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Author Topic: Study on gut mucasal T-cells in HIV-positive  (Read 1080 times)

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Offline TigerPoz

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  • Posts: 11
Study on gut mucasal T-cells in HIV-positive
« on: March 13, 2014, 07:12:57 AM »
Interesting study (and good news) about the impact of prolonged cART on gut mucosa integrity:


A little background:
Acute HIV-1infection leads to massive loss of mucosal CD4 T-cells, that persists into the chronic phase, and is inconsistently recovered upon antiretroviral therapy.
Loss of epithelial integrity and high levels of circulating microbial products have been reported even in treated patients, and are considered important contributors to HIVassociated pan-immune activation that underlies HIV/AIDS pathogenesis. The
heightened activation state of the immune system is also associated with increased
risk of non-infectious events in ART-treated individuals.

The authors conclude : Despite the reduced Th22 subset, innate IL-22-mediated mechanisms, essential for sigmoid mucosa integrity, were fully operational in long-term treated HIV-1-infected individuals. The sample size of 37 individuals  is however not that impressive.
Best regards,

2013-03-01: HIV Negative
2013-06-09:HIVRNA 540487 CD4+:320 CD8+:230
- started Atripla
2013-06-19:HIVRNA 118971 CD4+:640 CD8+:430
2013-07-10:HIVRNA    1175 CD4+:710 CD8+:480
2013-08-05:HIVRNA       31 CD4+:740 CD8+:400
2013-09-11:HIVRNA       98 CD4+:940 CD8+:930
2013-11-05:HIVRNA       UD CD4+:1000CD8+:1000 changed to Stribild
2013-12-04: HIVRNA      UD CD4+: 990 CD8+:880


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