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Author Topic: Anyone taking Juluca?  (Read 3033 times)

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Offline awakening

  • Member
  • Posts: 146
Anyone taking Juluca?
« on: April 03, 2018, 12:50:56 am »
My doc is recommending a switch to the two-drug combo Juluca which was recently approved in the US. Wants to move me away from Abacavir. Any members have experience with it yet to share?
~~~~
[month/date/year]
3/1/16: Tested neg (Oral swab)
6/17/16: Diagnosed poz (finger prick), confirmed w/Multispot assay
6/17/16: VL 22,900, CD4 - 524 cells/uL (30%)
7/2/16: Started Triumeq (DTG+ABC+3TC)
8/1/16: VL 30
10/4/16: VL <20, CD4 - 630 (31%)
1/4/17: VL 90
2/7/17: Undetected
4/17/17: Undetected, CD4 - 695 (33%)
7/20/17: VL 75
8/21/17: VL <20
11/27/17: VL<20
3/26/18: VL<20, CD4 - 701 (36%)
5/14/18: Switch to Juluca (DTG+RPV)
6/11/18: VL<20
7/25/18: Undetected, CD4 - 632 (38%)

Offline awakening

  • Member
  • Posts: 146
Re: Anyone taking Juluca?
« Reply #1 on: May 14, 2018, 10:14:17 am »
After almost 2 years on Triumeq I started taking Juluca today (Dolutegravir + Rilpivirine). I was tolerating Triumeq well other than some skin sensitivity and occasional hive-like rashes that are short lived (10 minutes or so). My ID doc wanted to get me away from Abacavir and also move in the direction of fewer drugs. So with Juluca I keep the Dolutegravir and replace the Abacavir/Lamivudine with Rilpivirine.

The clinicial studies found Juluca non-inferior, but it still feels a little scary adding a new medicine to the mix with the possibility of experiencing new side effects and trusting the research that shows that it's possible to maintain suppression without developing resistance with only two drugs. I will update the thread as to how it goes.

Felt a little buzzy within the first few hours of taking it, but I recall a similar feeling early on with Triumeq. It's certainly a much smaller pill. Amazing to think that this little 75mg pill can keep the virus at bay.
~~~~
[month/date/year]
3/1/16: Tested neg (Oral swab)
6/17/16: Diagnosed poz (finger prick), confirmed w/Multispot assay
6/17/16: VL 22,900, CD4 - 524 cells/uL (30%)
7/2/16: Started Triumeq (DTG+ABC+3TC)
8/1/16: VL 30
10/4/16: VL <20, CD4 - 630 (31%)
1/4/17: VL 90
2/7/17: Undetected
4/17/17: Undetected, CD4 - 695 (33%)
7/20/17: VL 75
8/21/17: VL <20
11/27/17: VL<20
3/26/18: VL<20, CD4 - 701 (36%)
5/14/18: Switch to Juluca (DTG+RPV)
6/11/18: VL<20
7/25/18: Undetected, CD4 - 632 (38%)

Online JimDublin

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Re: Anyone taking Juluca?
« Reply #2 on: May 14, 2018, 11:03:02 am »
Cool update and I think its common to have jitters when finally switching.
Do keep us posted, wishing you all the best and hope the dizziness is just excitement or initial settling in.

Jim

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PEP and PrEP

Offline awakening

  • Member
  • Posts: 146
Re: Anyone taking Juluca?
« Reply #3 on: May 16, 2018, 09:49:28 am »
Day 3 on Juluca.  No noticeable side effects.  Will get blood work after four weeks to make sure itís working properly.
~~~~
[month/date/year]
3/1/16: Tested neg (Oral swab)
6/17/16: Diagnosed poz (finger prick), confirmed w/Multispot assay
6/17/16: VL 22,900, CD4 - 524 cells/uL (30%)
7/2/16: Started Triumeq (DTG+ABC+3TC)
8/1/16: VL 30
10/4/16: VL <20, CD4 - 630 (31%)
1/4/17: VL 90
2/7/17: Undetected
4/17/17: Undetected, CD4 - 695 (33%)
7/20/17: VL 75
8/21/17: VL <20
11/27/17: VL<20
3/26/18: VL<20, CD4 - 701 (36%)
5/14/18: Switch to Juluca (DTG+RPV)
6/11/18: VL<20
7/25/18: Undetected, CD4 - 632 (38%)

Offline TH_guy

  • Member
  • Posts: 12
Re: Anyone taking Juluca?
« Reply #4 on: May 24, 2018, 07:40:04 am »
I'm on dolutegravir + rilpivirine (same a Juluca ) more than year.
Nothing to say, honestly, just works as should and no significant side effects.
Only creatinine levels can grows as both medication can increase them. Will switch to DTG + 3TC next month ( not because of side effects but simplifying only ) let you know if any changes.

Offline awakening

  • Member
  • Posts: 146
Re: Anyone taking Juluca?
« Reply #5 on: May 24, 2018, 11:28:00 pm »
DTG+3TC has not been fully proven yet. Some feel the more powerful NRTI in Triumeq was the ABC not the 3TC. The 3TC dual treatment may be relying too heavily on the DTG which we know fails as monotherapy. Time will tell...
« Last Edit: May 24, 2018, 11:40:03 pm by awakening »
~~~~
[month/date/year]
3/1/16: Tested neg (Oral swab)
6/17/16: Diagnosed poz (finger prick), confirmed w/Multispot assay
6/17/16: VL 22,900, CD4 - 524 cells/uL (30%)
7/2/16: Started Triumeq (DTG+ABC+3TC)
8/1/16: VL 30
10/4/16: VL <20, CD4 - 630 (31%)
1/4/17: VL 90
2/7/17: Undetected
4/17/17: Undetected, CD4 - 695 (33%)
7/20/17: VL 75
8/21/17: VL <20
11/27/17: VL<20
3/26/18: VL<20, CD4 - 701 (36%)
5/14/18: Switch to Juluca (DTG+RPV)
6/11/18: VL<20
7/25/18: Undetected, CD4 - 632 (38%)

Offline TH_guy

  • Member
  • Posts: 12
Re: Anyone taking Juluca?
« Reply #6 on: May 25, 2018, 12:32:10 am »
DTG+3TC has not been fully proven yet. Some feel the more powerful NRTI in Triumeq was the ABC not the 3TC. The 3TC dual treatment may be relying too heavily on the DTG which we know fails as monotherapy. Time will tell...
Yes, I know. On the time I start DTG + RPV it was also not fully proven. For me looks good enough.

Offline awakening

  • Member
  • Posts: 146
Re: Anyone taking Juluca?
« Reply #7 on: June 03, 2018, 04:05:07 pm »
Starting my fourth week on Juluca.  I wasnít noticing any effects, but the last few days I have been having very vivid dreams throughout the night. They leave me feeling a little disoriented in the morning.  During the day I have been a bit out of it and sleepy and if I close my eyes and doze,  I  start dreaming right away.

I know there are some reports of this with rilpivirine.   Has anyone experienced something similar? Did it go away after some time? Does it seem likely to be related if it didnít start for three weeks since I started taking Juluca?
~~~~
[month/date/year]
3/1/16: Tested neg (Oral swab)
6/17/16: Diagnosed poz (finger prick), confirmed w/Multispot assay
6/17/16: VL 22,900, CD4 - 524 cells/uL (30%)
7/2/16: Started Triumeq (DTG+ABC+3TC)
8/1/16: VL 30
10/4/16: VL <20, CD4 - 630 (31%)
1/4/17: VL 90
2/7/17: Undetected
4/17/17: Undetected, CD4 - 695 (33%)
7/20/17: VL 75
8/21/17: VL <20
11/27/17: VL<20
3/26/18: VL<20, CD4 - 701 (36%)
5/14/18: Switch to Juluca (DTG+RPV)
6/11/18: VL<20
7/25/18: Undetected, CD4 - 632 (38%)

Offline awakening

  • Member
  • Posts: 146
Re: Anyone taking Juluca?
« Reply #8 on: June 14, 2018, 02:57:51 pm »
Just finished my first month on Juluca (DTG+RPV). The mental fog and intense sleep/dreams I described previously seemed to pass after a visit to my acupuncturist. Whether that made the difference or not is unknown, but nevertheless it cleared. I just got my VL checked and am still UD  ;D. Doctor says other labs were normal.

I do find the food requirement is taking a bit of getting used to compared with Triumeq. Fact is I almost always took Triumeq with food as it made it easier for me to take, but I wasn't thinking about the amount of calories or whether it was enough food. They say absorption of rilpivirine is reduced 50% when taken fasting. But there are so many variables such as body weight, etc. that affect the strength of our meds. I am not counting calories, but try to make sure I'm eating more than just a banana. But maybe that would work too. I don't know if they actually have researched the calorie requirements of RPV when combined with DTG, they seem to be using historical data on RPV when it comes to the food requirement.

Over the last week I seem to have developed a bit of erecticle disfunction which is a bit concerning as its new for me. Surely my sex drive has decreased gradually over the years, but erections are really difficult to get and maintain this week. I don't see any info on-line associating my meds with ED but it does seem to be common with PLHIV, so not sure where that comes from. I will monitor and return to my doc if it continues.
~~~~
[month/date/year]
3/1/16: Tested neg (Oral swab)
6/17/16: Diagnosed poz (finger prick), confirmed w/Multispot assay
6/17/16: VL 22,900, CD4 - 524 cells/uL (30%)
7/2/16: Started Triumeq (DTG+ABC+3TC)
8/1/16: VL 30
10/4/16: VL <20, CD4 - 630 (31%)
1/4/17: VL 90
2/7/17: Undetected
4/17/17: Undetected, CD4 - 695 (33%)
7/20/17: VL 75
8/21/17: VL <20
11/27/17: VL<20
3/26/18: VL<20, CD4 - 701 (36%)
5/14/18: Switch to Juluca (DTG+RPV)
6/11/18: VL<20
7/25/18: Undetected, CD4 - 632 (38%)

Offline welive

  • Member
  • Posts: 10
Re: Anyone taking Juluca?
« Reply #9 on: June 15, 2018, 08:52:00 am »
I have also been on Juluca for 6 weeks now and I'm undectiable as of June 13th, 2018. The awesome thing is i was dectiable prior to starting Juluca because i took a cocktail break after trying different meditations. I have mixed feelings with Juluca, it causes me servere insomina. and I've also noticed erticle dysfunction since I've started Juluca. My family feel to believe that I'm in a better mental space since I've started Juluca so I'm trying to hang in there before i think about switching to something else again, maybe the side effects will lessen soon. I wish you well also.

Online JimDublin

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  • Posts: 10,164
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Re: Anyone taking Juluca?
« Reply #10 on: June 15, 2018, 10:44:57 am »
Why did switch to Juluca?

I say that as you seemed to have issues with DTG and have now switched from TRUIMEG to Juluca, thus keeping DTG.
HIV 101 - Everything you need to know
HIV 101
Transmission and Risks:
HIV Transmission and Risks
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline etaoinshrdlu

  • Member
  • Posts: 16
Re: Anyone taking Juluca?
« Reply #11 on: August 13, 2018, 07:45:21 pm »
Just ordered my first prescription of Juluca today, will arrive tomorrow. Switching from Triumeq. Wasn't having any problems on that. I'm attracted to the idea it's only two drugs (yeah, Viiv's marketing influenced me, I suppose) and is NRTI-sparing. And, interestingly, of all the STRs now available, it's the cheapest in my insurance company's formulary. A 90-day supply is $700 less than Triumeq. Cigna should be happy!

Offline awakening

  • Member
  • Posts: 146
Re: Anyone taking Juluca?
« Reply #12 on: August 15, 2018, 12:16:25 am »
Iíve been on Juluca 3 months now and doing well. There were some weird moments in the first month but I feel settled now. No adverse effects. Switched the time of day I take it a bit to meet the food requirement. I donít count calories, just eat some food. Iíve maintained UD and my CD4 %  continues to rise. Itís in the normal range now 😊
~~~~
[month/date/year]
3/1/16: Tested neg (Oral swab)
6/17/16: Diagnosed poz (finger prick), confirmed w/Multispot assay
6/17/16: VL 22,900, CD4 - 524 cells/uL (30%)
7/2/16: Started Triumeq (DTG+ABC+3TC)
8/1/16: VL 30
10/4/16: VL <20, CD4 - 630 (31%)
1/4/17: VL 90
2/7/17: Undetected
4/17/17: Undetected, CD4 - 695 (33%)
7/20/17: VL 75
8/21/17: VL <20
11/27/17: VL<20
3/26/18: VL<20, CD4 - 701 (36%)
5/14/18: Switch to Juluca (DTG+RPV)
6/11/18: VL<20
7/25/18: Undetected, CD4 - 632 (38%)

Offline etaoinshrdlu

  • Member
  • Posts: 16
Re: Anyone taking Juluca?
« Reply #13 on: August 17, 2018, 12:00:35 am »
My Juluca arrived yesterday, a day late. Sometimes I think the UPS delivery person just skips my house. I was home all day; no doorbell ring, just an email at 16:03 informing me no one was home! Grr. Anyway...

Can't say I've noticed anything different after two days of dosing. Forming the habit of taking it with a meal rather than right before bed will likely be my only challenge.

It's amazing this tiny little pill can keep us alive.

Offline xunil

  • Member
  • Posts: 97
Re: Anyone taking Juluca?
« Reply #14 on: September 11, 2018, 06:03:22 pm »
Iíve been on Juluca 3 months now and doing well. There were some weird moments in the first month but I feel settled now. No adverse effects. Switched the time of day I take it a bit to meet the food requirement. I donít count calories, just eat some food. Iíve maintained UD and my CD4 %  continues to rise. Itís in the normal range now 😊

So the ED went away?  That's the only thing I've seen mentioned about Juluca that have me slightly concerned. lol 

I received my first prescription of it today.  I've been on Triumeq since I was diagnosed about 4 years ago.  I have been complaining about general tiredness that I feel like was there before I started treatment (started post-infection but pre-diagnosis), but my doc recommended giving things a little switch up and see what happens.  I had the choice between Biktarvy and Juluca.  I talked to my pharmacist about both options, who works in the same building as my doctor and very closely with their team.  I think it makes the most sense for me to try something that includes the same integrase inhibitor I've been on and drops two drugs and adds one new one.

If nothing changes he said I can switch to Biktarvy and see if it is the dolutegravir that may be causing me a little trouble.  Overall he seems to think the dual therapy and these two drugs in particular are superior in terms of less side effects and less negative impact on overall health (that we know about so far).  He seems to think a lot of the complications that get blamed on dolutegravir are due to people taking Triumeq and it's really the abacavir that is causing people a lot of trouble.  We'll see if it makes any difference for me.
Diagnosed April 2015
First labs and specialist visit April 2015
Initial appt and labs: CD4 560 and VL 18,000
Started Triumeq June 2015
VL UD after 30 days on Triumeq, CD4 slowly rising.

 


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