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Author Topic: New way found to defeat HIV latency?  (Read 703 times)

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Offline Ptrk3

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New way found to defeat HIV latency?
« on: March 11, 2018, 01:38:18 pm »
Link to March 8, 2018, story from Science Daily (HIV and AIDS):

https://www.sciencedaily.com/releases/2018/03/180308143143.htm

Excerpt from article:

Researchers at UC Davis Health, together with colleagues at UC San Francisco and the University of North Carolina at Chapel Hill, have found that increased crotonylation, an epigenetic mechanism that governs gene expression, might be the key to making HIV come out of hiding and become susceptible to anti-HIV drugs. Their study is published in The Journal of Clinical Investigation.

"We have been working on mechanisms that could be used to disrupt HIV latency," said Satya Dandekar, chair of the UC Davis Department of Medical Microbiology and Immunology and senior author on the paper. "The goal is to force the virus to be expressed so it is visible to the immune system and can be targeted through immuno-therapeutics. This is the first study to identify histone crotonylation as a driver for HIV transcription and de-crotonylation of histone as an epigenetic marker for HIV silencing."
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