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Author Topic: HLA-B5071 test  (Read 1351 times)

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Offline cwbyway102

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  • Posts: 30
HLA-B5071 test
« on: January 24, 2011, 06:58:24 PM »
After gradual rise of my ALT numbers and creatine on my labs my doc sent me for and ultrasound of my kidneys(came back squeaky clean) and gave me an HLA-B5071 test,which i'm guessing came back positive since my doctors office called and said they are sending me a lab slip to see if i can take a different medication.
 I've been on Truvada Reyataz and Norvir for a year now with great success and have had no problems with the medication til now.The only problem is the high ALT number.
 Being that this these medications are working for me its kinda scary to have to change medications,especially since my numbers are still on the low side.Anyone had any experience with this test while on Truvada?
« Last Edit: January 25, 2011, 08:03:33 PM by cwbyway102 »
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

Offline newt

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  • the one and original newt
Re: HLA-B5071 test
« Reply #1 on: January 25, 2011, 06:04:40 AM »

The HLA-B5071 test is to see if you can take abacavir. The test rules in an allergy (but does not completely rule it out). If it is positive you can't take abacavir. I am guessing you doc is looking at switching the Truvada for Epzicom (abacavir + 3TC).

For me, raised ALT alone, especially if less then 5 times more than the top of normal values, is proably not a good enough single reason to change off Truvada (specifically the tenofovir in Truvada), especially as it's not affecting your kidneys. But, read in conjunction with other tests, consistently raised ALT can indicate impaired bone metabolism, and this could be a good reason to swap the tenofovir, since tenofovir can affect this.

In any case, the most likely drug to be affecting your liver is the Norvir.

If your ALT is not super high, there is time to explore other options, for example a combo with no Norvir, or using less Norvir, in addition to a switch from Truvada to Epzicom.

- matt
"The object is to be a well patient, not a good patient"


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