Welcome, Guest. Please login or register.
November 18, 2017, 05:13:40 PM

Login with username, password and session length

  • Total Posts: 722416
  • Total Topics: 58702
  • Online Today: 326
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Powerful HIV Inhibitor makes virus mutation 'nearly impossible'  (Read 3456 times)

0 Members and 1 Guest are viewing this topic.

Offline John2038

  • Member
  • Posts: 1,529
  • Happiness is a journey, not a destination.
    • HIV Research News (Twitter)
Powerful HIV Inhibitor makes virus mutation 'nearly impossible'
« on: November 03, 2011, 03:37:20 PM »
UC Merced professor designs powerful chemical inhibitor against HIV

In a significant step toward reducing the threat of HIV, UC Merced Professor Patricia LiWang has designed what may be the most effective chemical inhibitor against infection of the virus.

"We need a fairly wide arsenal of HIV drugs because the virus is always mutating," LiWang said. "Drugs become less effective as time goes on."

LiWang's inhibitor, a novel combination of two existing drugs, has a strength that ranges from several times better than existing inhibitors to several hundred times better, depending on the strain of HIV. The inhibitor works by blocking HIV from entering a person's cell at two different steps of viral entry. This so-called "entry inhibition" is at the forefront of new strategies for stopping the virus. Other existing inhibitors have different strategies, such as preventing HIV from carrying out activities like replicating or integrating into the human genome.

There are hundreds of different strains of HIV, LiWang said, and the virus mutates when it gets inside a person's body.

"However, since this drug is a combination of two inhibitors, it would be nearly impossible for a virus to mutate so it wouldn't get hit with either one of these drugs," she explained.


Offline vaguesbleues

  • Member
  • Posts: 96
Re: Powerful HIV Inhibitor makes virus mutation 'nearly impossible'
« Reply #1 on: November 03, 2011, 07:25:54 PM »
Given the high rate of mutation of the virus, I am somewhat skeptical of the claims that these two novel drugs would render HIV mutation impossible. 
03/10/2011 - Tested HIV negative
04/26/2011 - Inconclusive WB result
05/19/2011 - Confirmed HIV positive
                     VL < 50, T-Cell 747 (30%)
06/13/2011 - VL 345, T-Cell 841 (30%)
08/23/2011 - VL 50,100, T-Cell 1155 (19%) - CMV
09/18/2011 - Started Atripla
11/07/2011 - VL 489, T-Cell 881 (31%)
02/08/2012 - VL Undetectable!, T-Cell 772 (34%)
08/08/2012 - VL UD, T-Cell 1070 (42%)
11/05/2012 - VL UD, T-Cell 1174 (35%)
03/18/2013 - VL UD, T-Cell 972 (28%)
10/04/2013 - VL UD, T-Cell 1025 (34%)
02/09/2014 - VL UD
07/31/2014 - VL UD
01/29/2015 - VL UD, T-Cell 1027 (32%)
09/15/2015 - VL UD
10/21/2016 - VL UD, T-cell 765 (39%)

Offline Coolio_7

  • Member
  • Posts: 66
Re: Powerful HIV Inhibitor makes virus mutation 'nearly impossible'
« Reply #2 on: November 03, 2011, 10:31:36 PM »
^^ I concur...unless these drugs kill off all the virus before it can mutate. But that doesn't even sound logical when there are reservoirs that current potent HAART cannot seem to eliminate.

We need to hear more about what this drug/s actually do.

Offline vaboi

  • Member
  • Posts: 40
    • Send Secure Email
Re: Powerful HIV Inhibitor makes virus mutation 'nearly impossible'
« Reply #3 on: November 06, 2011, 05:00:09 AM »
From reading the article, it sounds like this is a single protein that works in two different ways to block HIV replication.  Instead of needing multiple classes of drugs to block the virus in different ways at the same time to prevent mutation, this protein does it all with only a single drug.  The reason why this is so advantageous and resistant to mutation is because since there is only one drug, it'll always be consistent in any one place in the body, i.e. there will no longer be the effect of one drug's half-life being shorter than another thereby increasing the odds of one part of the body not having enough of one class of drug to prevent mutation.  This single drug will either be present fighting the virus on two different fronts at the same time at the same rate or not fighting it at all.. hence mutation against it is almost impossible. 


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.