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Author Topic: Supervirus?  (Read 1967 times)

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Offline Betelgeuse

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  • Posts: 163
« on: May 29, 2011, 04:49:27 AM »
Sounds like a super hero. . .   ???

Sorry for the newb question again.

When someone is said to have a "supervirus", does it mean he/she missed a couple of doses of their medication and that the virus mutated into an untreatable strain. . .  or

If you are HIV positive with a particular strain, and for whatever reason another strain is introduced into your system.  Do these two strains form an alliance to make up a super virus?

In reality, how common is this?  How dangerous is this?
04/19/11 - Diagnosed positive
04/29/11 - CD4 188 @ 12.5% / VL 18k
05/03/11 - CD4 171 @ unk% / VL 7k
06/04/11 - Start Truvada/Isentress
07/11/11 - CD4 not tested / VL UD
09/07/11 - CD4 252 @ unk% / VL UD

Offline mikeyb39

  • Member
  • Posts: 980
Re: Supervirus?
« Reply #1 on: May 29, 2011, 10:06:26 AM »
I think the 'supervirus' thing is still open for debate with the scientific community.  I know guys that take multi loads all the time and they still remain undetectable. I'm more worried about other types of bugs more than anything else at this point.

pardon my french above, hopefully didn't offend with my dirty talk...lol

11/02/2010  cd4-251, vl-591000
12/09/2010  started Atripla
02/18/2011  cd4-425, vl-800
06/10/2011  cd4-447, vl-70
10/10/2011  cd4-666, vl-80
01/05/2012  swiched med (prezista,norvir ,isentress, )
02/10/2012  cd4-733, vl-UD  Viread removed
06/10/2012  cd4-614, vl-UD
12/14/2012  cd4-764, vl-UD
09/01/2013  cd4-785, vl-UD
03/06/2014. cd4- 1078, VL-UD
09/05/2014  cd4-850 , VL-UD
09/05/2014 switched meds isentress, prezcobix -still only two antivirals
10/14/2015  cd4-600 , VL-UD

Offline Betelgeuse

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  • Posts: 163
Re: Supervirus?
« Reply #2 on: June 04, 2011, 11:28:24 PM »
I wanted to share a very kind response I received from Leatherman.  It explained everything so perfectly.


If someone continues to take meds but constantly stays under 95%, the HIV in their system can possibly mutate making one or all the meds in that regimen uneffective - that's called "resistance".  Resistance is not a guaranteed mutation.

Because some people have already had resistance issues, there are different mutations of HIV floating around that react differently to some meds. Theoritcally, if you are infected with one strain, you could be re-infected with another strain and end up with HIV with so much resistance that you will have a hard time finding a regimen to work. The virus is not "super" just resistance to multiple medications.

However, studies have shown that to become "super infected", a person would be infected by the second strain usually while they were not on treatment. If a person were being successfully treated (ie undetectable) IF they were to encounter another strain of HIV, their meds would destroy this new virus before it got a chance to get a foothold.

Hence, successfully treated people can technically have unprotected sex with other successfully treated people and run no risk of "super infection"; while there is only a theoritical risk if a successfully treated person was to have unsafe sex with a person with a high viral load. super infection really ONLY can happen when both people have high viral loads and is not guaranteed to happen.

Successfully treated people really have no reason at all to be concerned about resistance or super-infection.
04/19/11 - Diagnosed positive
04/29/11 - CD4 188 @ 12.5% / VL 18k
05/03/11 - CD4 171 @ unk% / VL 7k
06/04/11 - Start Truvada/Isentress
07/11/11 - CD4 not tested / VL UD
09/07/11 - CD4 252 @ unk% / VL UD

Offline Ann

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  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: Supervirus?
« Reply #3 on: June 05, 2011, 10:46:23 AM »
The super in superinfection or supervirus is not super as in super-dooper, it's super as in superimposed. One strain of virus on top of the other.
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Betelgeuse

  • Member
  • Posts: 163
Re: Supervirus?
« Reply #4 on: June 05, 2011, 01:39:00 PM »
I still think it's a good name for a superhero of the 21st century :)
04/19/11 - Diagnosed positive
04/29/11 - CD4 188 @ 12.5% / VL 18k
05/03/11 - CD4 171 @ unk% / VL 7k
06/04/11 - Start Truvada/Isentress
07/11/11 - CD4 not tested / VL UD
09/07/11 - CD4 252 @ unk% / VL UD


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