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Author Topic: Misc news  (Read 1433 times)

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Offline John2038

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Misc news
« on: October 18, 2011, 04:23:08 PM »
Few aidsmap news   ;)

Dolutegravir is potent but twice-daily works better
The novel integrase inhibitor dolutegravir is among the most potent antiretroviral agents studied to date, but treatment-experienced individuals need to take it twice-daily in order to achieve optimal concentrations, according to findings presented yesterday at the 13th European AIDS Conference (EACS) in Belgrade.

Overweight patients have best gains in CD4 cell count twelve months after starting HIV therapy
Patients who would normally be classified as overweight have the biggest increases in their CD4 cell counts during the first year of HIV therapy, US investigators report in the online edition of Clinical Infectious Diseases. Immune restoration after twelve months of antiretroviral therapy was greatest among individuals with a baseline body mass index (BMI) in the range 25 to 29.9 kg/m2, which is usually described as overweight.

Detectable viral load in patients taking HIV therapy associated with poor control of other chronic health problems
Poor control of HIV is associated with suboptimal management of other serious health conditions, US research published in the online edition of the Journal of Acquired Immune Deficiency Syndromes suggests.

Older age and immune response to CMV affect CD4 cell recovery after starting HIV therapy
Older age and a strong immune response to CMV infection adversely affect CD4 cell count recovery in patients taking antiretroviral therapy, French investigators report in the September 24th edition of AIDS.

New European HIV treatment guidelines expand treatment recommendations but anticipate possible drug shortages
The guidelines make no fundamental changes to the CD4 count criteria for starting antiretroviral therapy (ART), retaining 350 cells/mm3 as the threshold. But they extend the range of situations in which ART is recommended for people with higher CD4 cell counts and also include a range of situations in which ART should be 'considered'.

Efavirenz may be under-dosed in children
In a cohort of three to 12 year-old HIV-infected Ugandan children taking once-daily efavirenz according to 2006 World Health Organization (WHO) weight-band dosing recommendations, lower and highly variable amounts of drug entered their bloodstream compared to adults, investigators from the AntiRetroviral Research fOr Watoto (ARROW) trial team report in the advance online edition of the Journal of Acquired Immune Deficiency Syndromes.


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