Welcome, Guest. Please login or register.
January 24, 2018, 01:02:05 AM

Login with username, password and session length

  • Total Members: 32204
  • Latest: JUANILD
  • Total Posts: 725508
  • Total Topics: 59151
  • Online Today: 163
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 3
Guests: 120
Total: 123


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: (AmpB?) ICO Therapeutics: Could AmpB Provide A Functional Cure For HIV?  (Read 1656 times)

0 Members and 1 Guest are viewing this topic.

Offline JazJon

  • Member
  • Posts: 94
Saw this in my google auto-search "HIV CURE" related news email today.  I did a search on the forums and didn't see anything posted about it already.



A look at oral AmpB
As iCo Therapeutics Inc, (ICO) awaits all-important Phase II trial results in March/April 2014 on iCo-007 for diabetic macular edema (DME). We review its oral formulation of amphotericin B (AmpB). iCo recently started an in vitro study using samples from HIV patients undergoing highly active antiretroviral therapy (HAART), to assess if AmpB can lower latent viral loads, which could reduce the need for lifelong HAART in HIV/AIDS patients.

Developing oral amphotericin B
iCo is advancing an oral formulation of antifungal AmpB, a drug typically used intravenously for systemic fungal infections but associated with high toxicity. iCo anticipates that a successful oral formulation can reduce safety risks and broaden patient access to this antifungal. iCo is seeking funding for the necessary GLP/GMP preclinical work to enable Phase I testing.

Could AmpB provide a functional cure for HIV?
While HAART is the mainstay for treating HIV, it does not eradicate the virus as latent viral reservoirs form in certain immune cells, resulting in a need for lifelong therapy. Preclinical data suggest that AmpB could potentially reactivate latent HIV expressing cells while inhibiting HIV replication, which may allow the immune system to fully eradicate infected cells and possibly facilitate a “functional cure” for HIV. The “functional cure” represents a potentially disruptive holy grail in the $14bn global HIV drugs market, as other companies (eg Sangamo with SB-728) are also developing treatments seeking to lessen or eliminate the need for lifelong HAART.

In vitro AmpB study in HIV patients on HAART
iCo has started a study in which eight patients undergoing HAART (recruitment to complete in Q214) with detectable latent viral reservoirs will have their serum extracted, treated with AmpB and then evaluated in vitro to determine the effects on such reservoirs.

Valuation: C$35m EV discounts development risk
The AmpB opportunity could generate long-term value, but is at a very early stage in relation to iCo-007 for DME, the primary near-term value driver. iCo finished Q313 with C$2.1m in net cash. With a 9M13 burn rate of C$2.6m and a recent (November 2013) exercise of C$0.96m in warrants, we estimate net cash of C$2.3m as of end December 2013, and a funding runway into Q314. iCo’s EV of C$35m discounts the potential of iCo-007 in a DME market estimated at US$7bn, so positive Phase II (iDEAL study) data could generate significant upside.

Offline darryaz

  • Member
  • Posts: 450
Re: (AmpB?) ICO Therapeutics: Could AmpB Provide A Functional Cure For HIV?
« Reply #1 on: January 24, 2014, 06:47:19 PM »
I haven't read the articles yet.... I'll click the links shortly.

I've been through through 3 rounds of IV Amphotericin-B for fungal infections.

I have noticed that after each round I experience a CD-4 increase of roughly 200 points.  It usually only lasts about 6 months to a year though.  Then I'm back to my usual level.

Interesting idea, although any of us who have experienced Ampho-terrible will tell you that the side effects can be horrific.  Not sure which one I'd pick - going  through it again or sticking with HAART for the rest of my life.


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.