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Author Topic: Statins vs CD4. Any info on taking statins and effect on CD4?  (Read 2593 times)

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Offline randym431

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Statins vs CD4. Any info on taking statins and effect on CD4?
« on: December 04, 2006, 04:53:58 AM »
I donít know if anyone has any sure info on this. Seems I find both good and not so good reports on the effects of taking a statin (family of cholesterol lowering drugs), and cd4 counts in people on hiv meds.
Some reports claim the cd4's are knocked down as much as 47% when adding a statin, to fight high cholesterol. Other reports say there are no cd4 effects neg or pos. And then still other reports say not enough info is known to tell.
Since so many hiv folks on meds also find meds are bad news on the cholesterol counts, and many doctors throw in a statin to try to lower high cholesterol, I'm seeing it might also harm and hurt the cd4 recovery quite a bit. As one study suggested, as much as 47% cut in cd4 count after adding a statin, over weeks and months.

Does anyone have any better more reliable info or source of info on cd4 count and statins?

Offline J.R.E.

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  • Posts: 7,501
  • Joined Dec-2003 Living positive, since 1985.
Re: Statins vs CD4. Any info on taking statins and effect on CD4?
« Reply #1 on: December 04, 2006, 06:55:27 AM »
Hello Randy,

I had heard mention of this before, but am not familiar with it, and current studies going on. However here are a couple articles :


This article goes back to July of 05 :


Perhaps the pros can respond, with more current news on this.


Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 25 mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg






Diagnosed positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 As of 9/16/16,  t-cells are at 501,   Viral load remains <40

Current % is at 12%

 65 years young.

Offline randym431

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Re: Statins vs CD4. Any info on taking statins and effect on CD4?
« Reply #2 on: December 04, 2006, 08:14:28 AM »
Hi and thanks Ray.
I'm seeing that too. Conflicting reports.
Hope someone has more current info, or study maybe???

Offline pozniceguy

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  • Niceguy Dallas
Re: Statins vs CD4. Any info on taking statins and effect on CD4?
« Reply #3 on: December 04, 2006, 06:33:02 PM »
I don't know of any definitive studies but I can relate my experience.....cd4 decreased nearly 50   from 398 to 350 right after I started Crestor....does this prove anything??? maybe not but so far haven't had any serious decrease in Cholesterol either...been more than 6 months.
remember the good times...honor the past but don't live there
Le stelle la notte sono grandie luminose, nel cuore profondo del Texas

Offline budndallastx

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Re: Statins vs CD4. Any info on taking statins and effect on CD4?
« Reply #4 on: December 05, 2006, 07:00:46 AM »
The only thing I have seen is that the meds sometimes cause the statins to be metabolized faster forcing an increase in the dosage.  Still new to the meds and awaiting my first bloodwork after starting on the meds.  I'll ask my Dr. when I see him next week.

Meds since: 11/20/2006
Sustiva / Truvada
12/08/2008 VL:<48 CD4 622 (38%)   
9/8/2008 VL:<48 CD4 573 (30%)
5/2008 VL:<48 CD4 464 (30%)
1/2008  VL: <50  CD4 425(28%)
9/2007   VL: <50  CD4 465 (27%)
6/2007   VL: <50   CD4 443 (26%)
3/2007  VL: <50   CD4 385 (25%)
12/2006 - VL: <50   CD4: 384 (25%)
11/2006 - VL:  22K  CD4: 208 (18%)

Offline petsu

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  • Married. She is NEG.
Re: Statins vs CD4. Any info on taking statins and effect on CD4?
« Reply #5 on: December 08, 2006, 11:49:42 PM »
I remember reading a while back that Statins were possibly beneficial to CD4... You are making me want to quit the Lipitor!
Viramune, Truvada, Lipitor once daily.

Offline randym431

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  • Posts: 1,131
Re: Statins vs CD4. Any info on taking statins and effect on CD4?
« Reply #6 on: December 09, 2006, 02:45:44 AM »
Yes the info and the study results fall all over the place.
I guess you have to take into account the truth and slant by the durg companies on these studies.
I'd bet hiv folks on meds are a rather large block of income for these durg companies pushing their
statins. So they would want to point to good studies and ignore the bad.


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