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Author Topic: Immunotherapy Shows Promise for HIV-Related Kaposi Sarcoma  (Read 779 times)

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Online Jim Allen

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Immunotherapy Shows Promise for HIV-Related Kaposi Sarcoma
« on: September 12, 2018, 02:07:00 pm »
Very small sample size, still promising results for further research


Full write-up: https://www.poz.com/article/immunotherapy-shows-promise-hivrelated-kaposi-sarcoma

In short:
Immunotherapy Shows Promise for HIV-Related Kaposi Sarcoma
Six out of nine patients experienced cancer remission with Opdivo or Keytruda.

Treatment with immune checkpoint inhibitors led to complete or partial tumor shrinkage in two thirds of HIV-positive people with Kaposi sarcoma, and none of the treated patients experienced disease progression, according to a recent report in Cancer Immunology Research, a journal published by the American Association for Cancer Research (AACR).

“Based on these results, we think that PD-1 checkpoint blockade may present a promising, novel therapeutic option for HIV-associated Kaposi sarcoma with high efficacy and low toxicity,” Natalie Galanina, MD, of Moores Cancer Center at the University of California San Diego said in an AACR press release.

Once frequently seen among people with AIDS, Kaposi sarcoma (KS) decreased dramatically after the advent of effective antiretroviral treatment as fewer HIV-positive people developed advanced immune suppression with very low CD4 T-cell counts. Nonetheless, KS remains the most common AIDS-defining cancer, even as rates of some non-AIDS-related cancers are rising as people with HIV live longer.
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