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Author Topic: Sangamo live web cast update on ZFP @ 3.50 ET today  (Read 2532 times)

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Offline Common_ground

  • Member
  • Posts: 292
Sangamo live web cast update on ZFP @ 3.50 ET today
« on: September 06, 2012, 01:11:56 PM »
Sangamo will today broadcast an update live on their ZFP HIV/AIDS therapy. Link on sangamo.com under investor relations.
2011 May - Neg.
2012 June CD4:205, 16% VL:2676 Start Truvada/Stocrin
2012 July  CD4:234, 18% VL:88
2012 Sep  CD4:238, 17% VL:UD
2013 Feb  CD4:257, 24% VL:UD -viramune/truvada
2013 May CD4:276, 26% VL:UD

2015 CD4: 240 , 28% VL:UD - Triumeq
2015 March CD4: 350 VL: UD

Offline Jmarksto

  • Member
  • Posts: 655
Re: Sangamo live web cast update on ZFP @ 3.50 ET today
« Reply #1 on: September 06, 2012, 06:50:01 PM »
Thanks for the heads up on this -- the presentation is available to stream on thier web site for a few weeks. 

The short story of the presentation is that they are releasing preliminary results from the SB-728 trial on Monday, September 10th at the ICAAC (conference in S.F.).  The preliminary data indicates that the process not only reduces viral load but also increases CD4 cells.

As always, this news needs to be taken with a grain of salt - but it may be another piece to the puzzle for the long run.

03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45% VL 25
02/25/14 CD4   792/37% VL UD
07/09/14 CD4 1004/39% VL UD
11/03/14 CD4   711/34% VL UD
03/13/15 CD4   833/36% VL UD
04/??/15 Truvada & Tivicay
06/01/15 CD4 1100/50% VL UD
10/16/15 CD4   826/43% VL UD

Offline geobee

  • Member
  • Posts: 351
Re: Sangamo live web cast update on ZFP @ 3.50 ET today
« Reply #2 on: September 06, 2012, 07:24:48 PM »
It's not clear to me what news they are releasing.  They have older trials where they found that one heterozygote went UD.  They have two new trials (heteros and cytoxan/increase uptake of CD4s).  I think they are only releasing more data from the older trials.  They said previously they'd be releasing data from the two newer trials in in the first half of 2013.

Also, increasing CD4s is great!  But it's not surprising since they pump a lot of your own cells back into you.  If VL can be brought down significantly, or to zero, well, that will be really big news.

Offline PerfectlyHuman

  • Member
  • Posts: 23
Re: Sangamo live web cast update on ZFP @ 3.50 ET today
« Reply #3 on: September 09, 2012, 07:35:23 PM »
Is this supposed to be an actual cure or just reduction of viral load without taking meds every day?


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