Welcome, Guest. Please login or register.
November 23, 2017, 11:31:34 PM

Login with username, password and session length

  • Total Members: 31872
  • Latest: Bwolv
  • Total Posts: 722737
  • Total Topics: 58739
  • Online Today: 333
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 2
Guests: 106
Total: 108


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Kaletra only  (Read 2894 times)

0 Members and 1 Guest are viewing this topic.

Offline suzieque

  • Member
  • Posts: 61
Kaletra only
« on: November 19, 2006, 08:35:13 AM »
Hi all,
     I wondered if anyone has had any experience or knowledge of using only Kaletra? My doctor mentioned that some of his patients have done this ( without his prior knowledge) with good results. I am going to see him tomorrow to change my meds again (dreaded lipoatrophy!!) and need to make a decision about what to take. I have had lipo on several drug combo's, am currently on Reyayaz ( ritonavir booster), epivir and tenofovir. I know, I know, it is supposed to be a good combo for not causing lipoatrophy but my doctor says since that he has seen it now with several people where tenofovir was the only possible cause. Any words of advice would be appreciated!! Thanks :)

Offline newt

  • Member
  • Posts: 3,896
  • the one and original newt
Re: Kaletra only
« Reply #1 on: November 19, 2006, 10:49:12 AM »
See these reports:

Lopinavir monotherapy: less potent than triple therapy with higher risk of resistance esp Simon Collins' comment at bottom of page

Resistance implications of monotherapy with lopinavir/r (Kaletra)

Resistance, this is your big concern here. 

Various studies show 60-80% of people maintaing undetectable viral load using Kaletra alone at 48 weeks.   These small-scale studies do not really have time to look at CNS drug penetration and sanctuary sites etc, which may be important in terms of developing resistance.  But viral load of less than 50 after a year using just Kaletra is interesting.  If this was a short-term effect, and resistance developed in sanctuary sites, you would expect to see some kind of viral rebound detectable in the blood by then.

Short version: The nukes are doing something, but for everyone?. No-one knows when it's okay to discard them for certain, or indeed if long-term PI monotherapy works, but it seems to work for the majority of people for at least a year.

Kaletra + 3TC or abacavir may be another (but, erm, completely untested) approach to a less-nuke combo.

- matt
"The object is to be a well patient, not a good patient"

Offline newt

  • Member
  • Posts: 3,896
  • the one and original newt
Re: Kaletra only
« Reply #2 on: November 19, 2006, 11:04:54 AM »
Having read your other post re: abacavir sensitibity, I reckon Kaletra + 3TC or FTC is a good discussion to have.  FTC seems better re: damage to cellular metabolism but is otherwise sister to 3TC.  It also has a loooooong half-life, so maybe a better option there (more consistent drug level at end of daily dose should reduce risk of M184V mutation, which is kinda big if the single nuke drug level falls too low). 

- matt
"The object is to be a well patient, not a good patient"

Offline suzieque

  • Member
  • Posts: 61
Re: Kaletra only
« Reply #3 on: November 19, 2006, 11:29:22 AM »
   Thanks again for your reply. Nice to know that someones listening! My doctor did mention Kaletra with just epivir...will let you know what he says tomorrow.


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.