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Author Topic: Can HIV meds cause Parkinsons?  (Read 944 times)

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Offline NickMark

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Can HIV meds cause Parkinsons?
« on: June 02, 2018, 11:11:07 am »
Has anyone considered whether the long term effects of HIV meds can cause or contribute to Parkinson's symptoms.  Here is an interesting article that talks about Parkinson's as an autoimmune disorder: 


Offline leatherman

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Re: Can HIV meds cause Parkinsons?
« Reply #1 on: June 02, 2018, 11:46:15 am »
HIV isn't an autoimmune disease and ARVs affect the lifecycle of the HIV (the virus), so how do you see the connection?
leatherman (aka mIkIE)

chart from 1992-2017

Offline NickMark

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Re: Can HIV meds cause Parkinsons?
« Reply #2 on: June 02, 2018, 11:59:29 am »
The article indicates "The new study found that T cells can be tricked into thinking dopamine neurons are foreign by the buildup of damaged alpha-synuclein proteins, a key feature of Parkinson's disease."

So the overvigilant T-cells begine attacking the dopamine neurons.  I think it would be worth exploring whether these T-cells are extravigilant for some reason after years of exposure to HIV meds. 

Offline Jim Allen

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Re: Can HIV meds cause Parkinsons?
« Reply #3 on: June 02, 2018, 12:59:40 pm »
Still not seeing the connection from this article. To be honest if HIV and Parkinson had a correlation we would see the increase under the HIV population and so far nada to suggest this to my knowledge. 

Mark, before you post again can you please open an introduction thread in the "I just tested positive" or "Living with HIV" section and introduce yourself, how are you doing, how is your treatment going and what your latest labs are line etc

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Offline leatherman

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Re: Can HIV meds cause Parkinsons?
« Reply #4 on: June 02, 2018, 03:04:11 pm »
these T-cells are extravigilant for some reason after years of exposure to HIV meds.
but HIV meds don't do anything to tcells. ARVs interrupt the lifecycle of the HIV virus itself. This allows your own genetically-created immune system to recover. ARVs (or HIV for that matter) don't hyper-activate your tcells; they stop HIV from using and killing your tcells.

also, while I don't have the epidemiological data/links at my fingertips right this moment (I volunteer/work with a lot of Ryan White quality management groups), I still think I wouldn't be incorrect in saying that if Parkinsons was a result of HIV or ARVs wouldn't we see data about more PLWH dealing with Parkinsons?
leatherman (aka mIkIE)

chart from 1992-2017


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