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Author Topic: Very worried. PEP questions. P24 Antigen get picked up?  (Read 1553 times)

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Offline veryscaredrightnow

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Very worried. PEP questions. P24 Antigen get picked up?
« on: April 20, 2018, 12:29:39 am »
If I was on PEP (Truvada and Isentress), would a fourth generation test pick up the p24 antigen, 26 days after exposure? I started PEP around 68 hours after exposure (Condom broke for a couple minutes, I'm a male, having vaginal sex with a female). I tested negative on this fourth generation test while I was on PEP. Furthermore, I had a third generation test 36 days after exposure (4 days after PEP finished) and that was also negative.

Is there proof that PEP would make the p24 antigen not show up in a test 26 days after exposure?


Online JimDublin

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Re: Very worried. PEP questions. P24 Antigen get picked up?
« Reply #1 on: April 20, 2018, 02:34:08 am »
Hi

You are on PEP, so what was your exposure?

PEP prevents HIV from taking hold when taken correctly and is highly effective, however post PEP you need to see if the infection has had an opportunity to take taken hold once you stop taking the PEP, hence test post finishing PEP at 6 weeks and 13 weeks for a conclusive result.

P24 is not conclusive or a standalone test, for good reason. It may pick up on an infection sooner but is no guarantee and hence its combined with an antibodies test and this remains the conclusive part beyond the window period. See antigens peak very quickly and sometimes drop off fast even before antibodies can be detected leaving a window, also as said you are on PEP so that could delay matters. In addition the p24 antigen test only looks for HIV -1 type and not the HIV-2

There is no short cut to testing.

Here's what you need to know in order to avoid hiv infection:
Use condoms for anal or vaginal intercourse, correctly and consistently, every time, no exceptions.

Keep in mind that some sexual practices which may be described as ‘safe’ in terms of HIV transmission might still pose a risk for transmission of other STI's, so please do get fully tested regularly and at least yearly for all STI's including but not limited to HIV and test more frequently if unprotected intercourse occurs

Also note that it is possible to have an STI and show no signs or symptoms and the only way of knowing is by testing.

More information on HIV Basics, PEP, TaSP and Transmission can be found through the links in my signature to our POZ pages, this includes information on HIV Testing

Kind regards

Jim

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« Last Edit: April 20, 2018, 02:41:37 am by JimDublin »
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline veryscaredrightnow

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Re: Very worried. PEP questions. P24 Antigen get picked up?
« Reply #2 on: April 22, 2018, 07:42:21 pm »
I've been having a very mild fever for the past week. I've never had a fever that lasted more than 3 days so this is scary for me. Temperature is usually under 99 fahrenheit (37.2222 Celsius). I also have some fatigue, and some minor upset stomache, and some headaches. I just took the oraquick saliva test today and it was negative. This is 32 days after PEP. Is this a good sign? Is there any report that PEP might delay Oraquick to detect antibodies?

Online JimDublin

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Re: Very worried. PEP questions. P24 Antigen get picked up?
« Reply #3 on: April 23, 2018, 02:15:03 am »
I read your post and your symptoms have nothing to do with HIV, go see your doctor and treat whatever is making you sick. Please do not post about symptoms  - Thank you.

Test as per the guidelines given and in the meantime focus on something else.

Jim
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline veryscaredrightnow

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Re: Very worried. PEP questions. P24 Antigen get picked up?
« Reply #4 on: May 18, 2018, 12:31:03 am »
Sorry what do you mean my symptoms have nothing to do with HIV? My condom broke on 2/17. I started pep (truvada and issentress) 68 hours later (I know it's late).

On 3/13, the third week of PEP, I had a fever for 2 days with no mucous. I also had various symptoms pop up like fatigue, diahrrea, sore throat, slight cough, headache, slight joint aches for 4 days around the time of the fever. I thought I was seroconverting or some of it was caused by the PEP. But PEP doesn't cause fever.

on 3/15, 26 days after exposure (23 days since beginning PEP), I was negative using a fourth generation rapid test.

On 3/21 I finished PEP. On 3/25 I tested negative for a third generation rapid blood test.

From 3/28 to 4/2 I had a slight headache everyday.

on 4/15, I started getting a fever again. This time it lasted a whole week, with no mucous again. This is 25 days after PEP ended. I thought I was seroconverting after PEP. I had a lost of appetite some days, and it felt the same as last month's illness but less severe. However, the fever lasted for a whole week this time instead of 2 days, but it was a mild fever.

4/22, 32 days after PEP ended, I took an at home oraquick test and it was negative. I also took the third generation blood finger prick test again and it was negative.

5/5, 6 weeks and 3 days (45 days) after PEP ended, I took an at home oraquick test again and it was negative.

Is this conclusive?


Online JimDublin

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Re: Very worried. PEP questions. P24 Antigen get picked up?
« Reply #5 on: May 18, 2018, 02:39:31 am »
Quote
Sorry what do you mean my symptoms have nothing to do with HIV?
Simple most of the symptoms you posted regardless of your HIV status have nothing to do with HIV and HIV is not the cause.

Quote
Is this conclusive?

Test post finishing PEP at 6 weeks and 13 weeks for a conclusive result.
I do not expect the negative result you have to change, but test to confirm that.

See a doctor about whatever is coming and going and making you feel bad so they can treat it and I hope you feel better soon.

Jim
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

 


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