Welcome, Guest. Please login or register.
November 22, 2017, 11:01:18 PM

Login with username, password and session length

  • Total Posts: 722672
  • Total Topics: 58734
  • Online Today: 342
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 5
Guests: 255
Total: 260


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Prevalence and incidence of anal pre-cancerous lesions in men with HIV  (Read 1903 times)

0 Members and 1 Guest are viewing this topic.

Offline Miss Philicia

  • Member
  • Posts: 24,793
  • celebrity poster, faker & poser

High prevalence and incidence of anal pre-cancerous lesions in men with HIV; HAART has little impact

Published: 22 March 2011

Prevalence and incidence of high-grade pre-cancerous anal lesions in HIV-positive men who are taking antiretroviral therapy are high, Canadian investigators report in the online edition of Clinical Infectious Diseases.

A low nadir CD4 cell count and infection with HPV types 16 and 18 were associated with an increased risk of developing high-grade pre-cancerous anal lesions (AIN-2, 3).

The investigators hope that their findings will help identify patients who have a higher risk of HPV-associated anal disease.

Rates of HIV-related opportunistic infections have fallen significantly since the introduction of antiretroviral therapy.

However, the incidence of anal cancer is increasing.

Most of the information about the risk factors for this disease in HIV-positive gay men was obtained during the era before effective antiretroviral therapy became available. These include high-grade pre-cancerous lesions, infection with HPV 16 and 18, multiple HPV infections and CD4 cell count.

 Investigators from the Canadian Human Immunodeficiency and Papilloma Virus Research Group (HIPVIRG) wanted to establish a comprehensive understanding of the risk factors for progression to AIN 2 and 3. They also wished to see if treatment with anti-HIV drugs had any impact on disease progression.

A total of 247 men who were taking or about to initiate antiretroviral therapy were recruited to the study between 2002 and 2005.

The patients had swabs to see if they had anal HPV infection, and if present further tests were conducted to determine whether strains associated with anal cancer were present.

At baseline and then at intervals of six or twelve months the patients underwent high-resolution anoscopy to check for pre-cancerous lesions.

Median age at baseline was 43 years, 38% were smokers (a risk factor for HPV-related cancers), 90% were already receiving HIV therapy, median CD4 cell count was 380 cells/mm3 and 54% had an undetectable viral load.

On entry to the study, 19% of patient had normal anal cytology, 50% had low grade lesions, AIN 2 was present in 17%, and 13% had AIN 3.

Follow-up was for a median of 38 months. High-grade anal lesions were identified at least once in 54% of patients. However, only two patients developed anal cancer.

A total of 147 who did not have AIN 2 or 3 at follow-up were followed so that the investigators could calculate rates of progression and risk factors.

Incident high-grade lesions were diagnosed in 57 patients, and this provided a rate of 12.8 cases per 1000 months of follow-up. The cumulative incidence was 23% after two years and 37% after 36 months.

Analysis that included men whose first two anoscopy results negative for high grade lesions showed a progression rate of 7 cases per 1000 person months and an 24-month incidence of 21%.

Risk factors for the development of AIN 2 or 3 included older age (40-49 years, OR = 3.09; 95% CI, 1.12-8.52; over 50, OR = 4.78; 95% CI, 1.29-17.73); a nadir CD4 cell count below 50 cells/mm3 (OR = 14.40; 95% CI, 1.45-143.58); infection with HPV 16 or 18 (OR = 14.18; 95% CI, 3.51-57.32), and infection with HPV 16 and 18 (OR = 31.03; 95% CI, 5.68-169.60).

Current CD4 cell count was not associated with disease progression, and there was only very modest evidence that therapy with anti-HIV drugs had a protective effect. Incidence of AIN 2 and 3 was slightly reduced among patients who had been taking HIV treatment for four or more years.

“We…found that men who had received their current HAART regimen for a longer time had a lower risk…especially after adjusting for nadir CD4 cell counts. This suggests that, although one cannot fully recover from HIV-induced immune deficiency, HAART could have some beneficial effect in reducing the risk of AIN-2,3,” comment the authors.

They conclude, “our study confirms the high prevalence and incidence of AIN-2,3 among HIV-infected MSM.”

Patients with a low nadir CD4 cell count could, the investigators believe, especially benefit from screening for pre-cancerous lesions. In addition, “typing could also be useful as an adjunct to cytological examination in primary screening.”

The author of the accompanying editorial believes the study “may being us closer to the identification of biological markers of AIN progression and provide a practical screen tool for anal HPV disease.


 de Pokomandy A et al. HAART and progression to high-grade anal intraepithelial neoplasia in men who have sex with men and are infected with HIV. Clin Infect Dis, online edition, doi: 10.1093/cid/cir064, 2011 (click here for the free abstract).

Severini A et al. Anal intraepithelial neoplasia in men living with HIV in the era of highly active antiretroviral therapy. Clin Infect Dis, online edition, doi: 10.1093/cid/cir070, 2011 (click here for the full text [£]).
"I’ve slept with enough men to know that I’m not gay"

Offline alberche

  • Member
  • Posts: 221
  • a distancia del mundo incierto, saludo mi suerte
I have had a rectal tissue sample analysis last year, and some altered cells were found; next week I will have the next check. It is a good idea to get an anal tissue test done once a year, just ast Papa Nicolau test is being done in women since many years ago for cervix cancer.
love is blindness...  a wonderful song!


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.