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Author Topic: Dolutegravir approval  (Read 2641 times)

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Offline vertigo

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Dolutegravir approval
« on: August 13, 2013, 06:45:38 PM »
The FDA approved the new integrase inhibitor dolutegravir yesterday.  It will be marketed as Tivicay:


This drug is going to be big.  The first once-daily, unboosted integrase inhibitor.  Basically Isentress but only one time a day.  Dr Paul Sax has been pretty keen on it for a while:


I think we're going to hear a lot more about this, particularly once it gets formulated into single-tablet regimens.

Offline oksikoko

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Re: Dolutegravir approval
« Reply #1 on: August 13, 2013, 08:00:23 PM »
Someone please get me a job in the branding department of one of these companies. First "Stribild" now "Tivicay"? I want it, though, if it doesn't come with cobicistat.

Marketing aside, does anyone know where the real names come from? I see inTEGRAse and VIRus in there, but what's a "dolu", an "elvi" and a "ral"?

Lee, focusing on what's really important here since 1976
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2014-11-14: CD4 Wars Episode II: Return of the Stribild (released in Europe as Stribild II: Werewolf Bitch)
2014-11-06:                ☣ VL (→) 12,627      ☣ CD4 (→) 639
2014-??-??: off treatment  ☣ VL (?)              ☣ CD4 (?)
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2013-02-25:                ☣ VL (-) undetectable ☣ CD4 (+) 1123
2012-12-16: Enter Stribild
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Offline Ann

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Re: Dolutegravir approval
« Reply #2 on: August 14, 2013, 06:32:19 AM »

This drug is going to be big. 

I agree. My doctor (aka the Wizard of Poz - he's also an hiv pharmacologist with years of med research under his belt) has been really excited about this med, and he doesn't get excited very easily. :)
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Offline Matts

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Re: Dolutegravir approval
« Reply #3 on: August 14, 2013, 07:58:44 AM »
Prescribing and Dosage Information are available:

The side effects seem to be low. It can make problems with Hep B or C coinfections.

And "Coadministration of TIVICAY with dofetilide is contraindicated due to the potential for increased dofetilide plasma concentrations and the risk for serious and/or life-threatening events."
[see Drug Interactions (7)].
« Last Edit: August 14, 2013, 08:03:57 AM by Matts »


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