim Allen

  • Administrator
  • Member
  • Posts: 12,491
  • Twitter @JimAllenDublin
    • HIV Lessons
Resting Immune Cells May Harbor HIV for Decades
« on: September 20, 2018, 04:12:37 pm »
Interesting read, particularly on the blip case spotted during the study finding the viral load from the blip was 20 years old copies from the reservoir.

I'm always thinking to myself, blips are caused by sneezing too hard now I know why, dislodged some old virus lol ;D


Full writeup here: https://www.poz.com/article/resting-immune-cells-may-harbor-hiv-decades-poz

Resting Immune Cells May Harbor HIV for Decades
Such latently infected cells remain under the radar of antiretroviral treatment, which only works on replicating cells.

The unreplicating, or latently, infected cells that are a major component of the HIV reservoir may harbor virus for many years, even decades, despite effective antiretroviral (ARV) treatment.

Publishing their findings in the Proceeding of the National Academy of Sciences, researchers in British Columbia have used a novel genetic-analysis process to map the evolution of HIV within individuals. With this map in hand, they were able to then estimate the lifespan of latently infected cells, which skirt the effects of ARVs because such treatment only works on replicating cells.

The existence of such latently infected cells is the reason HIV treatment must be maintained for life. Without ARVs, such cells may spring into action at any time and start churning out new copies of the virus, ultimately raising an individualís viral load.

The British Columbian researchers have at their disposal a rich trove for their research: stored blood samples drawn from the local HIV population over time. Originally taken for viral load and drug resistance testing, these samples date as far back as 1996.

HIV rapidly evolves, even within a single personís body. Seeking to chart such evolution, the investigators used a method known as molecular phylogenetics to reconstruct the family tree of strains of the virus within individuals. They used as their reference virus in blood samples taken over time before such people started ARVs, as well as genetically sequenced, latently infected virus drawn from individuals for up to 10 years after they started HIV treatment.

The population of viruses integrated into the latently infected immune cells belonged to many points on the viral family tree, stretching back through the years. In other words, the virus that infected these cells did so at many different points in time, as indicated by their different evolutionary states, which were in a sense frozen in amber when HIV entered a cell, keeping the virus in a latent state. The oldest such virus dated back more than 20 years, meaning that latently infected cells may live even that long.

In one particularly notable case, an individual had whatís known as a viral blip while on successful ARV treatmentóa short, relatively low rise in viral load that quickly returned to an undetectable state. The viruses found during the blip were highly genetically diverse, belonging to a 20-year span on the individualís viral family tree. This finding suggested that virus in the personís latent reservoir had spontaneously reactivated, and that the reservoir itself was robust in size.

The study authors concluded that their findings provide a rich new way of understanding how HIV persists in the body, one that will be valuable for future cure research.
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP


Terms of Membership for these forums

© 2019 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.