Welcome, Guest. Please login or register.
November 23, 2017, 09:31:15 PM

Login with username, password and session length

  • Total Posts: 722733
  • Total Topics: 58738
  • Online Today: 333
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 2
Guests: 135
Total: 137


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Genetically distinct HIV-1 variants in cerebrospinal fluid and plasma during ART  (Read 1492 times)

0 Members and 1 Guest are viewing this topic.

Offline oksikoko

  • Member
  • Posts: 690
  • Writing the congressman again
Do any of you have thoughts on this? From the Journal of Infectious Diseases:

“We sequenced HIV-1 in 70 CSF and 29 plasma samples and the corresponding pre-therapy samples from 17 subjects on suppressive therapy. More of the CSF sequences were hypermutants than plasma sequences. We generated on-therapy sequences from both CSF and plasma from two subjects; in one we found genetically distinct sequences in CSF and plasma indicating that they came from two different compartments, one potentially the CNS, during suppressive therapy. In addition, there was little evidence of viral evolution in the CSF during therapy, suggesting that continuous virus replication is not the major cause of viral persistence in the CNS.”

1) More of the CSF sequences were hypermutants. What do they mean by hypermutants? Quickly mutating strains? Strains that mutate a lot? Strains with ADHD?

2) They found genetically distinct sequences in the blood plasma and CSF. They also found evidence suggesting that viral replication is not the major cause of viral persistence in the CNS. So, are they suggesting that both of these locations (blood and CSF) are being 'seeded' by different reservoirs (therefore different sequences) and that viral replication isn't happening in the blood or the CSF due to ART? Or that due to ART they're now closed systems and only have whatever strains were there at the onset of ART since therapy is holding further mutations at bay?

3) Is it normal with viruses and pathogens in general for there to be different “strains” (I assume this is what's meant by different genetic sequences) predominating in different body systems? I suppose with any long-lived infection, different strains would mutate and find niches in our bodies.

4) Does this mean, in theory, they should be trying to target the CNS with different medications than the ones we use to bring plasma viral loads down?

I don't need the answers to any of these for any reason. Just curious if anyone had thoughts.


Code: [Select]
2014-11-14: CD4 Wars Episode II: Return of the Stribild (released in Europe as Stribild II: Werewolf Bitch)
2014-11-06:                ☣ VL (→) 12,627      ☣ CD4 (→) 639
2014-??-??: off treatment  ☣ VL (?)              ☣ CD4 (?)
2013-10-03:                ☣ VL (=) undetectable ☣ CD4 (+) 1105
2013-05-23:                ☣ VL (=) undetectable ☣ CD4 (-) 945
2013-02-25:                ☣ VL (-) undetectable ☣ CD4 (+) 1123
2012-12-16: Enter Stribild
2012-11-20: HIV+           ☣ VL (→) 132,683      ☣ CD4 (→) 920
2012-04-01: HIV-
Dates in this signature file conform to ISO 8601. ;-)

If no one complains, nothing will ever change.

Offline Tadeys

  • Member
  • Posts: 162
Strains with ADHD?..... ;D


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.