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Author Topic: HTB supplement: 2011 pipeline report for HIV, HCV and TB  (Read 2570 times)

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Offline newt

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HTB supplement: 2011 pipeline report for HIV, HCV and TB
« on: July 13, 2011, 12:32:25 PM »
HIV, hepatitis C virus (HCV), and tuberculosis drugs, diagnostics, vaccines, and preventive technologies in development

writers from the Treatment Action Group (TAG), New York and HIV i-Base, London with contribution from Jonathan Berger of Section 27, South Africa on patents, IP and treatment access.


Selected highlights from the executive summary:

"As this i-Base and TAG 2011 Pipeline Report makes clear, medically, the prospect for people with HIV, hepatitis C virus (HCV), and tuberculosis (TB) to live long and healthy lives and in the cases of HCV and TB, to be cured rapidly with safe, effective, oral combination therapy have never been better."

"Politically and economically, the world's activists and political leaders face a crisis in which the former must persuade the latter to redirect billions of dollars from unproductive wars into life-saving health research and access programmes, at home and internationally."

"As the writers of this report reveal, the prospects for dramatic indeed in some cases revolutionary changes in prevention and treatment for the three diseases in the next decade are amazingly good. Decades of high-quality research, increased investment, and growing and targeted community-based activism have set the scene for the possibility for the first time since HIV/AIDS emerged in 1981 to make dramatic reductions in new HIV infections worldwide, while saving the lives of as many of the 34 million currently infected who can access therapy. Treatment is continually improving, with modern combinations dramatically less toxic, more tolerable, and easier to take than the first-generation ART combinations of the 1990s."

"Contrary to the predictions of obstinate pessimists who constantly bemoan the imminent emptying of the ARV pipeline [...] the 2011 HIV treatment pipeline is robust indeed, with twelve agents and fixed-dose combinations (FDCs) in phases II or III, still more in phase I, and two new drugs or formulations already approved in the last year the NNRTIs rilpivirine (Edurant) from Tibotec/J&J (although when this will be preferred in treatment-naive patients is unclear), and Boehringer Ingelheim's extended-release formulation of nevirapine, Viramune XR (just in time for the patent expiry on the original). Two new integrase inhibitors elvitegravir and dolutegravir are in late stages of development, both formulated in novel FDCs. This year's pipeline is at least as full as that of any year documented by TAG in our annual ARV pipelines since 2003."

- matt
"The object is to be a well patient, not a good patient"


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