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Author Topic: Absorption time of drugs  (Read 691 times)

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Offline an92

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  • Posts: 24
Absorption time of drugs
« on: August 07, 2018, 11:41:41 am »
I wonder if someone can clarify scientifically, the time the body takes to absorb the following meds:
Descovy
Tivicay.

I asked my doctor, and she said the digestion process takes 8 hours (I think she didn't understand what I was asking).

The pharmakinetics section of the drug instructions say that:
Dolutegravir (Tivicay) takes up to 2 hours fasted, and up to 5 hours with a fat meal to reach the Tmax (max concentration in the blood).
Descovy takes less time: between 1 and 3 hours.

However, that's the Tmax, but I can't find information for how long it takes to actually be absorbed from your intestine once you take it.

This information could be very important for me,

Offline CaveyUK

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Re: Absorption time of drugs
« Reply #1 on: August 08, 2018, 05:14:17 pm »
Are you having problems staying undetectable? It's the only thing I could think of that would prompt this level of analysis...

If that's the case, there are tests that can be run to check absorption, so is worth a conversation with your doctor.
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Offline an92

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Re: Absorption time of drugs
« Reply #2 on: August 09, 2018, 04:57:40 am »
Hi Cavey,

No I'm not having problems thankfully.

It was more out of personal interest, I was investigating some things about the drugs I'm taking and was just asking if someone knew more.

Especially because there seemed to be inconsistencies between what two doctors told me, and what it said on the drug information leaflets.

Offline daveR

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  • Posts: 90
Re: Absorption time of drugs
« Reply #3 on: August 09, 2018, 05:26:53 am »
I do not take the combo you are on but mine does include Edurant which requires a certain PH/stomach acid level to be absorbed. The manufacturer recommends that you do not take antacids for four hours after taking the pill. I assume that is the time required to get full absorption. But that is just my guess, around 4 hours.

Offline JimDublin

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Re: Absorption time of drugs
« Reply #4 on: August 09, 2018, 07:41:34 am »
Not quite sure what your asking/looking for.

I agree with CaveyUK & Dave.
Absorption will vary depending on food, other medication as well and person to person within limits.

Im on holiday right now but when im back in the office if your still looking for info ill dive into it and see what I can dig up.

Jim

https://www.drugs.com/ppa/dolutegravir.html

Quote
Absorption
Dolutegravir is rapidly absorbed following oral administration, with median Tmax at 2 to 3 hours post dose for
tablet formulation.
Food increased the extent and slowed the rate of absorption of dolutegravir. Bioavailability of dolutegravir
depends on meal content: low, moderate, and high fat meals increased dolutegravir AUC(0-∞) by 33%, 41%,
and 66%, increased Cmax by 46%, 52%, and 67%, prolonged Tmax to 3, 4, and 5 hours from 2 hours under
fasted conditions, respectively. These increases may be clinically relevant in the presence of certain integrase
class resistance. Therefore, Tivicay is recommended to be taken with food by patients infected with HIV
with integrase class resistance (see section 4.2).
The absolute bioavailability of dolutegravir has not been established
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