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Author Topic: could the integrase inhibitor be the end to resistance(or a big leap forward)?  (Read 3605 times)

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Offline paulG

  • Member
  • Posts: 5
ok guys,
so i'm sure everybody has heard about the integrase inhibitor,mainly the MK-0518 which is set to be launched in 2007 if the amazing results keep racking in :)
now there has been a lot of talks about how the resistance virus would be non-viable and very replication defective...
is anybody out there following the mutation issue of the integrase inhibitor ??
i hope that we will be finally be able to control the resistance problem faced by many....
Cheers , Paul

Offline MitchMiller

  • Member
  • Posts: 564
This is about the integrase inhibitor licensed by Gilead.  I'm posting the link because the article contains a table which is not readable when cut and pasted.


Offline paulG

  • Member
  • Posts: 5
ok let's get into more specifics my man mitchell,let's talk about the merck HIV integrase drug...it's been in clinical trial for almost a year and a half and no signs of resistance (or drug failure) were observed.
how do you explain that? if you google : RC of merck integrase inhibitor you will see its superior resistance profile, and how you need a specific sequence of at least 4 mutations to render this drug inefficient...knowing that the virus with those mutations will be extremely weak, and super sensitive to all the other drugs...

Offline blondbeauty

  • Member
  • Posts: 1,787
That would be great, Paul!  ;)
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline Christine

  • Member
  • Posts: 1,069
I have been really foggy this week...I am not understanding the study. Is it saying resistance happens easier with the GS-9137 or does the GS-9137 make is harder for resistance to happen?

Poz since '93. Currently on Procrit, Azithromax, Pentamidine, Valcyte, Levothyroxine, Zoloft, Epzicom, Prezista, Viread, Norvir, and GS-9137 study drug. As needed: Trazodone, Atavan, Diflucan, Zofran, Hydrocodone, Octreotide

5/30/07 t-cells 9; vl 275,000


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