Welcome, Guest. Please login or register.
October 21, 2017, 03:45:53 AM

Login with username, password and session length

  • Total Members: 31667
  • Latest: Kaz86
  • Total Posts: 721012
  • Total Topics: 58485
  • Online Today: 297
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 1
Guests: 263
Total: 264


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Hep B - Intradermal Vaaccination  (Read 2374 times)

0 Members and 1 Guest are viewing this topic.

Offline Growler

  • Member
  • Posts: 568
Hep B - Intradermal Vaaccination
« on: October 18, 2011, 11:42:39 PM »
Over the last 23 years I've been immunized (full course of 3 shots each time) against Hep B on 3 separate occasions....the last in 2009 finally took (antibody level 23mlU/ml).

During my most recent checkup the Hep B antibody level was measured and the result was 1mlU/ml, meaning no immunity  :(

I appreciate that Hep B vaccination in poz people can be less likely to take, but a little research has brought up the idea of Hep B intradermal vaccination. I'm wondering if anyone has come across any research on the success or otherwise of intradermal vaccination in poz people who have failed the intramuscular route?

« Last Edit: October 18, 2011, 11:52:35 PM by Growler »
“If loving someone is putting them in a straitjacket and kicking them down a flight of stairs, then yes, I have loved a few people.”

Offline tednlou2

  • Member
  • Posts: 5,731
Re: Hep B - Intradermal Vaaccination
« Reply #1 on: October 19, 2011, 12:06:20 AM »
I'm on my 2nd vaccination series.  The first, I got the Twinrix with the A and B.  They messed up the schedule giving me the first shot again a second time, when I was suppose to get the 2nd shot in the series.  So, that may have caused an issue.  I developed antibodies to A, but not B.

This time, they are doing an experiment by giving people a 4th shot instead of the normal 3 to see if that helps to create immunity.  We will see.  They did tell me that a few docs and nurses there who are HIV Neg cannot create immunity either.  On a side note, I've been hearing on the news how people over 65 should get the "higher-powered" flu vaccine, as they have a hard time creating a response sometimes as well.  I wondered why don't they just give that to everyone.  I didn't know there was a more powerful flu vaccine.  And, it got me thinking whether there are studies showing HIV poz folks should get higher doses of vaccines as well and whether that would be safe, etc, etc.   

Anyway, I'll be interested to hear any info others have to your main question.

Offline Growler

  • Member
  • Posts: 568
Re: Hep B - Intradermal Vaaccination
« Reply #2 on: October 22, 2011, 06:18:57 PM »
Thanks for the response and my sympathies about having to through a second round of shots...those buggers  bloody  sting!

On Friday i received a surprise call from an immunologist who consults for the HIV clinic I attend. While I had his ear I asked about the hep B vaccination situation and his reply was as follows.....if you've previously achieved a protective antibody level after undergoing the full course of the Hep B vaccinations then you will remain protected into the future. Antidody levels drop over time but the background level that remains is adequate  to respond in  the event of infection.

“If loving someone is putting them in a straitjacket and kicking them down a flight of stairs, then yes, I have loved a few people.”

Offline elf

  • Member
  • Posts: 634
Re: Hep B - Intradermal Vaaccination
« Reply #3 on: October 23, 2011, 05:42:15 AM »
Hi Growler.
We've talked about hepB here, maybe you find it useful:


My hepB response was low 6 months after the vaccination (3rd shot),
but 1 year later, antibodies appeared. : 550 of them, and apparently everything over 200 is ''good response''; <10 is not protective).

Brazilian immunologists found an effective scheme for HIVpositive people:
4 double doses of vaccine (4x2) taken at  0, 1, 2 and 6 months:

I think the best for you would be just one single double-dose shot.  :)
Full re-vaccination is needed only for those who have never achieved >10 mlU/ml.
« Last Edit: October 23, 2011, 05:55:46 AM by elf »
Getting used to my breakfasts with a pill of Complera.

Offline surf18

  • Member
  • Posts: 532
Re: Hep B - Intradermal Vaaccination
« Reply #4 on: October 23, 2011, 07:40:38 PM »
if you already had hep b are you immune from it forever?thanks

Offline Growler

  • Member
  • Posts: 568
Re: Hep B - Intradermal Vaaccination
« Reply #5 on: October 25, 2011, 02:52:48 PM »
Thanks elf for the info.....I agree, definitely worth checking out that booster shot.

I checked out the advice of the immunologist and generally his advice is correct according to the CDC


"How long does protection from Hepatitis B vaccine last?

Studies indicate that immunologic memory remains intact for at least 20 years among healthy vaccinated individuals who initiated Hepatitis B vaccination >6 months of age. The vaccine confers long-term protection against clinical illness and chronic Hepatitis B virus infection. Cellular immunity appears to persist even though antibody levels might become low or decline below detectable levels."

But as you suggest the situation for HIV infected individuals isn't so clear

"For other immunocompromised persons (e.g., HIV-infected persons, hematopoietic stem-cell transplant recipients, and persons receiving chemotherapy), the need for booster doses has not been determined. When anti-HBs levels decline to <10 mIU/mL, annual anti-HBs testing and booster doses should be considered for those with an ongoing risk for exposure. "

As surf18's question concerning life-long immunity after hep b infection


quote"If I had Hepatitis B in the past, can I get it again?

No, once you recover from Hepatitis B, you develop antibodies that protect you from the virus for life. An antibody is a substance found in the blood that the body produces in response to a virus. Antibodies protect the body from disease by attaching to the virus and destroying it. However, some people, especially those infected during early childhood, remain infected for life because they never clear the virus from their bodies."

That said having HIV may change this situation so it might be worth checking with your HIV specialist.

“If loving someone is putting them in a straitjacket and kicking them down a flight of stairs, then yes, I have loved a few people.”


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.